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European Archives of Oto-Rhino-Laryngology

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01-08-2011 | Head and Neck

Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas

Authors: Marcelo Gadelha Vasconcelos, Pollianna Muniz Alves, Rodrigo Gadelha Vasconcelos, Éricka Janine Dantas da Silveira, Ana Miryam Costa Medeiros, Lélia Maria Guedes de Queiroz

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2011

Abstract

The objective of this study was to assess angiogenic activity by analyzing anti-CD105 and anti-CD34 immunostaining in 20 cases of vascular malformations (VMs) and 20 cases of oral pyogenic granulomas (OPG). In addition, the usefulness of these markers for the differential diagnosis of these two oral tumors was evaluated. The results showed no significant difference in mean microvessel count between the anti-CD105 (P = 0.803) and anti-CD34 (P = 0.279) antibody. The mean number of vessels was 18.75 and 59.72 for oral VMs immunostained with anti-CD105 and anti-CD34 antibody, respectively, whereas in OPG the mean number was 20.22 and 48.09, respectively. CD34 was found to be more effective than CD105 in identifying blood vessels. However, the anti-CD105 antibody seems to be more related to vascular neoformation. Overall, this study supports the role of angiogenic factors in the etiopathogenesis of oral VMs and PG, but the results showed that quantification of angiogenesis cannot be used as a marker for the differential diagnosis of these two types of lesions.

Soares AB, Juliano PB, Araujo VC, Metze K, Altemani A (2007) Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. Virchows Arch 451(1):65–71PubMedCrossRef

Netto GC, Bleil CB, Hilbig A, Coutinho LM (2008) Immunohistochemical evaluation of the microvascular density through the expression of TGF-β (CD105/endoglin) and CD34 receptors and expression of the vascular endothelial growth factor (VEGF) in oligodendrogliomas. Neuropathology 28(1):17–23PubMedCrossRef

Freitas TM, Miguel MC, Silveira EJ, Freitas RA, Galvão HC (2005) Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. Exp Mol Pathol 79(1):79–85PubMedCrossRef

Llorca O, Trujillo A, Blanco FJ, Bernabeu C (2007) Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia. J Mol Biol 365(3):694–705PubMedCrossRef

Heimburg S, Oehler MK, Papadopoulos T, Caffier H, Kristen P, Dietl J (1999) Prognostic relevance of the endothelial marker CD34 in ovarian cancer. Anticancer Res 19(4A):2527–2529PubMed

Buckmiller LM, Richter GT, Suen JY (2010) Diagnosis and management of hemangiomas and vascular malformations of the head and neck. Oral Dis 16:405–418PubMedCrossRef

Maeda K, Chung YS, Takatsuka S, Ogawa Y, Onoda N, Sawada T, Kato Y, Nitta A, Arimoto Y, Kondo Y (1995) Tumor angiogenesis and tumour cell proliferation as prognostic indicator in gastric carcinoma. Br J Cancer 72(2):319–323PubMedCrossRef

Wakulich C, Jackson-Boeters L, Daley TD, Wysocki GP (2002) Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(5):573–579PubMedCrossRef

Guttman D, Stern Y, Shpitzer T, Ulanovski D, Druzd T, Feinmesser R (2004) Expression of MMP-9, TIMP-1, CD34 and factor-8 as prognostic markers for squamous cell carcinoma of the tongue. Oral Oncol 40(8):798–803PubMedCrossRef

10.

Martone T, Rosso P, Albera R, Migliaretti G, Fraire F, Pignataro L, Pruneri G, Bellone G, Cortesina G (2005) Prognostic relevance of CD105⁺ microvessel density in HNSCC patient outcome. Oral Oncol 4(2):147–155CrossRef

11.

Ascani G, Balercia P, Messi M, Lupi L, Goteri G, Filosa A, Stramazzotti D, Pieramici T, Rubini C (2005) Angiogenesis in oral squamous cell carcinoma. Acta Otorhinolaryngol Ital 25(1):13–17PubMed

12.

Nikiteas NI, Tzanakis N, Theodoropoulos G, Atsaves V, Christoni Z, Karakitsos P, Lazaris AC, Papachristodoulou A, Klonaris C, Gazouli M (2007) Vascular endothelial growth factor and endoglin (CD105) in gastric cancer. Gastric Cancer 10(1):12–17PubMedCrossRef

13.

Chuang HC, Su CY, Huang HY, Chien CY, Chen CM, Huang CC (2006) High expression of CD105 as a prognostic predictor of early tongue cancer. Laryngoscope 116(7):1175–1179PubMedCrossRef

14.

Sundine MJ, Garrett A (2007) Hemangiomas: an overview. Clin Pediatr 43(3):206–221CrossRef

15.

Jafarzadeh H, Sanatkhani M, Mohtasham N (2006) Oral pyogenic granuloma: a review. J Oral Sci 48(4):167–175PubMedCrossRef

Title: Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas
Authors: Marcelo Gadelha Vasconcelos
Pollianna Muniz Alves
Rodrigo Gadelha Vasconcelos
Éricka Janine Dantas da Silveira
Ana Miryam Costa Medeiros
Lélia Maria Guedes de Queiroz
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 8/2011
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1472-z

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Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas

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