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01-09-2010 | Original Article

Sequence polymorphisms of mtDNA HV1, HV2, and HV3 regions in the Malay population of Peninsular Malaysia

Authors: Abd Rashid Nur Haslindawaty, Sundararajulu Panneerchelvam, Hisham Atan Edinur, Mohd Nor Norazmi, Zainuddin Zafarina

Published in: International Journal of Legal Medicine | Issue 5/2010

Abstract

The uniparentally inherited mitochondrial DNA (mtDNA) is in the limelight for the past two decades, in studies relating to demographic history of mankind and in forensic kinship testing. In this study, human mtDNA hypervariable segments 1, 2, and 3 (HV1, HV2, and HV3) were analyzed in 248 unrelated Malay individuals in Peninsular Malaysia. Combined analyses of HV1, HV2, and HV3 revealed a total of 180 mtDNA haplotypes with 149 unique haplotypes and 31 haplotypes occurring in more than one individual. The genetic diversity was estimated to be 99.47%, and the probability of any two individuals sharing the same mtDNA haplotype was 0.93%. The most frequent mtDNA haplotype (73, 146, 150, 195, 263, 315.1C, 16140, 16182C, 16183C, 16189, 16217, 16274, and 16335) was shared by 11 (4.44%) individuals. The nucleotide diversity and mean of pair-wise differences were found to be 0.036063 ± 0.020101 and 12.544022 ± 6.230486, respectively.

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Title: Sequence polymorphisms of mtDNA HV1, HV2, and HV3 regions in the Malay population of Peninsular Malaysia
Authors: Abd Rashid Nur Haslindawaty
Sundararajulu Panneerchelvam
Hisham Atan Edinur
Mohd Nor Norazmi
Zainuddin Zafarina
Publication date: 01-09-2010
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 5/2010
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-010-0469-x

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Sequence polymorphisms of mtDNA HV1, HV2, and HV3 regions in the Malay population of Peninsular Malaysia

Abstract

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