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European Archives of Psychiatry and Clinical Neuroscience

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01-03-2017 | Short Communication

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression

Authors: Yukihiko Shirayama, Kenji Hashimoto

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 2/2017

Abstract

Effects of a single bilateral infusion of R-enantiomer of ketamine in rat brain regions of learned helplessness model of depression were examined. A single bilateral infusion of R-ketamine into infralimbic (IL) portion of medial prefrontal cortex (mPFC), CA3 and dentate gyrus (DG) of the hippocampus showed antidepressant effects. By contrast, a single bilateral infusion of R-ketamine into prelimbic (PL) portion of mPFC, shell and core of nucleus accumbens, basolateral amygdala and central nucleus of the amygdala had no effect. This study suggests that IL of mPFC, CA3 and DG of hippocampus might be involved in the antidepressant actions of R-ketamine.

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Title: Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression
Authors: Yukihiko Shirayama
Kenji Hashimoto
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 2/2017
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-016-0718-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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