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European Archives of Psychiatry and Clinical Neuroscience

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01-03-2011 | Short Communication

Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder

Authors: Izabela Guimarães Barbosa, Rodrigo Barreto Huguet, Vanessa Amaral Mendonça, Lirlândia Pires Sousa, Fernando Silva Neves, Moisés Evandro Bauer, Antônio Lúcio Teixeira

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 2/2011

Abstract

Bipolar disorder (BD) has been associated with a proinflammatory state in which TNF-α seems to play a relevant role. The aim of the present study was to evaluate the plasma levels of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in BD patients in mania and euthymia in comparison with control subjects. We evaluated 53 BD patients (34 in mania and 19 in euthymia) and 38 healthy subjects. All subjects were assessed by the Mini-International Neuropsychiatry Interview (MINI-Plus). Patients were also evaluated by the Young Mania Rating Scale (YMRS) and by Hamilton Depression Rating Scale (HDRS). Plasma TNF-α and its soluble receptors were measured by ELISA. The plasma TNF-α and sTNFR2 levels did not differ between groups, but higher sTNFR1 levels were found in BD patients. Of note, BD patients in mania had higher sTNFR1 levels than BD patients in euthymia and controls. The sTNFR1 and sTNFR2 levels correlated with BD duration, and sTNFR2 levels correlated with age of patients. Our data indicate a proinflammatory status in BD patients during mania and further suggest that inflammatory mechanisms may be involved with the physiopathology of BD.

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Title: Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder
Authors: Izabela Guimarães Barbosa
Rodrigo Barreto Huguet
Vanessa Amaral Mendonça
Lirlândia Pires Sousa
Fernando Silva Neves
Moisés Evandro Bauer
Antônio Lúcio Teixeira
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 2/2011
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-010-0116-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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