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Published in: Archives of Gynecology and Obstetrics 4/2016

01-10-2016 | General Gynecology

Impact of endometriosis on surgical outcomes and complications of total laparoscopic hysterectomy

Authors: Stefano Uccella, Nicola Marconi, Jvan Casarin, Marcello Ceccaroni, Luigi Boni, Davide Sturla, Maurizio Serati, Simona Carollo, Carolina Podesta’ Alluvion, Fabio Ghezzi

Published in: Archives of Gynecology and Obstetrics | Issue 4/2016

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Abstract

Purpose

Total laparoscopic hysterectomy (TLH) in the case of endometriosis may be extremely challenging. Our aim has been to analyze perioperative details and complications of TLH in women with vs. women without endometriosis.

Methods

Consecutive women who underwent TLH for endometriosis (endometriosis group) were compared with consecutive patients who had TLH for other conditions (controls) in terms of perioperative outcomes. Patients in the endometriosis group were analyzed, according to the severity of the disease.

Results

One-hundred and twelve women in the endometriosis group, 29 (25.9 %) with minimal–mild, and 83 (74.1 %) with moderate–severe stage disease (rAFS score), respectively, were compared with 572 controls. Conversion rate was 0.8 vs. 0.5 % (P = 0.51), and median operative time was 75 vs. 55 min (pxxx = x) in the endometriosis group vs. controls. Intraoperative complications were similar between groups (P = 0.56). Postoperative complications occurred in 10 (12.3 %) women in the endometriosis group vs. 12 (3.3 %) among the controls (P = 0.002). The severity of complications according to Clavien–Dindo classification system was higher in the endometriosis group (Clavien–Dindo >2: 7.5 vs. 1.9 %). The risk of organ lesions, urinary lesions, postoperative complications, and severe adverse events was significantly higher in women with moderate–severe endometriosis vs. controls. No differences between patients with minimal–mild endometriosis and controls were found.

Conclusion(s)

TLH in the case of endometriosis is associated with longer operative time and an almost fourfold increase in the risk and severity of complications compared with controls. In particular, the adjunctive risk of adverse events is specific for moderate/severe-stage disease but not for minimal/mild endometriosis.
Literature
2.
go back to reference Rana N, Braun DP, House R, Gebel H, Rotman C, Dmowski WP (1996) Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 65:925–930CrossRefPubMed Rana N, Braun DP, House R, Gebel H, Rotman C, Dmowski WP (1996) Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 65:925–930CrossRefPubMed
3.
go back to reference Buck Louis GM, Hediger ML, Peterson CM, Croughan M, Sundaram R, Stanford J, ENDO Study Working Group et al (2011) Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril 96:360–365CrossRefPubMedPubMedCentral Buck Louis GM, Hediger ML, Peterson CM, Croughan M, Sundaram R, Stanford J, ENDO Study Working Group et al (2011) Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril 96:360–365CrossRefPubMedPubMedCentral
4.
go back to reference Eskenazi B, Warner ML (1997) Epidemiology of endometriosis. Obstet Gynecol Clin North Am 24:235–258CrossRefPubMed Eskenazi B, Warner ML (1997) Epidemiology of endometriosis. Obstet Gynecol Clin North Am 24:235–258CrossRefPubMed
5.
go back to reference Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol 83:149–155CrossRefPubMed Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol 83:149–155CrossRefPubMed
6.
go back to reference Bulun SE, Cheng YH, Yin P, Imir G, Utsunomiya H, Attar E et al (2006) Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 248:94–103CrossRefPubMed Bulun SE, Cheng YH, Yin P, Imir G, Utsunomiya H, Attar E et al (2006) Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 248:94–103CrossRefPubMed
7.
go back to reference Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W, European Society of Human Reproduction and Embryology (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29:400–412CrossRefPubMed Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W, European Society of Human Reproduction and Embryology (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29:400–412CrossRefPubMed
8.
go back to reference Vercellini P, Barbara G, Somigliana E, Bianchi S, Abbiati A, Fedele L (2010) Comparison of contraceptive ring and patch for the treatment of symptomatic endometriosis. Fertil Steril 93:2150–2161CrossRefPubMed Vercellini P, Barbara G, Somigliana E, Bianchi S, Abbiati A, Fedele L (2010) Comparison of contraceptive ring and patch for the treatment of symptomatic endometriosis. Fertil Steril 93:2150–2161CrossRefPubMed
9.
go back to reference Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani PG (2003) Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril 80:560–563CrossRefPubMed Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani PG (2003) Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril 80:560–563CrossRefPubMed
10.
go back to reference Koninckx PR, Ussia A, Adamyan L, Wattiez A, Donnez J (2012) Deep endometriosis: definition, diagnosis, and treatment. Fertil Steril 98:564–571CrossRefPubMed Koninckx PR, Ussia A, Adamyan L, Wattiez A, Donnez J (2012) Deep endometriosis: definition, diagnosis, and treatment. Fertil Steril 98:564–571CrossRefPubMed
11.
go back to reference De Cicco C, Corona R, Schonman R, Mailova K, Ussia A, Koninckx P (2011) Bowel resection for deep endometriosis: a systematic review. BJOG 118:285–291CrossRefPubMed De Cicco C, Corona R, Schonman R, Mailova K, Ussia A, Koninckx P (2011) Bowel resection for deep endometriosis: a systematic review. BJOG 118:285–291CrossRefPubMed
14.
go back to reference Bosev D, Nicoll LM, Bhagan L, Lemyre M, Payne CK, Gill H, Nezhat C (2009) Laparoscopic management of ureteral endometriosis: the Stanford University hospital experience with 96 consecutive cases. J Urol 182:2748–2752CrossRefPubMed Bosev D, Nicoll LM, Bhagan L, Lemyre M, Payne CK, Gill H, Nezhat C (2009) Laparoscopic management of ureteral endometriosis: the Stanford University hospital experience with 96 consecutive cases. J Urol 182:2748–2752CrossRefPubMed
15.
go back to reference Mohr C, Nezhat FR, Nezhat CH, Seidman DS, Nezhat CR (2005) Fertility considerations in laparoscopic treatment of infiltrative bowel endometriosis. JSLS 9:16–24PubMedPubMedCentral Mohr C, Nezhat FR, Nezhat CH, Seidman DS, Nezhat CR (2005) Fertility considerations in laparoscopic treatment of infiltrative bowel endometriosis. JSLS 9:16–24PubMedPubMedCentral
16.
go back to reference Rausei S, Sambucci D, Spampatti S, Cassinotti E, Dionigi G, David G, Ghezzi F, Uccella S, Boni L (2015) Laparoscopic treatment of deep infiltrating endometriosis: results of the combined laparoscopic gynecologic and colorectal surgery. Surg Endosc 29:2904–2909CrossRefPubMed Rausei S, Sambucci D, Spampatti S, Cassinotti E, Dionigi G, David G, Ghezzi F, Uccella S, Boni L (2015) Laparoscopic treatment of deep infiltrating endometriosis: results of the combined laparoscopic gynecologic and colorectal surgery. Surg Endosc 29:2904–2909CrossRefPubMed
17.
go back to reference Uccella S, Cromi A, Casarin J, Bogani G, Pinelli C, Serati M, Ghezzi F (2014) Laparoscopy for ureteral endometriosis: surgical details, long-term follow-up, and fertility outcomes. Fertil Steril 102(160–166):e2PubMed Uccella S, Cromi A, Casarin J, Bogani G, Pinelli C, Serati M, Ghezzi F (2014) Laparoscopy for ureteral endometriosis: surgical details, long-term follow-up, and fertility outcomes. Fertil Steril 102(160–166):e2PubMed
18.
go back to reference Fedele L, Bianchi S, Zanconato G, Berlanda N, Borruto F, Frontino G (2005) Tailoring radicality in demolitive surgery for deeply infiltrating endometriosis. Am J Obstet Gynecol 193:114–117CrossRefPubMed Fedele L, Bianchi S, Zanconato G, Berlanda N, Borruto F, Frontino G (2005) Tailoring radicality in demolitive surgery for deeply infiltrating endometriosis. Am J Obstet Gynecol 193:114–117CrossRefPubMed
19.
go back to reference Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F (1991) Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost 17 Suppl 3:304–312PubMed Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F (1991) Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost 17 Suppl 3:304–312PubMed
20.
go back to reference Ceccaroni M, Clarizia R, Bruni F, D’Urso E, Gagliardi ML, Roviglione G, Minelli L, Ruffo G (2012) Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single-center, prospective, clinical trial. Surg Endosc 26:2029–2045CrossRefPubMed Ceccaroni M, Clarizia R, Bruni F, D’Urso E, Gagliardi ML, Roviglione G, Minelli L, Ruffo G (2012) Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single-center, prospective, clinical trial. Surg Endosc 26:2029–2045CrossRefPubMed
21.
go back to reference Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMedPubMedCentral
22.
go back to reference Ghezzi F, Cromi A, Siesto G, Boni L, Uccella S, Bergamini V, Bolis P (2008) Needlescopic hysterectomy: incorporation of 3-mm instruments in laparoscopic hysterectomy. J Minim Invasive Gynecol 22:2153–2157 Ghezzi F, Cromi A, Siesto G, Boni L, Uccella S, Bergamini V, Bolis P (2008) Needlescopic hysterectomy: incorporation of 3-mm instruments in laparoscopic hysterectomy. J Minim Invasive Gynecol 22:2153–2157
23.
go back to reference Uccella S, Cromi A, Casarin J, Bogani G, Serati M, Gisone B, Pinelli C, Fasola M, Ghezzi F (2015) Minilaparoscopic versus standard laparoscopic hysterectomy for uteri ≥16 weeks of gestation: surgical outcomes, postoperative quality of life, and cosmesis. J Laparoendosc Adv Surg Tech A 25(5):386–391CrossRefPubMed Uccella S, Cromi A, Casarin J, Bogani G, Serati M, Gisone B, Pinelli C, Fasola M, Ghezzi F (2015) Minilaparoscopic versus standard laparoscopic hysterectomy for uteri ≥16 weeks of gestation: surgical outcomes, postoperative quality of life, and cosmesis. J Laparoendosc Adv Surg Tech A 25(5):386–391CrossRefPubMed
24.
go back to reference Uccella S, Ceccaroni M, Cromi A, Malzoni M, Berretta R, De Iaco P, Roviglione G, Bogani G, Minelli L, Ghezzi F (2012) Vaginal cuff dehiscence in a series of 12,398 hysterectomies: effect of different types of colpotomy and vaginal closure. Obstet Gynecol 120:516–523CrossRefPubMed Uccella S, Ceccaroni M, Cromi A, Malzoni M, Berretta R, De Iaco P, Roviglione G, Bogani G, Minelli L, Ghezzi F (2012) Vaginal cuff dehiscence in a series of 12,398 hysterectomies: effect of different types of colpotomy and vaginal closure. Obstet Gynecol 120:516–523CrossRefPubMed
25.
go back to reference Magrina JF, Espada M, Kho RM, Cetta R, Chang YH, Magtibay PM (2015) Surgical excision of advanced endometriosis: perioperative outcomes and impacting factors. J Minim Invasive Gynecol 22:944–950CrossRefPubMed Magrina JF, Espada M, Kho RM, Cetta R, Chang YH, Magtibay PM (2015) Surgical excision of advanced endometriosis: perioperative outcomes and impacting factors. J Minim Invasive Gynecol 22:944–950CrossRefPubMed
26.
go back to reference Afors K, Murtada R, Centini G, Fernandes R, Meza C, Castellano J, Wattiez A (2014) Employing laparoscopic surgery for endometriosis. Womens Health (Lond Engl) 10:431–443. doi:10.2217/whe.14.28 CrossRef Afors K, Murtada R, Centini G, Fernandes R, Meza C, Castellano J, Wattiez A (2014) Employing laparoscopic surgery for endometriosis. Womens Health (Lond Engl) 10:431–443. doi:10.​2217/​whe.​14.​28 CrossRef
27.
go back to reference Ceccaroni M, Clarizia R, Roviglione G, Ruffo G (2013) Neuro-anatomy of the posterior parametrium and surgical considerations for a nerve-sparing approach in radical pelvic surgery. Surg Endosc 27:4386–4394CrossRefPubMed Ceccaroni M, Clarizia R, Roviglione G, Ruffo G (2013) Neuro-anatomy of the posterior parametrium and surgical considerations for a nerve-sparing approach in radical pelvic surgery. Surg Endosc 27:4386–4394CrossRefPubMed
28.
go back to reference Uccella S, Cromi A, Bogani G, Casarin J, Formenti G, Ghezzi F (2013) Systematic implementation of laparoscopic hysterectomy independent of uterus size: clinical effect. J Minim Invasive Gynecol 20:505–516CrossRefPubMed Uccella S, Cromi A, Bogani G, Casarin J, Formenti G, Ghezzi F (2013) Systematic implementation of laparoscopic hysterectomy independent of uterus size: clinical effect. J Minim Invasive Gynecol 20:505–516CrossRefPubMed
29.
go back to reference Garry R, Fountain J, Mason S, Hawe J, Napp V, Abbott J, Clayton R, Phillips G, Whittaker M, Lilford R, Bridgman S, Brown J (2004) The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy. BMJ 328(7432):129CrossRefPubMedPubMedCentral Garry R, Fountain J, Mason S, Hawe J, Napp V, Abbott J, Clayton R, Phillips G, Whittaker M, Lilford R, Bridgman S, Brown J (2004) The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy. BMJ 328(7432):129CrossRefPubMedPubMedCentral
30.
go back to reference Nieboer TE, Johnson N, Lethaby A, Tavender E, Curr E, Garry R, van Voorst S, Mol BW, Kluivers KB (2009) Surgical approach to hysterectomy for benign gynaecological disease. Cochrane Database Syst Rev 3:CD003677. doi:10.1002/14651858.CD003677.pub4 PubMed Nieboer TE, Johnson N, Lethaby A, Tavender E, Curr E, Garry R, van Voorst S, Mol BW, Kluivers KB (2009) Surgical approach to hysterectomy for benign gynaecological disease. Cochrane Database Syst Rev 3:CD003677. doi:10.​1002/​14651858.​CD003677.​pub4 PubMed
Metadata
Title
Impact of endometriosis on surgical outcomes and complications of total laparoscopic hysterectomy
Authors
Stefano Uccella
Nicola Marconi
Jvan Casarin
Marcello Ceccaroni
Luigi Boni
Davide Sturla
Maurizio Serati
Simona Carollo
Carolina Podesta’ Alluvion
Fabio Ghezzi
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4115-9

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