Top

Published in:

01-03-2011 | Original Communication

T1rho (T_1ρ) MR imaging in Alzheimer’ disease and Parkinson’s disease with and without dementia

Authors: Mohammad Haris, Anup Singh, Kejia Cai, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Arijitt Borthakur

Published in: Journal of Neurology | Issue 3/2011

Abstract

In the current study, we aim to measure T1rho (T _1ρ) in the hippocampus in the brain of control, Alzheimer’s disease (AD), Parkinson’s disease (PD), and PD patients with dementia (PDD), and to determine efficacy of T _1ρ in differentiating these cohorts. With informed consent, 53 AD patients, 62 PD patients, 11 PDD patients, and 46 age-matched controls underwent a standardized clinical assessment including mini-mental state examination (MMSE) and brain T _1ρ MRI on a 1.5-T clinical-scanner. T_1ρ maps were generated by fitting each pixel’s intensity as a function of the spin-lock pulse duration. In control, AD, PD and PDD, mean ± SE T _1ρ values in the right hippocampus (RH) were 92.15 ± 2.00, 99.65 ± 1.98, 85.68 ± 1.87, 102.47 ± 4.66 ms while in the left hippocampus (LH) these values were 90.16 ± 1.82, 99.53 ± 1.91, 84.33 ± 2.03, 95.33 ± 4.64 ms. Significant difference for both RH and LH T _1ρ across the groups (p < 0.001) was observed. Both RH and LH T _1ρ were significantly increased in AD compared to control (p = 0.034, p = 0.001) and PD (p < 0.001, p < 0.001). In control, both RH and LH T _1ρ values were significantly increased compared to PD (p = 0.031, p = 0.027) while compared to PDD only the RH T _1ρ value was significantly decreased (p = 0.043). Both RH and LH T _1ρ values in PD were significantly lower than PDD (p = 0.004, p = 0.032). No significant correlation between the T _1ρ and age as well as between T _1ρ and MMSE scores was observed. The serial measurement of T_1ρ in both AD and PD may provide the nature of disease progression and may contribute to their early diagnosis.

Aronen HJ, Ramadan UA, Peltonen TK, Markkola AT, Tanttu JI, Jääskeläinen J, Häkkinen AM, Sepponen R (1999) 3D spin-lock imaging of human gliomas. Magn Reson Imaging 17:1001–1010PubMedCrossRef

Borthakur A, Wheaton AJ, Gougoutas AJ, Akella SV, Regatte RR, Charagundla SR, Reddy R (2004) In vivo measurement of T1rho dispersion in the human brain at 1.5 Tesla. J Magn Reson Imaging 19:403–409PubMedCrossRef

Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R (2006) In vivo measurement of plaque burden in a mouse model of Alzheimer’s disease. J Magn Reson Imaging 24:1011–1017PubMedCrossRef

Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R (2006) Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 19:781–821PubMedCrossRef

Borthakur A, Sochor M, Davatzikos C, Trojanowski JQ, Clark CM (2008) T1rho MRI of Alzheimer’s disease. Neuroimage 41:1199–1205PubMedCrossRef

Burton EJ, McKeith IG, Burn DJ, Williams ED, O’Brien JT (2004) Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls. Brain 127:791–800PubMedCrossRef

Davatzikos C, Fan Y, Wu X, Shen D, Resnick SM (2008) Detection of prodromal Alzheimer’s disease via pattern classification of magnetic resonance imaging. Neurobiol Aging 29:514–523PubMedCrossRef

Firbank MJ, Harrison RM, O’Brien JT (2002) A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson’s disease. Dement Geriatr Cogn Disord 14:64–76PubMedCrossRef

Gibb WRG, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 51:745–752PubMedCrossRef

10.

Haris M, McArdle E, Fenty M, Singh A, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A (2009) Early marker for Alzheimer’s disease: hippocampus T1rho estimation. J Magn Reson Imaging 29:1008–1012PubMedCrossRef

11.

Ito K, Nagano-Saito A, Kato T, Arahata Y, Nakamura A, Kawasumi Y, Hatano K, Abe Y, Yamada T, Kachi T, Brooks DJ (2002) Striatal and extrastriatal dysfunction in Parkinson’s disease with dementia: a 6-[18F]fluoro-l-dopa PET study. Brain 125:1358–1365PubMedCrossRef

12.

Johnson KA, Holman BL, Mueller SP, Rosen TJ, English R, Nagel JS, Growdon JH (1988) Single photon emission computed tomography in Alzheimer’s disease. Abnormal iofetamine I 123 uptake reflects dementia severity. Arch Neurol 45:392–396PubMed

13.

Laakso MP, Partanen K, Riekkinen P, Lehtovirta M, Helkala EL, Hallikainen M, Hanninen T, Vainio P, Soininen H (1996) Hippocampal volumes in Alzheimer’s disease, Parkinson’s disease with and without dementia, and in vascular dementia: an MRI study. Neurology 46:678–681PubMed

14.

Mäkelä HI, De Vita E, Gröhn OH, Kettunen MI, Kavec M, Lythgoe M, Garwood M, Ordidge R, Kauppinen RA (2004) B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo. Magn Reson Med 51:4–8PubMedCrossRef

15.

Matsui H, Udaka F, Miyoshi T, Hara N, Tamura A, Oda M, Kubori T, Nishinaka K, Kameyama M (2005) N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography study of Parkinson’s disease with dementia. Intern Med 44:1046–1050PubMedCrossRef

16.

Matsui H, Nishinaka K, Oda M, Niikawa H, Kubori T, Udaka F (2007) Dementia in Parkinson’s disease: diffusion tensor imaging. Acta Neurol Scand 116:177–181PubMedCrossRef

17.

McGeer PL, Kamo H, Harrop R, Li DK, Tuokko H, McGeer EG, Adam MJ, Ammann W, Beattie BL, Calne DB et al (1986) Positron emission tomography in patients with clinically diagnosed Alzheimer’s disease. CMAJ 134:597–607PubMed

18.

McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA et al (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113–1124PubMed

19.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of health and human services task force on Alzheimer’s Disease. Neurology 34:939–944PubMed

20.

Michaeli S, Liimatainen T, Rydeen CE, Kotz CM, Nixon JP, Hanson T, Tuite PJ (2010) T(1rho) and T(2rho) MRI in the evaluation of Parkinson’s disease. J Neurol (Epub ahead of print)

21.

Nussbaum RL, Ellis CE (2003) Alzheimer’s disease and Parkinson’s disease. N Engl J Med 348:1356–1364PubMedCrossRef

22.

O’Brien J, Barber B (2000) Neuroimaging in dementia and depression. Adv Psychiatr Treat 6:109–119CrossRef

23.

Padovani A, Costanzi C, Gilberti N, Borroni B (2006) Parkinson’s disease and dementia. Neurol Sci 1:S40–S43CrossRef

24.

Regatte RR, Akella SV, Wheaton AJ, Lech G, Borthakur A, Kneeland JB, Reddy R (2004) 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects. Acad Radiol 11:741–749PubMed

25.

Santyr GE (1994) MR imaging of the breast imaging and tissue characterization without intravenous contrast. Magn Reson Imaging Clin N Am 2:673–690PubMed

26.

Senjem ML, Gunter JL, Shiung MM, Petersen RC, Jack CR Jr (2005) Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease. Neuroimage 26:600–608PubMedCrossRef

27.

Stebbins GT, Murphy CM (2009) Diffusion tensor imaging in Alzheimer’s disease and mild cognitive impairment. Behav Neurol 21:39–49PubMed

28.

Summerfield C, Junqué C, Tolosa E, Salgado-Pineda P, Gómez-Ansón B, Martí MJ, Pastor P, Ramírez-Ruíz B, Mercader J (2005) Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study. Arch Neurol 62:281–285PubMedCrossRef

29.

Tam CW, Burton EJ, McKeith IG, Burn DJ, O’Brien JT (2005) Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology 64:861–865PubMed

30.

Vymazal J, Righini A, Brooks RA, Canesi M, Mariani C, Leonardi M, Pezzoli G (1999) T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 211:489–495PubMed

31.

Witschey WR, Borthakur A, Elliott MA, Fenty M, Sochor MA, Wang C, Reddy R (2008) T1rho-prepared balanced steady-state free precession for rapid 3D T1rho-weighted MRI. J Magn Reson Imaging 28:744–754PubMedCrossRef

Title: T1rho (T1ρ) MR imaging in Alzheimer’ disease and Parkinson’s disease with and without dementia
Authors: Mohammad Haris
Anup Singh
Kejia Cai
Christos Davatzikos
John Q. Trojanowski
Elias R. Melhem
Christopher M. Clark
Arijitt Borthakur
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 3/2011
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-010-5762-6

2024 ASCO Annual Meeting

Springer Medicine

T1rho (T_1ρ) MR imaging in Alzheimer’ disease and Parkinson’s disease with and without dementia

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2011

Management of respiratory symptoms in ALS

Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson’s disease

Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson’s disease? An analysis using the 13C-acetate breath test

Photomyogenic response in Niemann–Pick type C: a case report

Early atrophy of pallidum and accumbens nucleus in Huntington’s disease

Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients