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European Archives of Oto-Rhino-Laryngology

Published in:

01-01-2009 | Review Article

An overview of the etiology of otosclerosis

Authors: Konstantinos Markou, John Goudakos

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2009

Abstract

Otosclerosis is the primary disease affecting the homeostasis of otic capsule and is among the most common causes of acquired hearing loss. Otosclerosis is considered as a multifactor disease, caused by both genetic and environmental factors. The aim of the present review is to summarize and analyze the bibliographic data, associated with the etiology of the disease. In some cases, the otosclerosis has an autosomal dominant mode of inheritance with incomplete penetrance. Genetic studies reveal the occurrence of at least nine chromosomal loci as candidate genes of the disease. The localized measles virus infection of the otic capsule has been postulated as a possible etiological theory. The role of hormonal factors, immune and bone-remodeling system in the etiopathogenesis of otosclerosis and the association of the disease with the disorders of the connective tissue are the issues of the present study. Despite the extensive research, many etiological factors and theories have been suggested and the process of development of the otosclerosis remains unclear.

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Title: An overview of the etiology of otosclerosis
Authors: Konstantinos Markou
John Goudakos
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-008-0790-x

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An overview of the etiology of otosclerosis

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