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European Archives of Psychiatry and Clinical Neuroscience

Published in:

01-04-2009 | ORIGINAL PAPER

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

Authors: Daniel Martins-de-Souza, Wagner F. Gattaz, Andrea Schmitt, Christiane Rewerts, Giuseppina Maccarrone, Emmanuel Dias-Neto, Christoph W. Turck

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2009

Abstract

Schizophrenia is a complex disease, likely to be caused by a combination of serial alterations in a number of genes and environmental factors. The dorsolateral prefrontal cortex (Brodmann's Area 46) is involved in schizophrenia and executes high-level functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts and attitudes, correct social behavior and personality expression. Global proteomic analysis of post-mortem dorsolateral prefrontal cortex samples from schizophrenia patients and non-schizophrenic individuals was performed using stable isotope labeling and shotgun proteomics. The analysis resulted in the identification of 1,261 proteins, 84 of which showed statistically significant differential expression, reinforcing previous data supporting the involvement of the immune system, calcium homeostasis, cytoskeleton assembly, and energy metabolism in schizophrenia. In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease.

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Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia
Authors: Daniel Martins-de-Souza
Wagner F. Gattaz
Andrea Schmitt
Christiane Rewerts
Giuseppina Maccarrone
Emmanuel Dias-Neto
Christoph W. Turck
Publication date: 01-04-2009
Publisher: Steinkopff-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2009
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-008-0847-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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