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01-01-2011 | Original Communication

Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies

Authors: Mario Manto, Josep Dalmau, Adrien Didelot, Véronique Rogemond, Jérôme Honnorat

Published in: Journal of Neurology | Issue 1/2011

Abstract

A severe subacute encephalitis associated with auto-antibodies to the NMDA receptor (NMDA-R) has been reported in humans. These antibodies are directed to NR1/NR2 heteromers of the NMDA receptor. We studied the effects of patients’ cerebrospinal fluid (CSF) injected in rFr2 (the prefrontal area) on the afferent facilitation in a conditioning paradigm for corticomotor responses. The afferent facilitation was assessed in forelimbs and hindlimbs of rats, before and after application of trains of high-frequency stimulation (HFS) which are known to modulate the excitability of M1. Before HFS, patients’ CSF did not modify afferent facilitation. After HFS, the amplitudes of corticomotor responses before conditioning were significantly larger in forelimbs and hindlimbs. There was an increase of the afferent facilitation in forelimbs. The same effect was observed after injection of purified IgGs from patients’ sera. Our results highlight that IgGs of patients with NMDA-R antibodies induce a state of corticomotor hyperexcitability following application of HFS over the prefrontal area.

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Title: Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies
Authors: Mario Manto
Josep Dalmau
Adrien Didelot
Véronique Rogemond
Jérôme Honnorat
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 1/2011
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-010-5674-5

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Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies

Abstract

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Abstract

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