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European Archives of Oto-Rhino-Laryngology

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01-07-2016 | Otology

In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants

Authors: Ya Liu, Claude Jolly, Susanne Braun, Thomas Stark, Elias Scherer, Stefan K. Plontke, Jan Kiefer

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2016

Abstract

Cochlear implants have been widely used for patients with profound hearing loss and partial deafness. Residual low-frequency hearing, however, may deteriorate due to insertion trauma and tissue response around the electrode array. The present study investigated in vitro and in vivo release of dexamethasone from silicone used for cochlear implant electrode carriers. The in vitro experiment involved an apparatus simulating the inner ear fluid environment in humans. Release from two sizes of silicone films (200 µm × 1 mm × 10 mm and 500 µm × 1 mm × 10 mm), each loaded with 2 % dexamethasone, and was measured for 24 weeks. In the in vivo experiment, silicone rods loaded with 2 or 10 % dexamethasone, respectively, were implanted into the scala tympani of guinea pigs. Perilymph concentrations were measured during the first week after implantation. The results showed that dexamethasone was released from the silicone in a sustained manner. After a burst release, perilymph concentration was similar for silicone incorporated with 2 and 10 % dexamethasone, respectively. The similar pharmacokinetic profile was found in the in vitro experiment. The period of sustained drug delivery was maintained for 20 weeks in vitro and for 1 week in vivo. The results of the present study suggest that drugs like dexamethasone are released in a controlled manner from silicon electrode carriers of cochlear implants. Further studies will identify optimal release profiles for the use with cochlear implants to improve their safety and long-term performance.

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Title: In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants
Authors: Ya Liu
Claude Jolly
Susanne Braun
Thomas Stark
Elias Scherer
Stefan K. Plontke
Jan Kiefer
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3760-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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