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Published in: Archives of Gynecology and Obstetrics 1/2017

01-07-2017 | Review

Current strategies in the diagnosis of endometrial cancer

Authors: Tamar Tzur, Roi Kessous, Adi Y. Weintraub

Published in: Archives of Gynecology and Obstetrics | Issue 1/2017

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Abstract

Purpose

Endometrial cancer is the most common gynecological malignancy in developed countries. There are no uniform recommendations for endometrial cancer screening in the general population. Therefore, it is of paramount importance that the primary physician profoundly understands, and is familiar with the methods for prevention and early detection of endometrial cancer. The aim of this review is to provide the primary physician with a toolbox to reach these goals.

Methods

We performed a systemic review to summarize the current strategies to diagnose and prevent endometrial cancer. Many published articles from the last years were identified and included.

Results

A systematic review that summarizes the important subjects in the diagnosis and prevention of endometrial cancer.

Conclusion

Maintaining a high index of suspicion and obtaining endometrial biopsies from all suspected patients is the key for achieving a timely diagnosis.
Literature
1.
go back to reference Committee A, ACOG Committee Opinion (2003) Routine cancer screening. Number 247, December 2000. Int J Gynaecol Obstet 82(2):241–245CrossRef Committee A, ACOG Committee Opinion (2003) Routine cancer screening. Number 247, December 2000. Int J Gynaecol Obstet 82(2):241–245CrossRef
2.
go back to reference Smith RA, Cokkinides V (2005) Eyre HJ (2005) American Cancer Society guidelines for the early detection of cancer. CA Cancer J Clin 55(1):31–44 (quiz 55–56) PubMedCrossRef Smith RA, Cokkinides V (2005) Eyre HJ (2005) American Cancer Society guidelines for the early detection of cancer. CA Cancer J Clin 55(1):31–44 (quiz 55–56) PubMedCrossRef
4.
go back to reference Weiss NS, Szekely DR, Austin DF (1976) Increasing incidence of endometrial cancer in the United States. N Engl J Med 294(23):1259–1262PubMedCrossRef Weiss NS, Szekely DR, Austin DF (1976) Increasing incidence of endometrial cancer in the United States. N Engl J Med 294(23):1259–1262PubMedCrossRef
5.
go back to reference Ziel HK, Finkle WD (1975) Increased risk of endometrial carcinoma among users of conjugated estrogens. N Engl J Med 293(23):1167–1170PubMedCrossRef Ziel HK, Finkle WD (1975) Increased risk of endometrial carcinoma among users of conjugated estrogens. N Engl J Med 293(23):1167–1170PubMedCrossRef
6.
go back to reference Smith DC et al (1975) Association of exogenous estrogen and endometrial carcinoma. N Engl J Med 293(23):1164–1167PubMedCrossRef Smith DC et al (1975) Association of exogenous estrogen and endometrial carcinoma. N Engl J Med 293(23):1164–1167PubMedCrossRef
8.
go back to reference Austin DF, Roe KM (1982) The decreasing incidence of endometrial cancer: public health implications. Am J Publ Health 72(1):65–68CrossRef Austin DF, Roe KM (1982) The decreasing incidence of endometrial cancer: public health implications. Am J Publ Health 72(1):65–68CrossRef
10.
go back to reference Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591PubMedCrossRef Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591PubMedCrossRef
11.
go back to reference Lindemann K et al (2010) Endometrial cancer incidence trends in Norway during 1953-2007 and predictions for 2008-2027. Int J Cancer 127(11):2661–2668PubMedCrossRef Lindemann K et al (2010) Endometrial cancer incidence trends in Norway during 1953-2007 and predictions for 2008-2027. Int J Cancer 127(11):2661–2668PubMedCrossRef
12.
go back to reference Gao Y et al (2016) The prevalence of endometrial cancer in pre- and postmenopausal Chinese women. Menopause Gao Y et al (2016) The prevalence of endometrial cancer in pre- and postmenopausal Chinese women. Menopause
13.
go back to reference Jamison PM et al (2013) Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992–2008. Cancer Epidemiol Biomark Prev 22(2):233–241CrossRef Jamison PM et al (2013) Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992–2008. Cancer Epidemiol Biomark Prev 22(2):233–241CrossRef
15.
go back to reference Hill HA et al (1996) Racial differences in endometrial cancer survival: the black/white cancer survival study. Obstet Gynecol 88(6):919–926PubMedCrossRef Hill HA et al (1996) Racial differences in endometrial cancer survival: the black/white cancer survival study. Obstet Gynecol 88(6):919–926PubMedCrossRef
16.
go back to reference Sonoda Y, Barakat RR (2006) Screening and the prevention of gynecologic cancer: endometrial cancer. Best Pract Res Clin Obstet Gynaecol 20(2):363–377PubMedCrossRef Sonoda Y, Barakat RR (2006) Screening and the prevention of gynecologic cancer: endometrial cancer. Best Pract Res Clin Obstet Gynaecol 20(2):363–377PubMedCrossRef
17.
go back to reference Brinton LA et al (2013) Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial. Gynecol Oncol 129(2):277–284PubMedPubMedCentralCrossRef Brinton LA et al (2013) Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial. Gynecol Oncol 129(2):277–284PubMedPubMedCentralCrossRef
18.
20.
21.
go back to reference Matias-Guiu X, Prat J (2013) Molecular pathology of endometrial carcinoma. Histopathology 62(1):111–123PubMedCrossRef Matias-Guiu X, Prat J (2013) Molecular pathology of endometrial carcinoma. Histopathology 62(1):111–123PubMedCrossRef
22.
go back to reference Sherman ME (2000) Theories of endometrial carcinogenesis: a multidisciplinary approach. Mod Pathol 13(3):295–308PubMedCrossRef Sherman ME (2000) Theories of endometrial carcinogenesis: a multidisciplinary approach. Mod Pathol 13(3):295–308PubMedCrossRef
23.
24.
go back to reference Armstrong AJ et al (2012) Diagnosis and management of endometrial hyperplasia. J Minim Invasive Gynecol 19(5):562–571PubMedCrossRef Armstrong AJ et al (2012) Diagnosis and management of endometrial hyperplasia. J Minim Invasive Gynecol 19(5):562–571PubMedCrossRef
25.
go back to reference Gol K et al (2001) Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women. Gynecol Endocrinol 15(1):63–67PubMedCrossRef Gol K et al (2001) Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women. Gynecol Endocrinol 15(1):63–67PubMedCrossRef
26.
go back to reference Ash SJ, Farrell SA, Flowerdew G (1996) Endometrial biopsy in DUB. J Reprod Med 41(12):892–896PubMed Ash SJ, Farrell SA, Flowerdew G (1996) Endometrial biopsy in DUB. J Reprod Med 41(12):892–896PubMed
27.
go back to reference Park JC et al (2011) Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. Clin Exp Reprod Med 38(1):42–46PubMedPubMedCentralCrossRef Park JC et al (2011) Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. Clin Exp Reprod Med 38(1):42–46PubMedPubMedCentralCrossRef
28.
go back to reference Baak JP et al (2005) The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 103(11):2304–2312PubMedPubMedCentralCrossRef Baak JP et al (2005) The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 103(11):2304–2312PubMedPubMedCentralCrossRef
29.
go back to reference Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer 56(2):403–412PubMedCrossRef Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer 56(2):403–412PubMedCrossRef
30.
go back to reference Zaino RJ et al (2006) Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer 106(4):804–811PubMedCrossRef Zaino RJ et al (2006) Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer 106(4):804–811PubMedCrossRef
31.
go back to reference Salman MC et al (2010) Comparison of WHO and endometrial intraepithelial neoplasia classifications in predicting the presence of coexistent malignancy in endometrial hyperplasia. J Gynecol Oncol 21(2):97–101PubMedPubMedCentralCrossRef Salman MC et al (2010) Comparison of WHO and endometrial intraepithelial neoplasia classifications in predicting the presence of coexistent malignancy in endometrial hyperplasia. J Gynecol Oncol 21(2):97–101PubMedPubMedCentralCrossRef
32.
33.
go back to reference The Writing Group for the PEPI Trial (1996) Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 275(5):370–375CrossRef The Writing Group for the PEPI Trial (1996) Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 275(5):370–375CrossRef
34.
go back to reference Herrinton LJ, Weiss NS (1993) Postmenopausal unopposed estrogens. Characteristics of use in relation to the risk of endometrial carcinoma. Ann Epidemiol 3(3):308–318PubMedCrossRef Herrinton LJ, Weiss NS (1993) Postmenopausal unopposed estrogens. Characteristics of use in relation to the risk of endometrial carcinoma. Ann Epidemiol 3(3):308–318PubMedCrossRef
35.
go back to reference Archer DF (2001) The effect of the duration of progestin use on the occurrence of endometrial cancer in postmenopausal women. Menopause 8(4):245–251PubMedCrossRef Archer DF (2001) The effect of the duration of progestin use on the occurrence of endometrial cancer in postmenopausal women. Menopause 8(4):245–251PubMedCrossRef
36.
go back to reference Pike MC et al (1997) Estrogen-progestin replacement therapy and endometrial cancer. J Natl Cancer Inst 89(15):1110–1116PubMedCrossRef Pike MC et al (1997) Estrogen-progestin replacement therapy and endometrial cancer. J Natl Cancer Inst 89(15):1110–1116PubMedCrossRef
37.
go back to reference Anderson GL et al (2003) Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women’s Health Initiative randomized trial. JAMA 290(13):1739–1748PubMedCrossRef Anderson GL et al (2003) Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women’s Health Initiative randomized trial. JAMA 290(13):1739–1748PubMedCrossRef
38.
go back to reference Mourits MJ et al (2001) Tamoxifen treatment and gynecologic side effects: a review. Obstet Gynecol 97(5 Pt 2):855–866PubMed Mourits MJ et al (2001) Tamoxifen treatment and gynecologic side effects: a review. Obstet Gynecol 97(5 Pt 2):855–866PubMed
39.
go back to reference Killackey MA, Hakes TB, Pierce VK (1985) Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens. Cancer Treat Rep 69(2):237–238PubMed Killackey MA, Hakes TB, Pierce VK (1985) Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens. Cancer Treat Rep 69(2):237–238PubMed
40.
go back to reference Iqbal J et al (2012) Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review. Cancer Treat Rev 38(4):318–328PubMedCrossRef Iqbal J et al (2012) Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review. Cancer Treat Rev 38(4):318–328PubMedCrossRef
41.
go back to reference Early Breast Cancer Trialists’ Collaborative G et al (2011) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 378(9793):771–784CrossRef Early Breast Cancer Trialists’ Collaborative G et al (2011) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 378(9793):771–784CrossRef
42.
go back to reference Committee on Practice B.-G. (2012) ACOG practice bulletin no. 126: Management of gynecologic issues in women with breast cancer. Obstet Gynecol 119(3):666–682CrossRef Committee on Practice B.-G. (2012) ACOG practice bulletin no. 126: Management of gynecologic issues in women with breast cancer. Obstet Gynecol 119(3):666–682CrossRef
43.
go back to reference Zeleniuch-Jacquotte A et al (2001) Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study. Br J Cancer 84(7):975–981PubMedPubMedCentralCrossRef Zeleniuch-Jacquotte A et al (2001) Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study. Br J Cancer 84(7):975–981PubMedPubMedCentralCrossRef
44.
go back to reference Lukanova A et al (2004) Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer 108(3):425–432PubMedCrossRef Lukanova A et al (2004) Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer 108(3):425–432PubMedCrossRef
45.
go back to reference Hardiman P, Pillay OC, Atiomo W (2003) Polycystic ovary syndrome and endometrial carcinoma. Lancet 361(9371):1810–1812PubMedCrossRef Hardiman P, Pillay OC, Atiomo W (2003) Polycystic ovary syndrome and endometrial carcinoma. Lancet 361(9371):1810–1812PubMedCrossRef
46.
go back to reference Gadducci A et al (2005) Polycystic ovary syndrome and gynecological cancers: is there a link? Gynecol Endocrinol 20(4):200–208PubMedCrossRef Gadducci A et al (2005) Polycystic ovary syndrome and gynecological cancers: is there a link? Gynecol Endocrinol 20(4):200–208PubMedCrossRef
47.
go back to reference Giudice LC (2006) Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab 20(2):235–244PubMedCrossRef Giudice LC (2006) Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab 20(2):235–244PubMedCrossRef
48.
go back to reference Brinton LA et al (1992) Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol 167(5):1317–1325PubMedCrossRef Brinton LA et al (1992) Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol 167(5):1317–1325PubMedCrossRef
49.
go back to reference Xu WH et al (2004) Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai. Int J Cancer 108(4):613–619PubMedCrossRef Xu WH et al (2004) Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai. Int J Cancer 108(4):613–619PubMedCrossRef
50.
go back to reference Zhang Y et al (2010) The association between metabolic abnormality and endometrial cancer: a large case-control study in China. Gynecol Oncol 117(1):41–46PubMedCrossRef Zhang Y et al (2010) The association between metabolic abnormality and endometrial cancer: a large case-control study in China. Gynecol Oncol 117(1):41–46PubMedCrossRef
51.
go back to reference Noto H et al (2010) Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications 24(5):345–353PubMedCrossRef Noto H et al (2010) Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications 24(5):345–353PubMedCrossRef
52.
go back to reference Soliman PT et al (2006) Association between adiponectin, insulin resistance, and endometrial cancer. Cancer 106(11):2376–2381PubMedCrossRef Soliman PT et al (2006) Association between adiponectin, insulin resistance, and endometrial cancer. Cancer 106(11):2376–2381PubMedCrossRef
53.
go back to reference Friberg E et al (2007) Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 50(7):1365–1374PubMedCrossRef Friberg E et al (2007) Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 50(7):1365–1374PubMedCrossRef
54.
go back to reference Vrachnis N et al (2016) Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives. Arch Gynecol Obstet 293(2):239–246PubMedCrossRef Vrachnis N et al (2016) Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives. Arch Gynecol Obstet 293(2):239–246PubMedCrossRef
55.
go back to reference Potischman N et al (1996) Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst 88(11):756–758PubMedCrossRef Potischman N et al (1996) Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst 88(11):756–758PubMedCrossRef
56.
go back to reference Renehan AG et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578PubMedCrossRef Renehan AG et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578PubMedCrossRef
57.
go back to reference Pellerin GP, Finan MA (2005) Endometrial cancer in women 45 years of age or younger: a clinicopathological analysis. Am J Obstet Gynecol 193(5):1640–1644PubMedCrossRef Pellerin GP, Finan MA (2005) Endometrial cancer in women 45 years of age or younger: a clinicopathological analysis. Am J Obstet Gynecol 193(5):1640–1644PubMedCrossRef
58.
go back to reference Bharati R et al (2014) Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer? Gynecol Oncol 133(2):287–292PubMedPubMedCentralCrossRef Bharati R et al (2014) Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer? Gynecol Oncol 133(2):287–292PubMedPubMedCentralCrossRef
59.
go back to reference Kitson SJ, Evans DG, Crosbie EJ (2017) Identifying high-risk women for endometrial cancer prevention strategies: proposal of an endometrial cancer risk prediction model. Cancer Prev Res (Phila) 10(1):1–13CrossRef Kitson SJ, Evans DG, Crosbie EJ (2017) Identifying high-risk women for endometrial cancer prevention strategies: proposal of an endometrial cancer risk prediction model. Cancer Prev Res (Phila) 10(1):1–13CrossRef
60.
go back to reference Hampel H (2014) NCCN increases the emphasis on genetic/familial high-risk assessment in colorectal cancer. J Natl Compr Canc Netw 12(5 Suppl):829–831PubMedCrossRef Hampel H (2014) NCCN increases the emphasis on genetic/familial high-risk assessment in colorectal cancer. J Natl Compr Canc Netw 12(5 Suppl):829–831PubMedCrossRef
61.
go back to reference Bonadona V et al (2011) Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA 305(22):2304–2310PubMedCrossRef Bonadona V et al (2011) Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA 305(22):2304–2310PubMedCrossRef
62.
go back to reference Elmasry K et al (2009) Strategies for endometrial screening in the Lynch syndrome population: a patient acceptability study. Fam Cancer 8(4):431–439PubMedCrossRef Elmasry K et al (2009) Strategies for endometrial screening in the Lynch syndrome population: a patient acceptability study. Fam Cancer 8(4):431–439PubMedCrossRef
63.
64.
go back to reference Sehgal R et al (2014) Lynch syndrome: an updated review. Genes (Basel) 5(3):497–507 Sehgal R et al (2014) Lynch syndrome: an updated review. Genes (Basel) 5(3):497–507
65.
go back to reference Vasen HF et al (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116(6):1453–1456PubMedCrossRef Vasen HF et al (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116(6):1453–1456PubMedCrossRef
66.
go back to reference Umar A et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268PubMedPubMedCentralCrossRef Umar A et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268PubMedPubMedCentralCrossRef
67.
go back to reference Tzortzatos G et al (2015) The gynecological surveillance of women with Lynch syndrome in Sweden. Gynecol Oncol Tzortzatos G et al (2015) The gynecological surveillance of women with Lynch syndrome in Sweden. Gynecol Oncol
70.
go back to reference Painter JN et al (2015) Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet 24(5):1478–1492PubMedCrossRef Painter JN et al (2015) Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet 24(5):1478–1492PubMedCrossRef
71.
go back to reference Thompson DJ et al (2016) CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer. Endocr Relat Cancer 23(2):77–91PubMedPubMedCentralCrossRef Thompson DJ et al (2016) CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer. Endocr Relat Cancer 23(2):77–91PubMedPubMedCentralCrossRef
72.
go back to reference Fraser IS et al (2007) A process designed to lead to international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding. Fertil Steril 87(3):466–476PubMedCrossRef Fraser IS et al (2007) A process designed to lead to international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding. Fertil Steril 87(3):466–476PubMedCrossRef
73.
go back to reference American College of O. and Gynecologists (2005) ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol 106(2):413–425CrossRef American College of O. and Gynecologists (2005) ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol 106(2):413–425CrossRef
74.
go back to reference Seebacher V et al (2009) The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study. BMC Cancer 9:460PubMedPubMedCentralCrossRef Seebacher V et al (2009) The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study. BMC Cancer 9:460PubMedPubMedCentralCrossRef
75.
go back to reference Committee on Practice B.-G. (2013) Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol 122(1):176–185CrossRef Committee on Practice B.-G. (2013) Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol 122(1):176–185CrossRef
76.
go back to reference Haidopoulos D et al (2010) Risk factors in women 40 years of age and younger with endometrial carcinoma. Acta Obstet Gynecol Scand 89(10):1326–1330PubMedCrossRef Haidopoulos D et al (2010) Risk factors in women 40 years of age and younger with endometrial carcinoma. Acta Obstet Gynecol Scand 89(10):1326–1330PubMedCrossRef
77.
go back to reference Smith-Bindman R, Weiss E, Feldstein V (2004) How thick is too thick? When endometrial thickness should prompt biopsy in postmenopausal women without vaginal bleeding. Ultrasound Obstet Gynecol 24(5):558–565PubMedCrossRef Smith-Bindman R, Weiss E, Feldstein V (2004) How thick is too thick? When endometrial thickness should prompt biopsy in postmenopausal women without vaginal bleeding. Ultrasound Obstet Gynecol 24(5):558–565PubMedCrossRef
78.
go back to reference Osmers R et al (1989) Vaginosonographic measurement of the postmenopausal endometrium in the early detection of endometrial cancer. Geburtshilfe Frauenheilkd 49(3):262–265PubMedCrossRef Osmers R et al (1989) Vaginosonographic measurement of the postmenopausal endometrium in the early detection of endometrial cancer. Geburtshilfe Frauenheilkd 49(3):262–265PubMedCrossRef
79.
go back to reference Seckin B et al (2016) Diagnostic value of sonography for detecting endometrial pathologies in postmenopausal women with and without bleeding. J Clin Ultrasound Seckin B et al (2016) Diagnostic value of sonography for detecting endometrial pathologies in postmenopausal women with and without bleeding. J Clin Ultrasound
80.
go back to reference Timmermans A et al (2010) Endometrial thickness measurement for detecting endometrial cancer in women with postmenopausal bleeding: a systematic review and meta-analysis. Obstet Gynecol 116(1):160–167PubMedCrossRef Timmermans A et al (2010) Endometrial thickness measurement for detecting endometrial cancer in women with postmenopausal bleeding: a systematic review and meta-analysis. Obstet Gynecol 116(1):160–167PubMedCrossRef
81.
go back to reference Bouzid A, Ayachi A, Mourali M (2015) Value of ultrasonography to predict the endometrial cancer in postmenopausal bleeding. Gynecol Obstet Fertil 43(10):652–658PubMedCrossRef Bouzid A, Ayachi A, Mourali M (2015) Value of ultrasonography to predict the endometrial cancer in postmenopausal bleeding. Gynecol Obstet Fertil 43(10):652–658PubMedCrossRef
82.
go back to reference Sladkevicius P, Valentin L (2016) Prospective validation of two mathematical models to calculate the risk of endometrial malignancy in patients with postmenopausal bleeding and sonographic endometrial thickness ≥4.5 mm. Eur J Cancer 59:179–188PubMedCrossRef Sladkevicius P, Valentin L (2016) Prospective validation of two mathematical models to calculate the risk of endometrial malignancy in patients with postmenopausal bleeding and sonographic endometrial thickness ≥4.5 mm. Eur J Cancer 59:179–188PubMedCrossRef
83.
go back to reference Anastasiadis PG et al (2000) Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol 21(2):180–183PubMed Anastasiadis PG et al (2000) Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol 21(2):180–183PubMed
84.
go back to reference Dreisler E et al (2009) Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20–74 years. Ultrasound Obstet Gynecol 33(1):102–108PubMedCrossRef Dreisler E et al (2009) Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20–74 years. Ultrasound Obstet Gynecol 33(1):102–108PubMedCrossRef
85.
go back to reference Dreisler E et al (2009) Value of endometrial thickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding. Ultrasound Obstet Gynecol 33(3):344–348PubMedCrossRef Dreisler E et al (2009) Value of endometrial thickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding. Ultrasound Obstet Gynecol 33(3):344–348PubMedCrossRef
86.
go back to reference Lieng M et al (2008) Flow differences between endometrial polyps and cancer: a prospective study using intravenous contrast-enhanced transvaginal color flow Doppler and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol 32(7):935–940PubMedCrossRef Lieng M et al (2008) Flow differences between endometrial polyps and cancer: a prospective study using intravenous contrast-enhanced transvaginal color flow Doppler and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol 32(7):935–940PubMedCrossRef
87.
go back to reference Perez-Medina T et al (2002) Predicting atypia inside endometrial polyps. J Ultrasound Med 21(2):125–128PubMedCrossRef Perez-Medina T et al (2002) Predicting atypia inside endometrial polyps. J Ultrasound Med 21(2):125–128PubMedCrossRef
88.
go back to reference Lieng M, Istre O, Qvigstad E (2010) Treatment of endometrial polyps: a systematic review. Acta Obstet Gynecol Scand 89(8):992–1002PubMedCrossRef Lieng M, Istre O, Qvigstad E (2010) Treatment of endometrial polyps: a systematic review. Acta Obstet Gynecol Scand 89(8):992–1002PubMedCrossRef
89.
go back to reference Fischerova D, Cibula D (2015) Ultrasound in gynecological cancer: is it time for re-evaluation of its uses? Curr Oncol Rep 17(6):28PubMedCrossRef Fischerova D, Cibula D (2015) Ultrasound in gynecological cancer: is it time for re-evaluation of its uses? Curr Oncol Rep 17(6):28PubMedCrossRef
90.
go back to reference Fischerova D (2011) Ultrasound scanning of the pelvis and abdomen for staging of gynecological tumors: a review. Ultrasound Obstet Gynecol 38(3):246–266PubMedCrossRef Fischerova D (2011) Ultrasound scanning of the pelvis and abdomen for staging of gynecological tumors: a review. Ultrasound Obstet Gynecol 38(3):246–266PubMedCrossRef
91.
go back to reference Wang Y et al (2014) Time-intensity curve parameters in rectal cancer measured using endorectal ultrasonography with sterile coupling gels filling the rectum: correlations with tumor angiogenesis and clinicopathological features. Biomed Res Int 2014:587806PubMedPubMedCentral Wang Y et al (2014) Time-intensity curve parameters in rectal cancer measured using endorectal ultrasonography with sterile coupling gels filling the rectum: correlations with tumor angiogenesis and clinicopathological features. Biomed Res Int 2014:587806PubMedPubMedCentral
92.
go back to reference Liu Y et al (2016) Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncol Lett 12(5):3763–3770PubMedPubMedCentral Liu Y et al (2016) Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncol Lett 12(5):3763–3770PubMedPubMedCentral
93.
go back to reference Kierans AS et al (2014) Utility of conventional and diffusion-weighted MRI features in distinguishing benign from malignant endometrial lesions. Eur J Radiol 83(4):726–732PubMedCrossRef Kierans AS et al (2014) Utility of conventional and diffusion-weighted MRI features in distinguishing benign from malignant endometrial lesions. Eur J Radiol 83(4):726–732PubMedCrossRef
94.
go back to reference Shen SH et al (2008) Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. AJR Am J Roentgenol 190(2):481–488PubMedCrossRef Shen SH et al (2008) Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. AJR Am J Roentgenol 190(2):481–488PubMedCrossRef
95.
go back to reference Takeuchi M et al (2005) Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. Eur Radiol 15(11):2244–2255PubMedCrossRef Takeuchi M et al (2005) Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. Eur Radiol 15(11):2244–2255PubMedCrossRef
96.
go back to reference Fujii S et al (2008) Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 18(2):384–389PubMedCrossRef Fujii S et al (2008) Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 18(2):384–389PubMedCrossRef
97.
go back to reference Wang J et al (2010) The value of the apparent diffusion coefficient in differentiating stage IA endometrial carcinoma from normal endometrium and benign diseases of the endometrium: initial study at 3-T magnetic resonance scanner. J Comput Assist Tomogr 34(3):332–337PubMedCrossRef Wang J et al (2010) The value of the apparent diffusion coefficient in differentiating stage IA endometrial carcinoma from normal endometrium and benign diseases of the endometrium: initial study at 3-T magnetic resonance scanner. J Comput Assist Tomogr 34(3):332–337PubMedCrossRef
98.
go back to reference Takeuchi M, Matsuzaki K, Nishitani H (2009) Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion. Acta Radiol 50(8):947–953PubMedCrossRef Takeuchi M, Matsuzaki K, Nishitani H (2009) Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion. Acta Radiol 50(8):947–953PubMedCrossRef
99.
go back to reference Bakir B et al (2017) Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening. Clin Imaging 41:86–94PubMedCrossRef Bakir B et al (2017) Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening. Clin Imaging 41:86–94PubMedCrossRef
100.
go back to reference Lai CR, Hsu CY, Li AF (2012) Degenerative necrotic endometrial debris in Papanicolaou smears. The role in the prediction of endometrial pathology. Am J Clin Pathol 137(2):290–294PubMedCrossRef Lai CR, Hsu CY, Li AF (2012) Degenerative necrotic endometrial debris in Papanicolaou smears. The role in the prediction of endometrial pathology. Am J Clin Pathol 137(2):290–294PubMedCrossRef
101.
go back to reference Zhou J, Tomashefski J Jr, Khiyami A (2007) Diagnostic value of the thin-layer, liquid-based Pap test in endometrial cancer: a retrospective study with emphasis on cytomorphologic features. Acta Cytol 51(5):735–741PubMedCrossRef Zhou J, Tomashefski J Jr, Khiyami A (2007) Diagnostic value of the thin-layer, liquid-based Pap test in endometrial cancer: a retrospective study with emphasis on cytomorphologic features. Acta Cytol 51(5):735–741PubMedCrossRef
102.
go back to reference Kir G et al (2014) Significance of foamy histiocytes in cervical smears from postmenopausal women. Acta Cytol 58(1):42–46PubMedCrossRef Kir G et al (2014) Significance of foamy histiocytes in cervical smears from postmenopausal women. Acta Cytol 58(1):42–46PubMedCrossRef
103.
go back to reference Schnatz PF et al (2006) Clinical significance of atypical glandular cells on cervical cytology. Obstet Gynecol 107(3):701–708PubMedCrossRef Schnatz PF et al (2006) Clinical significance of atypical glandular cells on cervical cytology. Obstet Gynecol 107(3):701–708PubMedCrossRef
104.
105.
go back to reference Sams SB, Currens HS, Raab SS (2012) Liquid-based Papanicolaou tests in endometrial carcinoma diagnosis. Performance, error root cause analysis, and quality improvement. Am J Clin Pathol 137(2):248–254PubMedCrossRef Sams SB, Currens HS, Raab SS (2012) Liquid-based Papanicolaou tests in endometrial carcinoma diagnosis. Performance, error root cause analysis, and quality improvement. Am J Clin Pathol 137(2):248–254PubMedCrossRef
106.
go back to reference Serdy K et al (2016) The Value of papanicolaou tests in the diagnosis of endometrial carcinoma: a large study cohort from an Academic Medical Center. Am J Clin Pathol 145(3):350–354PubMedCrossRef Serdy K et al (2016) The Value of papanicolaou tests in the diagnosis of endometrial carcinoma: a large study cohort from an Academic Medical Center. Am J Clin Pathol 145(3):350–354PubMedCrossRef
107.
go back to reference Levine L, Lucci JA 3rd, Dinh TV (2003) Atypical glandular cells: new Bethesda Terminology and Management Guidelines. Obstet Gynecol Surv 58(6):399–406PubMed Levine L, Lucci JA 3rd, Dinh TV (2003) Atypical glandular cells: new Bethesda Terminology and Management Guidelines. Obstet Gynecol Surv 58(6):399–406PubMed
108.
go back to reference Wright TC Jr et al (2007) 2006 consensus guidelines for the management of women with abnormal cervical screening tests. J Low Genit Tract Dis 11(4):201–222PubMedCrossRef Wright TC Jr et al (2007) 2006 consensus guidelines for the management of women with abnormal cervical screening tests. J Low Genit Tract Dis 11(4):201–222PubMedCrossRef
109.
go back to reference Sanam M, Majid MM (2015) Comparison the diagnostic value of dilatation and curettage versus endometrial biopsy by Pipelle: a clinical trial. Asian Pac J Cancer Prev 16(12):4971–4975PubMedCrossRef Sanam M, Majid MM (2015) Comparison the diagnostic value of dilatation and curettage versus endometrial biopsy by Pipelle: a clinical trial. Asian Pac J Cancer Prev 16(12):4971–4975PubMedCrossRef
110.
go back to reference Fakhar S et al (2008) Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding. Ann Saudi Med 28(3):188–191PubMedCrossRef Fakhar S et al (2008) Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding. Ann Saudi Med 28(3):188–191PubMedCrossRef
111.
go back to reference Abdelazim IA, Aboelezz A, Abdulkareem AF (2013) Pipelle endometrial sampling versus conventional dilatation and curettage in patients with abnormal uterine bleeding. J Turk Ger Gynecol Assoc 14(1):1–5PubMedPubMedCentralCrossRef Abdelazim IA, Aboelezz A, Abdulkareem AF (2013) Pipelle endometrial sampling versus conventional dilatation and curettage in patients with abnormal uterine bleeding. J Turk Ger Gynecol Assoc 14(1):1–5PubMedPubMedCentralCrossRef
112.
go back to reference Abdelazim IA et al (2015) Accuracy of endometrial sampling compared to conventional dilatation and curettage in women with abnormal uterine bleeding. Arch Gynecol Obstet 291(5):1121–1126PubMedCrossRef Abdelazim IA et al (2015) Accuracy of endometrial sampling compared to conventional dilatation and curettage in women with abnormal uterine bleeding. Arch Gynecol Obstet 291(5):1121–1126PubMedCrossRef
113.
go back to reference Guido RS et al (1995) Pipelle endometrial sampling. Sensitivity in the detection of endometrial cancer. J Reprod Med 40(8):553–555PubMed Guido RS et al (1995) Pipelle endometrial sampling. Sensitivity in the detection of endometrial cancer. J Reprod Med 40(8):553–555PubMed
114.
115.
go back to reference Epstein E et al (2001) Dilatation and curettage fails to detect most focal lesions in the uterine cavity in women with postmenopausal bleeding. Acta Obstet Gynecol Scand 80(12):1131–1136PubMedCrossRef Epstein E et al (2001) Dilatation and curettage fails to detect most focal lesions in the uterine cavity in women with postmenopausal bleeding. Acta Obstet Gynecol Scand 80(12):1131–1136PubMedCrossRef
116.
go back to reference Gebauer G et al (2001) Role of hysteroscopy in detection and extraction of endometrial polyps: results of a prospective study. Am J Obstet Gynecol 184(2):59–63PubMedCrossRef Gebauer G et al (2001) Role of hysteroscopy in detection and extraction of endometrial polyps: results of a prospective study. Am J Obstet Gynecol 184(2):59–63PubMedCrossRef
Metadata
Title
Current strategies in the diagnosis of endometrial cancer
Authors
Tamar Tzur
Roi Kessous
Adi Y. Weintraub
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 1/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4391-z

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