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European Archives of Oto-Rhino-Laryngology

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Open Access 01-12-2010 | Review Article

Current treatment options for recurrent nasopharyngeal cancer

Authors: Carlos Suárez, Juan P. Rodrigo, Alessandra Rinaldo, Johannes A. Langendijk, Ashok R. Shaha, Alfio Ferlito

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2010

Abstract

Loco-regional control rate of nasopharyngeal carcinoma (NPC) has improved significantly in the past decade. However, local recurrence still represents a major cause of mortality and morbidity in advanced stages, and management of local failure remains a challenging issue in NPC. The best salvage treatment for local recurrent NPC remains to be determined. The options include brachytherapy, external radiotherapy, stereotactic radiosurgery, and nasopharyngectomy, either alone or in different combinations. In this article we will discuss the different options for salvage of locally recurrent NPC. Retreatment of locally recurrent NPC using radiotherapy, alone or in combination with other treatment modalities, as well as surgery, can result in long-term local control and survival in a substantial proportion of patients. For small-volume recurrent tumors (T1–T2) treated with external radiotherapy, brachytherapy or stereotactic radiosurgery, comparable results to those obtained with surgery have been reported. In contrast, treatment results of advanced-stage locally recurrent NPC are generally more satisfactory with surgery (with or without postoperative radiotherapy) than with reirradiation.

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Title: Current treatment options for recurrent nasopharyngeal cancer
Authors: Carlos Suárez
Juan P. Rodrigo
Alessandra Rinaldo
Johannes A. Langendijk
Ashok R. Shaha
Alfio Ferlito
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 12/2010
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1385-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Current treatment options for recurrent nasopharyngeal cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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