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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 01-10-2010 | Letter to the editors

Is the word ‘biomarker’ being properly used by proteomics research in neuroscience?

Author: Daniel Martins-de-Souza

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 7/2010

Excerpt

Lately, when researchers see an article with the word “biomarker”, they feel, at least, suspicious. Sometimes, even scared and such feeling of distrust occurs mostly because the majority of the published articles in the field of global proteome analysis are revealing, for instance, differentially expressed proteins in pathologic conditions and claiming that biomarkers are being discovered. In addition to transform a differentially expressed protein in a biomarker, a long road has to be travelled. …

Chakravarty A (2003) Surrogate markers: their role in regulatory decision process. Food and Drug Administration, http://www.fda.gov/cder/Offices/Biostatistics/Chakravarty_376/sld016.htm

Mischak H, Apweiler R, Banks RE et al (2007) Clinical proteomics: a need to define the field and to begin to set adequate standards. Proteomics Clin Appl 1:148–156CrossRef

Title: Is the word ‘biomarker’ being properly used by proteomics research in neuroscience?
Author: Daniel Martins-de-Souza
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 7/2010
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-010-0105-2

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Is the word ‘biomarker’ being properly used by proteomics research in neuroscience?

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