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Archives of Gynecology and Obstetrics

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01-01-2016 | Review

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Authors: Chaoqing Tian, Chengwen Hu, Xiujie He, Meng Zhu, Fengyun Qin, Yue Liu, Chuanlai Hu

Published in: Archives of Gynecology and Obstetrics | Issue 1/2016

Abstract

Purpose

This meta-analysis aimed to estimate the relation between excessive gestational weight gain and macrosomia.

Methods

We performed a meta-analysis by searching PubMed, EMBASE and the Cochrane library for English-language literature from inception to 1 October 2014. Studies assessing the relationship between excessive gestational weight gain and macrosomia were included. Characteristics including study design, country, sample size, definition of macrosomia, adjusted odds ratios, CIs and adjustment factors were extracted independently by two reviewers. Summary odds ratios were calculated by using a random-effects model meta-analysis.

Results

15 relevant articles were eligible for the meta-analysis. Incorporated by random-effect model before the heterogeneity tests, the value of OR was 2.35 (95 % CI: 1.95, 2.85). Stratified analysis showed no differences regarding different study design, definition of macrosomia and location of study. There was no indication of a publication bias either from the result of Egger’s test (P = 0.572) or Begg’s test (P = 0.572).

Conclusions

Our meta-analysis indicated that excessive gestational weight gain might increase the risk of macrosomia.

Tsai YL, Chong KM et al (2013) Following the 2009 American Institute of Medicine recommendations for normal body mass index and overweight women led to an increased risk of fetal macrosomia among Taiwanese women. Taiwan J Obstet Gynecol 52(3):341–346PubMedCrossRef

Morikawa M, Cho K et al (2013) Fetal macrosomia in Japanese women. J Obstet Gynaecol Res 39(5):960–965PubMedCrossRef

Ye J, Zhang L et al (2014) Searching for the definition of macrosomia through an outcome-based approach. PLoS One 9(6):e100192PubMedPubMedCentralCrossRef

Lim JH et al (2002) Delivery of macrosomic babies: management and outcomes of 330 cases. J Obstet Gynaecol 22(4):370–374PubMedCrossRef

Henriksen T (2006) Nutrition and pregnancy outcome. Nutr Rev 64(5 Pt 2):S19–S23 (discussion S72–91) PubMedCrossRef

Harder T et al (2007) Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am J Epidemiol 165(8):849–857PubMedCrossRef

Mehta SH, Kruger M, Sokol RJ (2011) Being too large for gestational age precedes childhood obesity in African Americans. Am J Obstet Gynecol 204(3):265-e1–e5CrossRef

Tie HT, Xia YY et al (2014) Risk of childhood overweight or obesity associated with excessive weight gain during pregnancy: a meta-analysis. Arch Gynecol Obstet 289(2):247–257PubMedCrossRef

Jolly MC et al (2003) Risk factors for macrosomia and its clinical consequences: a study of 350,311 pregnancies. Eur J Obstet Gynecol Reprod Biol 111(1):9–14PubMedCrossRef

10.

Boulet SL, Salihu HM, Alexander GR (2004) Mode of delivery and birth outcomes of macrosomic infants. J Obstet Gynaecol 24(6):622–629PubMedCrossRef

11.

Stotland NE et al (2004) Risk factors and obstetric complications associated with macrosomia. Int J Gynaecol Obstet 87(3):220–226PubMedCrossRef

12.

Berard J et al (1998) Fetal macrosomia: risk factors and outcome. A study of the outcome concerning 100 cases >4500 g. Eur J Obstet Gynecol Reprod Biol 77(1):51–59PubMedCrossRef

13.

Rasmussen KM, Yaktine AL (eds) (2009) Weight gain during pregnancy: reexamining the guidelines. Washington

14.

Skouteris H, Hartley-Clark L, McCabe M et al (2010) Preventing excessive gestational weight gain: a systematic review of interventions. Obes Rev 11(11):757–768PubMedCrossRef

15.

Chu SY, Callaghan WM et al (2009) Gestational weight gain by body mass index among US women delivering live births, 2004–2005 fueling future obesity. Am J Obstet Gynecol 200(3):271-e1-e7CrossRef

16.

Stotland NE, Cheng YW et al (2006) Gestational weight gain and adverse neonatal outcome among term infants. Obstet Gynecol 108(3 Pt 1):635–643PubMedCrossRef

17.

Li S et al (2013) Central adiposity and other anthropometric factors in relation to risk of macrosomia in an African American population. Obesity (Silver Spring) 21(1):178–184CrossRef

18.

Langford A et al (2011) Does gestational weight gain affect the risk of adverse maternal and infant outcomes in overweight women? Matern Child Health J 15(7):860–865PubMedCrossRef

19.

Tsai YL, Chong KM, Seow KM (2013) Following the 2009 American Institute of Medicine recommendations for normal body mass index and overweight women led to an increased risk of fetal macrosomia among Taiwanese women. Taiwan J Obstet Gynecol 52(3):341–346PubMedCrossRef

20.

Cogswell ME et al (1995) Gestational weight gain among average-weight and overweight women–what is excessive? Am J Obstet Gynecol 172(2 Pt 1):705–712PubMedCrossRef

21.

Dietz PM, Callaghan WM, Sharma AJ (2009) High pregnancy weight gain and risk of excessive fetal growth. Am J Obstet Gynecol 201(1):51-e1–e6

22.

Clausen T et al (2005) Maternal anthropometric and metabolic factors in the first half of pregnancy and risk of neonatal macrosomia in term pregnancies. A prospective study. Eur J Endocrinol 153(6):887–894PubMedCrossRef

23.

Vesco KK et al (2011) Newborn size among obese women with weight gain outside the 2009 Institute of Medicine recommendation. Obstet Gynecol 117(4):812–818PubMedCrossRef

24.

Frederick IO et al (2008) Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight. Matern Child Health J 12(5):557–567PubMedCrossRef

25.

Hedderson MM et al (2006) Pregnancy weight gain and risk of neonatal complications: macrosomia, hypoglycemia, and hyperbilirubinemia. Obstet Gynecol 108(5):1153–1161PubMedCrossRef

26.

Liu Y et al (2012) Prepregnancy body mass index and gestational weight gain with the outcome of pregnancy: a 13-year study of 292,568 cases in China. Arch Gynecol Obstet 286(4):905–911PubMedCrossRef

27.

Bergmann RL et al (2003) Secular trends in neonatal macrosomia in Berlin: influences of potential determinants. Paediatr Perinat Epidemiol 17(3):244–249PubMedCrossRef

28.

Alberico S et al (2014) The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy Childbirth 14:23PubMedPubMedCentralCrossRef

29.

Park JH et al (2011) Association between pre-pregnancy body mass index and socioeconomic status and impact on pregnancy outcomes in Korea. J Obstet Gynaecol Res 37(2):138–145PubMedCrossRef

30.

Voldner N et al (2008) Modifiable determinants of fetal macrosomia: role of lifestyle-related factors. Acta Obstet Gynecol Scand 87(4):423–429PubMedCrossRef

31.

Kabali C, Werler MM (2007) Pre-pregnant body mass index, weight gain and the risk of delivering large babies among non-diabetic mothers. Int J Gynaecol Obstet 97(2):100–104PubMedPubMedCentralCrossRef

32.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558PubMedCrossRef

33.

Higgins JP et al (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560PubMedPubMedCentralCrossRef

34.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188PubMedCrossRef

35.

Woolf B (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19(4):251–253PubMedCrossRef

36.

Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101PubMedCrossRef

37.

Egger M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634PubMedPubMedCentralCrossRef

38.

Henriksen T (2008) The macrosomic fetus: a challenge in current obstetrics. Acta Obstet Gynecol Scand 87(2):134–145PubMedCrossRef

39.

Segregur J et al (2009) Fetal macrosomia in pregnant women with gestational diabetes. Coll Antropol 33(4):1121–1127PubMed

40.

Linne Y et al (2004) Long-term weight development in women: a 15-year follow-up of the effects of pregnancy. Obes Res 12(7):1166–1178PubMedCrossRef

41.

Walker LO, Sterling BS, Timmerman GM (2005) Retention of pregnancy-related weight in the early postpartum period: implications for women’s health services. J Obstet Gynecol Neonatal Nurs 34(4):418–427PubMedCrossRef

42.

Di Carlo C, Iannotti G et al (2014) The role of a personalized dietary intervention in managing gestational weight gain: a prospective, controlled study in a low-risk antenatal population. Arch Gynecol Obstet 289(4):765–770PubMedCrossRef

43.

Skouteris H, Hartley-Clark L et al (2010) Preventing excessive gestational weight gain: a systematic review of interventions. Obes Rev 11(11):757–768PubMedCrossRef

Title: Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis
Authors: Chaoqing Tian
Chengwen Hu
Xiujie He
Meng Zhu
Fengyun Qin
Yue Liu
Chuanlai Hu
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3825-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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