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01-01-2013 | Maternal-Fetal Medicine

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Authors: Takashi Yamada, Mamoru Morikawa, Takahiro Yamada, Reiko Kishi, Kazuo Sengoku, Toshiaki Endo, Tsuyoshi Saito, Kazutoshi Cho, Hisanori Minakami

Published in: Archives of Gynecology and Obstetrics | Issue 1/2013

Abstract

Objectives

To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).

Study design

A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.

Results

The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.

Conclusion

Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.

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Title: First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
Authors: Takashi Yamada
Mamoru Morikawa
Takahiro Yamada
Reiko Kishi
Kazuo Sengoku
Toshiaki Endo
Tsuyoshi Saito
Kazutoshi Cho
Hisanori Minakami
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2501-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Abstract

Objectives

Study design

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Study design

Results

Conclusion

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