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Published in:

01-08-2006

Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging

Authors: Sanjay Kalra, Peter Tai, Angela Genge, Douglas L. Arnold

Published in: Journal of Neurology | Issue 8/2006

Abstract

Riluzole prolongs survival in amyotrophic lateral sclerosis. The temporal and spatial profile of its effect on the brain is unknown. We used proton magnetic resonance spectroscopic imaging to evaluate the neuronal response to 1 day of riluzole treatment in motor and non-motor regions of the brain. In 10 patients the N-acetylaspartate/total creatine (NAA/Cr) ratio increased in the precentral gyrus and supplementary motor area, but not in the post-central gyrus or parietal lobe. Improvement in cortical neuronal metabolic function in the motor cortex occurs early with riluzole treatment.

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Title: Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging
Authors: Sanjay Kalra
Peter Tai
Angela Genge
Douglas L. Arnold
Publication date: 01-08-2006
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 8/2006
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0162-7

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Springer Medicine

Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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