Top

Published in:

01-07-2015 | Maternal-Fetal Medicine

Serum levels of neopterin in gestational diabetes mellitus: the relationship with Apgar scores

Authors: Suleyman Hilmi Ipekci, Ayse Gul Kebapcilar, Setenay Arzu Yilmaz, Tolgay Tuyan Ilhan, Aybike Tazegul Pekin, Sedat Abusoglu, Ali Unlu, Ali Annagur, Cetin Celik

Published in: Archives of Gynecology and Obstetrics | Issue 1/2015

Abstract

Purpose

This study was designed to evaluate neopterin levels and low Apgar scores in pregnancies with gestational diabetes mellitus (GDM) vs. normal control pregnancies.

Methods

We carried out a cross-sectional study by enrolling 81 pregnant women with GDM and 38 pregnant women without GDM.

Results

Maternal and cord blood neopterin levels were higher in women with GDM. There was a significant positive association between fasting blood glucose levels and maternal serum neopterin levels. The results of 50-g oral glucose challenge tests revealed a correlation between maternal and cord neopterin levels. Pregnancies complicated by GDM exhibited lower fetal Apgar scores than those of control subjects. The levels of cord blood neopterin were inversely correlated with an fetal Apgar score of 1 min in patients with GDM.

Conclusions

Patients with GDM had higher maternal and cord blood neopterin levels, and the cord blood neopterin levels are inversely associated with lower Apgar scores in women with GDM. The neopterin levels might be potential predictors of low fetal Apgar scores in women with GDM.

American College of Obstetricians and Gynecologists Committee on Practice Bulletins–Obstetrics (2001) ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes. Obstet Gynecol 98:525–538

Hanna FW, Peters JR, Harlow J, Jones PW (2008) Gestational diabetes screening and glycaemic management; national survey on behalf of the Association of British Clinical Diabetologists. QJM 101:777–784. doi:10.1093/qjmed/hcn069 CrossRefPubMed

Bennett WA, Lagoo-Deenadayalan S, Brackin MN, Hale E, Cowan BD (1996) Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcriptionpolymerase chain reaction technique. Am J Reprod Immunol 36:285–294CrossRefPubMed

Darmochwal-Kolarz D, Leszczynska-Gorzelak B, Rolinski J, Oleszczuk J (1999) T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 86:165–170CrossRefPubMed

Peltier MR (2003) Immunology of term and preterm labor. Reprod Biol Endocrinol 1:122CrossRefPubMedCentralPubMed

Yu F, Xue YM, Li CZ, Shen J, Gao F, Yu YH, Fu XJ (2007) Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational diabetes mellitus. Nan Fang Yi Ke Da Xue Xue Bao 27:799–801 (Abstract)PubMed

Altinova AE, Toruner F, Bozkurt N, Bukan N, Karakoc A, Yetkin I, Ayvaz G, Cakir N, Arslan M (2007) Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. Gynecol Endocrinol 23:161–165CrossRefPubMed

Weiss MF, Rodby RA, Justice AC, Hricik DE (1998) Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group. Kidney Int 54:193–202PubMed

Vengen IT, Dale AC, Wiseth R, Midthjell K, Videm V (2009) Neopterin predicts the risk for fatal ischemic heart disease in type 2 diabetes mellitus: long-term follow-up of the HUNT 1 study. Atherosclerosis 207:239–244. doi:10.1016/j.atherosclerosis.2009.04.003 CrossRefPubMed

10.

Grammer TB, Fuchs D, Boehm BO, Winkelmann BR, Maerz W (2009) Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography in the Ludwigshafen Risk and Cardiovascular Health study. Clin Chem 55:1135–1146. doi:10.1373/clinchem.2008.118844 CrossRefPubMed

11.

Brown GM (1971) The biosynthesis of pteridines. Adv Enzymol Relat Areas Mol Biol 35:35–77PubMed

12.

Fuchs D, Weiss G, Reibnegger G, Wachter H (1992) The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci 1992 29:307–341CrossRef

13.

Fuchs D, Avanzas P, Arroyo-Espliguero R, Jenny M, Consuegra-Sanchez L, Kaski JC (2009) The role of neopterin in atherogenesis and cardiovascular risk assessment. Curr Med Chem 16:4644–4653CrossRefPubMed

14.

Ainbender E, Cabatu EE, Guzman DM, Sweet AY (1982) Serum C-reactive protein and problems of newborn infants. J Pediatr 101:438–440CrossRefPubMed

15.

Dyck RF, Bingham W, Tan L, Rogers SL (1984) Serum levels of C-reactive protein in neonatal respiratory distress syndrome. Clin Pediatr (Phila) 23:381–383CrossRef

16.

Mwanyumba F, Inion I, Gaillard P, Mandaliya K, Praet M, Temmerman M (2003) Placental inflammation and perinatal outcome. Eur J Obstet Gynecol Reprod Biol 108:164–170CrossRefPubMed

17.

Johns K, Olynik C, Mase R, Kreisman S, Tildesley H (2006) Gestational diabetes mellitus outcome in 394 patients. J Obstet Gynaecol Can 28:122–127PubMed

18.

Sugaya A, Sugiyama T, Nagata M, Toyoda N (2000) Comparison of the validity of the criteria for gestational diabetes mellitus by WHO and by the Japan Society of Obstetrics and Gynecology by the outcomes of pregnancy. Diabetes Res Clin Pract 50:57–63CrossRefPubMed

19.

Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26(Suppl 1):S5–20

20.

Metzger BE, Buchanan TA, Coustan, de Leiva A, Dunger DB, Hadden, Hod M, Kitzmiller JL, Kjos SL, Oats JN, Pettitt DJ, Sacks DA, Zoupas C (2007) Summary and recommendations of the Fifth International Workshop Conference on gestational diabetes mellitus. Diabetes Care 30(Suppl 2):S251–S260. doi:10.2337/dc07-s225 CrossRefPubMed

21.

Alrashed M, Abougoush M, Akgul EO, Erbil MK (2002) Detection method of serum and urine neopterin levels by high performance liquid chromatography and clinical applications. Gulhane MJ 44:273–277 (Article in Turkish)

22.

Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, Kahn SE (2006) Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care 29:2078–2083CrossRefPubMed

23.

Räsänen J, Kirkinen P (1987) Growth and function of human foetal heart in normal, hypertensive and diabetic pregnancy. Acta Obstet Gynecol Scand 66:349–353CrossRefPubMed

24.

Chu C, Gui YH, Ren YY, Shi LY (2012) The impacts of maternal gestational diabetes mellitus (GDM) on fetal hearts. Biomed Environ Sci 25:15–22. doi:10.3967/0895-3988.2012.01.003 PubMed

25.

Richardson AC, Carpenter MW (2007) Inflammatory mediators in gestational diabetes mellitus. Obstet Gynecol Clin North Am 34:213–224CrossRefPubMed

26.

Lasselin J, Layé S, Dexpert S, Aubert A, Gonzalez C, Gin H, Capuron L (2012) Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes. Brain Behav Immun 26:1211–1219. doi:10.1016/j.bbi.2012.03.003 CrossRefPubMed

27.

Baris N, Erdogan M, Sezer E, Saygili F, Mert Ozgonul A, Turgan N, Ersoz B (2009) Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria. Acta Diabetol 46:309–316. doi:10.1007/s00592-008-0089-9 CrossRefPubMed

28.

Lhee HY, Kim H, Joo KJ, Jung SS, Lee KB (2006) The clinical significance of serum and urinary neopterin levels in several renal diseases. J Korean Med Sci 21:678–682CrossRefPubMedCentralPubMed

29.

Gitto E, Pellegrino S, D’Arrigo S, Barberi I, Reiter RJ (2009) Oxidative stress in resuscitation and in ventilation of newborns. Eur Respir J 34:1461–1469. doi:10.1183/09031936.00032809 CrossRefPubMed

30.

Eklind S, Mallard C, Arvidsson P, Hagberg H (2005) Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain. Pediatr Res 58:112–116CrossRefPubMed

31.

Ben-Hur T, Ben-Menachem O, Furer V, Einstein O, Mizrachi-Kol R, Grigoriadis N (2003) Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol Cell Neurosci 24:623–631CrossRefPubMed

32.

Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H (1988) Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today 9:150–155CrossRefPubMed

Title: Serum levels of neopterin in gestational diabetes mellitus: the relationship with Apgar scores
Authors: Suleyman Hilmi Ipekci
Ayse Gul Kebapcilar
Setenay Arzu Yilmaz
Tolgay Tuyan Ilhan
Aybike Tazegul Pekin
Sedat Abusoglu
Ali Unlu
Ali Annagur
Cetin Celik
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3615-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum levels of neopterin in gestational diabetes mellitus: the relationship with Apgar scores

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2015

Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO

New associate Editor Prof. Dr. med. Christina Fotopoulou

Clinical implications of first and multiple locoregional breast cancer recurrences

Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia

Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Multidisciplinary OBGYN morbidity and mortality conference