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Journal of Neurology
Published in: Journal of Neurology 1/2015

01-01-2015 | Review

Impulse control disorders in Parkinson’s disease: an overview from neurobiology to treatment

Authors: Emke Maréchal, Benjamin Denoiseux, Ellen Thys, David Crosiers, Barbara Pickut, Patrick Cras

Published in: Journal of Neurology | Issue 1/2015

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Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative brain disorder and is characterized by motor symptoms such as tremor, bradykinesia, rigidity and postural instability. A majority of the patients also develop non-motor symptoms. Impulse control disorders (ICD) are behavioural changes that often fail to be detected in clinical practice. The prevalence of ICD in PD varies widely from 6.1 to 31.2 % and treatment with dopaminergic medication is considered to be the greatest risk factor. Management consists mainly of reducing dopaminergic medication. In our experience, ICD has a tremendous impact on the quality of life of the patients and their families and should therefore not be disregarded. Studies addressing the role of ICD in PD caregiver strain are imperative. We attempt to give a comprehensive overview of the literature on the complicated neurobiology of ICD and discuss risk factors, genetic susceptibility, screening modalities and management.
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Metadata
Title
Impulse control disorders in Parkinson’s disease: an overview from neurobiology to treatment
Authors
Emke Maréchal
Benjamin Denoiseux
Ellen Thys
David Crosiers
Barbara Pickut
Patrick Cras
Publication date
01-01-2015
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 1/2015
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-014-7361-4

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