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Archives of Gynecology and Obstetrics

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01-09-2015 | Review

Dienogest in the treatment of endometriosis: systematic review

Authors: Marina de Paula Andres, Livia Alves Lopes, Edmund Chada Baracat, Sergio Podgaec

Published in: Archives of Gynecology and Obstetrics | Issue 3/2015

Abstract

Purpose

Endometriosis is a prevalent disease that affects 5–15 % of women of reproductive age. The aim of this study is to assess the effect of dienogest in the treatment of endometriosis.

Methods

The search was applied to electronic databases PubMed, Cochrane, EMBASE and Lilacs until September 2014, in a public tertiary hospital. We performed a systematic literature search of randomized trials comparing dienogest to other medical therapies in the treatment of endometriosis, as well as their references list, using the keywords “dienogest” and “endometriosis” by two independent authors. The data extraction were performed by two authors using predefined data fields. Nine randomized trials were included. Dienogest 2 mg/day was superior to placebo in reducing pelvic pain (27.4 versus 15.1 mm, P < 0.0001), with similar results to buserelin, leuprorelin, leuprolide acetate and triptorelin, in controlling symptoms associated with endometriosis. Dienogest 2 mg/day was effective in reducing endometriotic lesions (11.4 ± 1.71–3.6 ± 0.95, P < 0.001). The extended therapy with dienogest 2 mg/day also showed an improvement in pelvic pain after 24–52 weeks (−22.5 ± 32.1 and −28.4 ± 29.9 mm, respectively) with tolerable side effects.

Conclusion

Dienogest should be considered as an alternative for controlling symptoms related to endometriosis. Nevertheless, in this systematic review, no studies were found comparing dienogest with first-line therapy, such as progestins and estrogen–progestogen combinations, which are proved to be effective in the treatment of endometriosis, are less expensive, and also can be used for contraception.

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Title: Dienogest in the treatment of endometriosis: systematic review
Authors: Marina de Paula Andres
Livia Alves Lopes
Edmund Chada Baracat
Sergio Podgaec
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3681-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dienogest in the treatment of endometriosis: systematic review

Abstract

Purpose

Methods

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Conclusion

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