Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-08-2009 | Laryngology

Incidence and treatment results of laryngopharyngeal reflux in chronic obstructive pulmonary disease

Authors: Emel Eryuksel, Muzeyyen Dogan, Sehnaz Olgun, Ismail Kocak, Turgay Celikel

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2009

Abstract

Laryngopharyngeal reflux (LPR) is defined as the movement of gastric content towards the larynx and the pharynx and it may cause respiratory symptoms or difficulty in their control. We aimed to find the frequency of LPR in chronic obstructive pulmonary disease (COPD) patients and to investigate its effect on COPD symptoms and the results of its treatment. At baseline 30 (20 male, 10 female, mean age: 65 ± 10 years) COPD patients completed LPR and COPD symptom questionnaires and 13 (44%) were diagnosed with LPR based on laryngeal examination. Patients with LPR were given 2 months of PPI treatment, after which LPR and COPD symptom questionnaires, laryngeal examinations and pulmonary function tests were repeated. Following the treatment, significant improvements in COPD symptom index, LPR symptom index and laryngeal examination findings were observed in patients with LPR (P < 0.01, P < 0.01, P < 0.0001, respectively). Treatment of LPR resulted in a significant improvement in the symptoms of COPD.

Koufman JA, Aviv JE, Casiano RR et al (2002) Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 127:32–35CrossRefPubMed

Koufman JA (2002) Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J 81:7–9PubMed

Cohen JT, Bach KK, Postma GN et al (2002) Clinical manifestations of laryngopharyngeal reflux. Ear Nose Throat J 81:19–23PubMed

Boyle JT, Tuchman DN, Altschuler SM et al (1985) Mechanisms for the association of gastroesophageal reflux and bronchospasm. Am Rev Respir Dis 131:16–20

Mansfield LE, Stein MR (1978) Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy 41:224–226PubMed

Orr WC, Shamma-Othman Z, Allen M et al (1992) Esophageal function and gastroesophageal reflux during sleep and waking in patients with chronic obstructive pulmonary disease. Chest 101:1521–1525CrossRefPubMed

Stein MR, Towner TG, Weber RW et al (1980) The effect of theophylline on the lower esophageal sphincter pressure. Ann Allergy 45:238–241PubMed

Crowell MD, Zayat EN, Lacy BE et al (2001) The effects of an inhaled beta (2)-adrenergic agonist on lower esophageal function: a dose–response study. Chest 120:1184–1189CrossRefPubMed

Zheng Z, Nordenstedt H, Pedersen NL et al (2007) Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins. Gastroenterology 132:87–95CrossRefPubMed

10.

Nilsson M, Johnsen R, Ye W et al (2004) Lifestyle-related risk factors in the aetiology of gastro-oesophageal reflux. Gut 53:1730–1735CrossRefPubMedPubMedCentral

11.

Nocon M, Labenz J, Willich SN (2006) Lifestyle factors and symptoms of gastro-oesophageal reflux a population-based study. Aliment Pharmacol Ther 23:169–174CrossRefPubMed

12.

Tutuian R, Castell DO (2004) Diagnosis of laryngopharyngeal reflux. Curr Opin Otolaryngol Head Neck Surg 12:174–179CrossRefPubMed

13.

Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the reflux symptom index. J Voice 16:274–277CrossRefPubMed

14.

D’Ovidio F, Singer LG, Hadjiliadis D et al (2005) Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 80:1254–1260CrossRefPubMed

15.

Kempainen RR, Savik K, Whelan TP et al (2007) High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD. Chest 131(6):1666–1671CrossRefPubMed

16.

American Thoracic Society (1995) Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 152:77–121

17.

Anthonisen NR, Manfreda J, Warren CP et al (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106:196–204CrossRefPubMed

18.

Belafsky PC, Postma GN, Koufman JA (2001) The validity and reliability of the reflux finding score. Laryngoscope 111:1313–1317CrossRefPubMed

19.

Casanova C, Baudet JS, e Velasco M et al (2004) Increased gastro-oesophageal reflux disease in patients with severe COPD. Eur Respir J 23:841–845CrossRefPubMed

20.

Belafsky PC, Postma GN, Amin MR et al (2002) Symptoms and findings of laryngopharyngeal reflux. Ear Nose Throat J 81:10–13PubMed

21.

Postma GN, Belafsky PC, Aviv JE et al (2002) Laryngopharyngeal reflux testing. Ear Nose Throat J 81:14–18PubMed

22.

Katz PO (1990) Ambulatory esophageal and hypopharyngeal pH monitoring in patients with hoarseness. Am J Gastroenterol 85:38–40PubMed

23.

Dagli S, Dagli U, Kurtaran H et al (2004) Laryngopharyngeal reflux in laryngeal cancer. Turk J Gastroenterol 15:77–81PubMed

24.

Mokhlesi B, Morris AL, Huang CF et al (2001) Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest 119:1043–1048CrossRefPubMed

25.

Rascon-Aguilar IE, Pamer M, Wludyka P et al (2006) Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest 130:1096–1101CrossRefPubMed

26.

Eryuksel E, Dogan M, Golabi P et al (2006) Treatment of laryngopharyngeal reflux improves asthma symptoms in asthmatics. J Asthma 43:539–542CrossRefPubMed

27.

Mjönes AB, Ledin T, Grahn LT et al (2005) Hoarseness and misdirected swallowing before and after antireflux surgery. Acta Otolaryngol 125:82–85CrossRefPubMed

Title: Incidence and treatment results of laryngopharyngeal reflux in chronic obstructive pulmonary disease
Authors: Emel Eryuksel
Muzeyyen Dogan
Sehnaz Olgun
Ismail Kocak
Turgay Celikel
Publication date: 01-08-2009
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 8/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-009-0922-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Incidence and treatment results of laryngopharyngeal reflux in chronic obstructive pulmonary disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2009

Dual-energy X-ray absorptiometry analysis of body composition in patients affected by OSAS

CT morphological evaluation of anterior epitympanic recess in patients with attic cholesteatoma

Control of bleeding following functional endoscopic sinus surgery using carboxy-methylated cellulose packing

Comparison of clinical and histopathological evaluation of tonsils in pediatric and adult patients

Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial)

Antrochoanal polyp: a comparative study of endoscopic endonasal surgery alone and endoscopic endonasal plus mini-Caldwell technique