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Published in: Archives of Gynecology and Obstetrics 2/2019

01-08-2019 | Endometrial Cancer | Review

Type-II endometrial cancer: role of adipokines

Authors: Kusuma Kumari Garikapati, V. V. V. Ravi Kiran Ammu, Praveen T. Krishnamurthy, Pavan Kumar Chintamaneni, Sai Kiran S. S. Pindiprolu

Published in: Archives of Gynecology and Obstetrics | Issue 2/2019

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Abstract

Background

Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.

Areas covered

This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.

Conclusion

In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.
Literature
5.
6.
go back to reference Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95:1218–1226CrossRefPubMed Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95:1218–1226CrossRefPubMed
13.
go back to reference Berstein LM, Santen RJ (2008) Innovative endocrinology of cancer. Springer, New YorkCrossRef Berstein LM, Santen RJ (2008) Innovative endocrinology of cancer. Springer, New YorkCrossRef
16.
go back to reference Tashiro H, Isacson C, Levine R et al (1997) p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Am J Pathol 150:177–185PubMedPubMedCentral Tashiro H, Isacson C, Levine R et al (1997) p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Am J Pathol 150:177–185PubMedPubMedCentral
17.
go back to reference Lax SF, Kendall B, Tashiro H et al (2000) The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 88:814–824CrossRefPubMed Lax SF, Kendall B, Tashiro H et al (2000) The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 88:814–824CrossRefPubMed
22.
go back to reference Caduff RF, Johnston CM, Frank TS (1995) Mutations of the Ki-ras oncogene in carcinoma of the endometrium. Am J Pathol 146:182–188PubMedPubMedCentral Caduff RF, Johnston CM, Frank TS (1995) Mutations of the Ki-ras oncogene in carcinoma of the endometrium. Am J Pathol 146:182–188PubMedPubMedCentral
26.
go back to reference Mutter GL, Lin MC, Fitzgerald JT et al (2000) Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 92:924–930CrossRefPubMed Mutter GL, Lin MC, Fitzgerald JT et al (2000) Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 92:924–930CrossRefPubMed
29.
go back to reference Fukuchi T, Sakamoto M, Tsuda H et al (1998) Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res 58:3526–3528PubMed Fukuchi T, Sakamoto M, Tsuda H et al (1998) Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res 58:3526–3528PubMed
30.
go back to reference Palacios J, Catasús L, Moreno-Bueno G et al (2001) Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability. Virchows Arch Int J Pathol 438:464–469CrossRef Palacios J, Catasús L, Moreno-Bueno G et al (2001) Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability. Virchows Arch Int J Pathol 438:464–469CrossRef
34.
go back to reference Rodriguez C, Calle EE, Fakhrabadi-Shokoohi D et al (2002) Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 11:822–828 Rodriguez C, Calle EE, Fakhrabadi-Shokoohi D et al (2002) Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 11:822–828
37.
go back to reference Takeda K, Sagawa Y, Arakawa T (1970) Therapeutic effect of bleomycin for skin tumors. Gan 61:207–218PubMed Takeda K, Sagawa Y, Arakawa T (1970) Therapeutic effect of bleomycin for skin tumors. Gan 61:207–218PubMed
40.
go back to reference Treas J, Tyagi T, Singh KP (2013) Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1: MLH1 Hypermethylation in Prostate Cancer. Prostate. https://doi.org/10.1002/pros.22701 CrossRefPubMed Treas J, Tyagi T, Singh KP (2013) Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1: MLH1 Hypermethylation in Prostate Cancer. Prostate. https://​doi.​org/​10.​1002/​pros.​22701 CrossRefPubMed
43.
go back to reference Paz-Filho G, Lim EL, Wong ML, Licinio J (2011) Associations between adipokines and obesity-related cancer. Front Biosci Landmark Ed 16:1634–1650CrossRefPubMed Paz-Filho G, Lim EL, Wong ML, Licinio J (2011) Associations between adipokines and obesity-related cancer. Front Biosci Landmark Ed 16:1634–1650CrossRefPubMed
50.
go back to reference Völkl A, Ule G (1972) Trace elements in human brain. Iron concentration of 13 brain areas as a function of age. Z Neurol 202:331–338PubMed Völkl A, Ule G (1972) Trace elements in human brain. Iron concentration of 13 brain areas as a function of age. Z Neurol 202:331–338PubMed
59.
go back to reference Baratta M (2002) Leptin—from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit Int Med J Exp Clin Res 8:RA282–RA292 Baratta M (2002) Leptin—from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit Int Med J Exp Clin Res 8:RA282–RA292
65.
go back to reference Frankenberry KA, Skinner H, Somasundar P et al (2006) Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28:985–993PubMed Frankenberry KA, Skinner H, Somasundar P et al (2006) Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28:985–993PubMed
67.
go back to reference T Jardé S Perrier MP Vasson F Caldefie-Chézet 2011 Molecular mechanisms of leptin and adiponectin in breast cancer Eur J Cancer Oxf Engl 47 33 43 10.1016/j.ejca.2010.09.005 T Jardé S Perrier MP Vasson F Caldefie-Chézet 2011 Molecular mechanisms of leptin and adiponectin in breast cancer Eur J Cancer Oxf Engl 47 33 43 10.1016/j.ejca.2010.09.005
69.
go back to reference Kaser S, Kaser A, Sandhofer A et al (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun 309:286–290CrossRefPubMed Kaser S, Kaser A, Sandhofer A et al (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun 309:286–290CrossRefPubMed
71.
go back to reference KF Yoong G McNab SG Hübscher DH Adams 1998 Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma J Immunol Baltim Md 160 3978 3988 KF Yoong G McNab SG Hübscher DH Adams 1998 Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma J Immunol Baltim Md 160 3978 3988
73.
go back to reference Johnson JP (1999) Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 18:345–357CrossRefPubMed Johnson JP (1999) Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 18:345–357CrossRefPubMed
76.
go back to reference Samal B, Sun Y, Stearns G et al (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14:1431–1437CrossRefPubMedPubMedCentral Samal B, Sun Y, Stearns G et al (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14:1431–1437CrossRefPubMedPubMedCentral
77.
go back to reference Preiss J, Handler P (1957) Enzymatic synthesis of nicotinamide mononucleotide. J Biol Chem 225:759–770PubMed Preiss J, Handler P (1957) Enzymatic synthesis of nicotinamide mononucleotide. J Biol Chem 225:759–770PubMed
82.
go back to reference Tokmak A, Kokanali MK, Guzel AI et al (2014) Polycystic ovary syndrome and risk of endometrial cancer: a mini-review. Asian Pac J Cancer Prev APJCP 15:7011–7014CrossRefPubMed Tokmak A, Kokanali MK, Guzel AI et al (2014) Polycystic ovary syndrome and risk of endometrial cancer: a mini-review. Asian Pac J Cancer Prev APJCP 15:7011–7014CrossRefPubMed
86.
go back to reference Buldak RJ, Gowarzewski M, Buldak L et al (2015) Viability and oxidative response of human colorectal HCT-116 cancer cells treated with visfatin/eNampt in vitro. J Physiol Pharmacol Off J Pol Physiol Soc 66:557–566 Buldak RJ, Gowarzewski M, Buldak L et al (2015) Viability and oxidative response of human colorectal HCT-116 cancer cells treated with visfatin/eNampt in vitro. J Physiol Pharmacol Off J Pol Physiol Soc 66:557–566
89.
go back to reference Hotta K, Funahashi T, Bodkin NL et al (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126–1133CrossRefPubMed Hotta K, Funahashi T, Bodkin NL et al (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126–1133CrossRefPubMed
Metadata
Title
Type-II endometrial cancer: role of adipokines
Authors
Kusuma Kumari Garikapati
V. V. V. Ravi Kiran Ammu
Praveen T. Krishnamurthy
Pavan Kumar Chintamaneni
Sai Kiran S. S. Pindiprolu
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 2/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-019-05181-1

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