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01-12-2016 | Gynecologic Oncology

Preoperative local staging of endometrial cancer: the challenge of imaging techniques and serum biomarkers

Authors: Roberto Angioli, Francesco Plotti, Stella Capriglione, Giuseppe Scaletta, Nella Dugo, Alessia Aloisi, Claudia Lucia Piccolo, Riccardo Del Vescovo, Corrado Terranova, Bruno Beomonte Zobel

Published in: Archives of Gynecology and Obstetrics | Issue 6/2016

Abstract

Objective

The aim of this study is to prospectively evaluate and compare the accuracy of high-frequency TVS and of two type of MRI (dynamic contrast-enhanced MRI or diffusion-weighted MRI), in association with HE4 in preoperative endometrial cancer (EC) staging.

Study design

Starting from January 2012 to February 2015, all patients with EC at prior endometrial biopsy, referred to the Division of Gynaecologic Oncology of the University Campus Bio-Medico of Rome, were prospectively included in the study. All of them underwent complete surgical staging hysterectomy and bilateral oophorectomy, pelvic and lumboaortic lymphadenectomy, according to 2011 NCCN guidelines. The day before surgery, patients underwent to transvaginal ultrasonography (TVS), HE4 serum dosage, and using a computer-based random procedure, to dynamic contrast-enhanced MRI (Group A) or to diffusion-weighted MRI (Group B), to assess myometrial invasion and cervical involvement.

Results

Starting from January 2012 to February 2015, a total of 79 patients were considered for the analysis and randomly divided into Group A (n = 38) and Group B (n = 41). Regarding myometrial invasion, MRI and TVS resulted comparable in terms of preoperative detection. Concerning the cervical infiltration, the association between TVS and HE4 is characterized by a better preoperative diagnostic validity (TVS + HE4 96.3 vs. 91 % for MRI and 85 % for the TVS).

Conclusion

Our results, even the low number of enrolled patients, are promising and may lead to a greater efficiency and lower health care costs in identifying those women who require radical surgery and pelvic lymphadenectomy and should be addressed, in specialized centers.

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Title: Preoperative local staging of endometrial cancer: the challenge of imaging techniques and serum biomarkers
Authors: Roberto Angioli
Francesco Plotti
Stella Capriglione
Giuseppe Scaletta
Nella Dugo
Alessia Aloisi
Claudia Lucia Piccolo
Riccardo Del Vescovo
Corrado Terranova
Bruno Beomonte Zobel
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4181-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Preoperative local staging of endometrial cancer: the challenge of imaging techniques and serum biomarkers

Abstract

Objective

Study design

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Study design

Results

Conclusion

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