Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 4/2024

03-02-2024 | Thyroid Cancer | Head and Neck

Assessment of quality of life in thyroid cancer patients using the EORTC thyroid-specific questionnaire: a prospective cross-sectional study

Authors: Shivakumar Thiagarajan, Khuzema Fatehi, Nandini Menon, Mahesh Sawant, Ankita Pal

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2024

Login to get access

Abstract

Background

Many studies on the quality of life (QoL) among the thyroid cancer survivors have shown conflicting results. This may be since many of these studies have not used thyroid cancer-specific questionnaires.

Patients and methods

In our study we have translated the EORTC THY-34, validated and served it in a cross-sectional study to the assess the QoL among thyroid cancer patients free of disease during their routine follow-up. Patients were categorized based on the duration from treatment completion, ATA risk stratification, treatment received, number of RAI sessions and thyroid function status during analysis.

Results

Overall, 220 thyroid cancer survivors were included in this study. In general, in the EORTC QLQ–C30, the global QoL of thyroid cancer patients were good with a mean score of 72.99. The highest score was that for social functioning (89.55). In the EORTC–THY34 all the patients in the cohort had relatively lower scores (on symptom scales). Overall, there was no difference in the QLQ–C30 and THY-34 QoL with respect to any of the categorization mentioned above. However, our thyroid cancer patients QoL scores were better and/or comparable to those in published literature and they were also better or comparable to the QoL of the general population those were available in literature.

Conclusions

There was no difference in the QoL scores based on various categories. To better understand the quality of life of these patients a prospective longitudinal study with baseline values and values at regular intervals might give us a better insight.
Appendix
Available only for authorised users
Literature
1.
go back to reference Vaccarella S, Franceschi S, Bray F et al (2016) Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med 375(7):614–617CrossRefPubMed Vaccarella S, Franceschi S, Bray F et al (2016) Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med 375(7):614–617CrossRefPubMed
2.
go back to reference Panato C, Vaccarella S, Dal Maso L et al (2020) Thyroid cancer incidence in India between 2006 and 2014 and impact of overdiagnosis. J Clin Endocrinol Metab 105(8):2507–2514CrossRefPubMedPubMedCentral Panato C, Vaccarella S, Dal Maso L et al (2020) Thyroid cancer incidence in India between 2006 and 2014 and impact of overdiagnosis. J Clin Endocrinol Metab 105(8):2507–2514CrossRefPubMedPubMedCentral
3.
go back to reference Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P (2022) Cancer incidence estimates for 2022 & projection for 2025: result from National Cancer Registry Programme, India. Indian J Med Res 156(45):598–607PubMed Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P (2022) Cancer incidence estimates for 2022 & projection for 2025: result from National Cancer Registry Programme, India. Indian J Med Res 156(45):598–607PubMed
4.
go back to reference Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T, Miya A (2018) Overall survival of papillary thyroid carcinoma patients: a single-institution long-term follow-up of 5897 patients. World J Surg 42(3):615–622CrossRefPubMedPubMedCentral Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T, Miya A (2018) Overall survival of papillary thyroid carcinoma patients: a single-institution long-term follow-up of 5897 patients. World J Surg 42(3):615–622CrossRefPubMedPubMedCentral
5.
go back to reference Pacini F, Catagana MG, Brilli L et al (2010) Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up. Ann Oncol 21(Suppl 5):v214–v219CrossRefPubMed Pacini F, Catagana MG, Brilli L et al (2010) Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up. Ann Oncol 21(Suppl 5):v214–v219CrossRefPubMed
6.
go back to reference Druz AK, Chaukar DA, Gupta T (2012) Guidelines for head and neck cancers. Tata Memorial Center, Mumbai Druz AK, Chaukar DA, Gupta T (2012) Guidelines for head and neck cancers. Tata Memorial Center, Mumbai
7.
go back to reference Edafe O, Wadsley J, Harrison BJ, Balasubramanian SP (2014) Treatment-related morbidity in differentiated thyroid cancer-a survey of clinicians. Thyroid Res 7(1):3CrossRefPubMedPubMedCentral Edafe O, Wadsley J, Harrison BJ, Balasubramanian SP (2014) Treatment-related morbidity in differentiated thyroid cancer-a survey of clinicians. Thyroid Res 7(1):3CrossRefPubMedPubMedCentral
8.
go back to reference Parker WA, Edafe O, Balasubramanian SP (2017) Long-term treatment-related morbidity in differentiated thyroid cancer: a systematic review of the literature. Pragmat Obs Res 16(8):57–67 Parker WA, Edafe O, Balasubramanian SP (2017) Long-term treatment-related morbidity in differentiated thyroid cancer: a systematic review of the literature. Pragmat Obs Res 16(8):57–67
9.
go back to reference Borget I, Corone C, Nocaudie M et al (2007) Sick leave for follow-up control in thyroid cancer patients: comparison between stimulation with Thyrogen and thyroid hormone withdrawal. Eur J Endocrinol 156(5):531–538CrossRefPubMed Borget I, Corone C, Nocaudie M et al (2007) Sick leave for follow-up control in thyroid cancer patients: comparison between stimulation with Thyrogen and thyroid hormone withdrawal. Eur J Endocrinol 156(5):531–538CrossRefPubMed
10.
go back to reference Dow KH, Ferrell BR, Anello C (1997) Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy. Thyroid 7(4):613–619CrossRefPubMed Dow KH, Ferrell BR, Anello C (1997) Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy. Thyroid 7(4):613–619CrossRefPubMed
11.
go back to reference Crevenna R, Zettinig G, Keilani M et al (2003) Quality of life in patients with non-metastatic differentiated thyroid cancer under thyroxine supplementation therapy. Support Care Cancer 11(9):597–603CrossRefPubMed Crevenna R, Zettinig G, Keilani M et al (2003) Quality of life in patients with non-metastatic differentiated thyroid cancer under thyroxine supplementation therapy. Support Care Cancer 11(9):597–603CrossRefPubMed
12.
go back to reference Schroeder PR, Haugen BR, Pacini F et al (2006) A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal. J Clin Endocrinol Metab 91(3):878–884CrossRefPubMed Schroeder PR, Haugen BR, Pacini F et al (2006) A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal. J Clin Endocrinol Metab 91(3):878–884CrossRefPubMed
13.
go back to reference Hoftijzer HC, Heemstra KA, Corssmit EP, van der Klaauw AA, Romijn JA, Smit JW (2008) Quality of life in cured patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 93(1):200–203CrossRefPubMed Hoftijzer HC, Heemstra KA, Corssmit EP, van der Klaauw AA, Romijn JA, Smit JW (2008) Quality of life in cured patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 93(1):200–203CrossRefPubMed
14.
go back to reference Lloyd S, Devesa-Martinez P, Howard DJ, Lund VJ (2003) Quality of life of patients undergoing surgical treatment of head and neck malignancy. Clin Otolaryngol Allied Sci 28(6):524–532CrossRefPubMed Lloyd S, Devesa-Martinez P, Howard DJ, Lund VJ (2003) Quality of life of patients undergoing surgical treatment of head and neck malignancy. Clin Otolaryngol Allied Sci 28(6):524–532CrossRefPubMed
15.
go back to reference Walshaw EG, Smith M, Kim D, Wadsley J, Kanatas A, Rogers SN (2022) A systematic review of health-related quality of life following thyroid cancer. Tumori 108(4):291–314CrossRefPubMed Walshaw EG, Smith M, Kim D, Wadsley J, Kanatas A, Rogers SN (2022) A systematic review of health-related quality of life following thyroid cancer. Tumori 108(4):291–314CrossRefPubMed
16.
go back to reference Husson O, Haak HR, Mols F, Nieuwenhuijzen GA, Nieuwlaat W-A, Reemst PH, Huysmans DA, Toorians AW, van de Poll-Franse LV (2013) Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors. Acta Oncol 52:447–454CrossRefPubMed Husson O, Haak HR, Mols F, Nieuwenhuijzen GA, Nieuwlaat W-A, Reemst PH, Huysmans DA, Toorians AW, van de Poll-Franse LV (2013) Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors. Acta Oncol 52:447–454CrossRefPubMed
17.
go back to reference Singer S, Jordan S, Locati LD, On behalf of the EORTC Quality of Life Group and the EORTC Endocrine Task Force the EH and NCG et al (2017) The EORTC module for quality of life in patients with thyroid cancer: phase III. Endocr Relat Cancer 24:197–207CrossRefPubMed Singer S, Jordan S, Locati LD, On behalf of the EORTC Quality of Life Group and the EORTC Endocrine Task Force the EH and NCG et al (2017) The EORTC module for quality of life in patients with thyroid cancer: phase III. Endocr Relat Cancer 24:197–207CrossRefPubMed
18.
go back to reference Kuliś D, Bottomley A, Velikova G, Greimel E, Koller M (2017) EORTC quality of life group translation procedure, 4th edn. EORTC Quality of Life Group Kuliś D, Bottomley A, Velikova G, Greimel E, Koller M (2017) EORTC quality of life group translation procedure, 4th edn. EORTC Quality of Life Group
19.
go back to reference Büttner M, Hinz A, Singer S, Musholt TJ (2020) Quality of life of patients more than 1 year after surgery for thyroid cancer. Hormones (Athens) 19(2):233–243CrossRefPubMed Büttner M, Hinz A, Singer S, Musholt TJ (2020) Quality of life of patients more than 1 year after surgery for thyroid cancer. Hormones (Athens) 19(2):233–243CrossRefPubMed
20.
go back to reference Lee JI, Kim SH, Tan AH et al (2010) Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea. Health Qual Life Outcomes 15(8):101CrossRef Lee JI, Kim SH, Tan AH et al (2010) Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea. Health Qual Life Outcomes 15(8):101CrossRef
21.
go back to reference Roberts KJ, Lepore SJ, Urken ML (2008) Quality of life after thyroid cancer: an assessment of patient needs and preferences for information and support. J Cancer Educ 23(3):186–191CrossRefPubMed Roberts KJ, Lepore SJ, Urken ML (2008) Quality of life after thyroid cancer: an assessment of patient needs and preferences for information and support. J Cancer Educ 23(3):186–191CrossRefPubMed
22.
go back to reference Gamper EM, Wintner LM, Rodrigues M et al (2015) Persistent quality of life impairments in differentiated thyroid cancer patients: results from a monitoring programme. Eur J Nucl Med Mol Imaging 42(8):1179–1188CrossRefPubMedPubMedCentral Gamper EM, Wintner LM, Rodrigues M et al (2015) Persistent quality of life impairments in differentiated thyroid cancer patients: results from a monitoring programme. Eur J Nucl Med Mol Imaging 42(8):1179–1188CrossRefPubMedPubMedCentral
23.
go back to reference Chen C, Cao J, Wang Y, Han X, Zhang Y, Zhuang S (2023) Health-related quality of life and thyroid cancer-specific symptoms in patients treated for differentiated thyroid cancer: a single-center cross-sectional survey from Mainland China. Thyroid 33(4):474–483CrossRefPubMed Chen C, Cao J, Wang Y, Han X, Zhang Y, Zhuang S (2023) Health-related quality of life and thyroid cancer-specific symptoms in patients treated for differentiated thyroid cancer: a single-center cross-sectional survey from Mainland China. Thyroid 33(4):474–483CrossRefPubMed
24.
go back to reference Singer S, Lincke T, Gamper E, Bhaskaran K, Schreiber S, Hinz A, Schulte T (2012) Quality of life in patients with thyroid cancer compared with the general population. Thyroid 22(2):117–124CrossRefPubMed Singer S, Lincke T, Gamper E, Bhaskaran K, Schreiber S, Hinz A, Schulte T (2012) Quality of life in patients with thyroid cancer compared with the general population. Thyroid 22(2):117–124CrossRefPubMed
Metadata
Title
Assessment of quality of life in thyroid cancer patients using the EORTC thyroid-specific questionnaire: a prospective cross-sectional study
Authors
Shivakumar Thiagarajan
Khuzema Fatehi
Nandini Menon
Mahesh Sawant
Ankita Pal
Publication date
03-02-2024
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 4/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-024-08471-w

Other articles of this Issue 4/2024

European Archives of Oto-Rhino-Laryngology 4/2024 Go to the issue