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European Archives of Oto-Rhino-Laryngology

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Open Access 01-02-2011 | Laryngology

Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis

Authors: Alicja Grzanka, Maciej Misiołek, Wojciech Golusiński, Jerzy Jarząb

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2011

Abstract

Intra-nasal glucocorticoids are the most effective drugs available for rhinosinusitis and nasal polyposis treatment. Their effectiveness depends on many factors and not all of them have been well recognized so far. The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators. They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge. Discovery of nongenomic glucocorticoid actions allows for better use of these drugs in clinical practice.

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Title: Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis
Authors: Alicja Grzanka
Maciej Misiołek
Wojciech Golusiński
Jerzy Jarząb
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2011
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1330-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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