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Published in: Archives of Gynecology and Obstetrics 5/2012

01-11-2012 | Gynecologic Oncology

Coexisting ovarian malignancy in patients with clinical stage I endometrial carcinoma

Authors: Ozgur Akbayır, Oguzhan Kuru, Pınar Goksedef, Ceyhun Numanoglu, Aytul Corbacıoglu, Ahmet Cetin

Published in: Archives of Gynecology and Obstetrics | Issue 5/2012

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Abstract

Aim

To evaluate the feasibility of ovarian preservation at the time of operation in patients with clinical stage I endometrial carcinoma.

Materials and methods

The data of 499 consecutive patients with clinical stage 1 endometrial cancer operated between January 2001 and December 2011 were retrospectively reviewed. Clinical and pathologic information and the intraoperative inspection findings of ovaries were evaluated to find the factors associated with the coexisting ovarian malignancy.

Results

The mean age of patients was 56.8 ± 9.8 years. Coexisting ovarian tumors were detected in 38 patients (7.6 %), and 28 (5.6 %) of them were malignant (12 metastatic and 16 synchronous primaries). Most of the patients were postmenopausal (n = 371, 74.3 %) and 60 (12 %) of the patients were at the age of 45 years or less. Coexisting malignancy was detected in 9 % (n = 11) of the premenopausal patients and in 5 % (n = 3) of the patients aged 45 years or less. Multivariate analysis revealed that serosal invasion, tubal involvement, and positive abdominal cytology were independent risk factors for coexisting ovarian malignancy. The sensitivity, specificity, positive predictive value and negative predictive value of the intraoperative examination for the diagnosis of benign/normal ovary was 99.6, 78.8, 98.5 and 92.9 %, respectively.

Conclusion

The incidence of coexisting ovarian malignancy in clinical stage I endometrial carcinoma is low. Although occult metastasis cannot be excluded at all, careful intraoperative inspection of ovaries seems valuable for the prediction of co-existing ovarian malignancy.
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Metadata
Title
Coexisting ovarian malignancy in patients with clinical stage I endometrial carcinoma
Authors
Ozgur Akbayır
Oguzhan Kuru
Pınar Goksedef
Ceyhun Numanoglu
Aytul Corbacıoglu
Ahmet Cetin
Publication date
01-11-2012
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 5/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-012-2402-7

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