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European Archives of Oto-Rhino-Laryngology

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01-04-2021 | Autologous Fat | Laryngology

Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite

Authors: Karol Zeleník, Martin Formánek, Radana Walderová, Debora Formánková, Pavel Komínek

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2021

Abstract

Purpose

To evaluate 5-year voice outcomes of vocal fold augmentation (VFA) using autologous fat (AF) injection via direct microlaryngoscopy versus office-based calcium hydroxylapatite (CaHA) injection.

Methods

Retrospective study of patients who underwent VFA between 2012 and 2015, with a 5-year follow-up. Patients with a glottic gap of ≤ 3 mm caused by unilateral vocal fold paralysis or vocal fold atrophy were included in the study. VFA was performed using AF injection via direct microlaryngoscopy in 17 patients, and using office-based CaHA injection in 19 patients. Subjective satisfaction with voice, voice handicap index (VHI), and maximal phonation time (MPT) were analyzed pre-injection, and at 12 and 60 months post-VFA.

Results

Altogether 36 patients underwent VFA between 2012 and 2015, of whom 5 were excluded within 1 year post-VFA, and 2 were excluded between 1 and 5 years post-VFA. Of the remaining 29 patients, 3 (10.3%) underwent re-intervention at between 1 and 3 years post-VFA. Thus, the 5-year follow-up included 26 patients (72.2%; 11 males and 15 females). At 5 years after surgery, 73.1% of the patients were satisfied with their voice, with no significant between-group difference (P = 0.307). The mean improvement of VHI was 28.8 ± 17.82 in the autologous fat group versus 33 ± 26.24 in the CaHA group (P = 0.458). MPT improvement was also similar between the two groups: 6.2 ± 4.26 for the autologous fat group versus 6.3 ± 4.34 for the CaHA group (P = 0.667).

Conclusions

Both AF injection via direct microlaryngoscopy and office-based CaHA injection yielded good and comparable 5-year results.

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Title: Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite
Authors: Karol Zeleník
Martin Formánek
Radana Walderová
Debora Formánková
Pavel Komínek
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Keyword: Autologous Fat
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06479-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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