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01-05-2016 | Review

Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner

Authors: Antonio Simone Laganà, Onofrio Triolo, Francesca Maria Salmeri, Roberta Granese, Vittorio Italo Palmara, Helena Ban Frangež, Eda Vrtčnik Bokal, Vincenza Sofo

Published in: Archives of Gynecology and Obstetrics | Issue 5/2016

Abstract

Purpose

Invariant Natural Killer T cells (iNKT) are a specialized subset of T cells that use their T cell receptor to recognize self and foreign lipids presented by CD1d as cognate antigens. iNKT have been shown to have either protective or harmful roles in many pathological states, including microbial infection, autoimmune disease, allergic disease and cancer. Accumulating evidence seems to suggest that this unique T cell subset combines both classically innate and adaptive immunologic characteristic. Considering these recent data, the aim of work was to review the current knowledge about iNKT in eutopic and ectopic endometrium.

Methods

Narrative overview, synthesizing the findings of literature retrieved from searches of computerized databases.

Results

Currently, the immune paradigm of reproduction is gradually changing shape: recent data confirmed that cytokine milieu influences the development and plasticity of different subtype of mononuclear cells, and in turn it can be influenced by the cytokine production of the latter. Among the different NKT cell populations, the recently characterized iNKT seems to share actions typical both of innate and adaptive immunity, being capable of secreting Th1 as well as Th2 cytokine pattern. Moreover, several subtypes of iNKT were identified, who partially express the same master transcription factors of the corresponding T cells counterpart.

Conclusions

Although the data about iNKT’s actions in eutopic and ectopic endometrium are still scarce, it is possible to hypothesize that future investigation can shed light on this point, thus allowing a better knowledge about the regulation of these two microenvironments.

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Title: Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner
Authors: Antonio Simone Laganà
Onofrio Triolo
Francesca Maria Salmeri
Roberta Granese
Vittorio Italo Palmara
Helena Ban Frangež
Eda Vrtčnik Bokal
Vincenza Sofo
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-4004-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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