Published in:
01-08-2019 | Endometrial Cancer | Review
Type-II endometrial cancer: role of adipokines
Authors:
Kusuma Kumari Garikapati, V. V. V. Ravi Kiran Ammu, Praveen T. Krishnamurthy, Pavan Kumar Chintamaneni, Sai Kiran S. S. Pindiprolu
Published in:
Archives of Gynecology and Obstetrics
|
Issue 2/2019
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Abstract
Background
Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.
Areas covered
This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.
Conclusion
In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.