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European Archives of Oto-Rhino-Laryngology

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01-02-2013 | Head and Neck

Prognostic significance of nodal ratio in cutaneous squamous cell carcinoma of the head and neck

Authors: Aviram Mizrachi, Tuvia Hadar, Naomi Rabinovics, Thomas Shpitzer, Dan Guttman, Raphael Feinmesser, Gideon Bachar

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2013

Abstract

The TNM classification is not specific for head and neck skin cancer and makes no allowance for disease extent. Studies have shown that the relative number of metastatic-to-examined lymph nodes, termed the Nodal ratio, is a reliable independent prognosticator in several types of cancer. The study was designed as a retrospective analysis in a university affiliated tertiary care center setting. The files of all patients (n = 71) with cutaneous head and neck squamous cell carcinoma and regional lymph node metastasis who attended a tertiary medical center between 1990 and 2008 were reviewed for clinical variables and outcome, and Nodal ratio was calculated. Data were analyzed for impact on survival. On multivariate analysis Nodal ratio and age were found to be significant predictors of overall survival. The N-ratio was the only significant predictor of disease-specific survival. Age, type of treatment (selective/modified neck dissection), pathologic N stage, and radiotherapy had no effect. The Nodal ratio is a potentially valuable prognostic index in cutaneous squamous cell carcinoma. The minimal number of nodes that need to be excised has to be determined.

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Title: Prognostic significance of nodal ratio in cutaneous squamous cell carcinoma of the head and neck
Authors: Aviram Mizrachi
Tuvia Hadar
Naomi Rabinovics
Thomas Shpitzer
Dan Guttman
Raphael Feinmesser
Gideon Bachar
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2050-3

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Prognostic significance of nodal ratio in cutaneous squamous cell carcinoma of the head and neck

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