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Published in: Archives of Gynecology and Obstetrics 1/2012

01-07-2012 | Maternal-Fetal Medicine

Fetal growth restriction: current knowledge to the general Obs/Gyn

Authors: Luciano Marcondes Machado Nardozza, Edward Araujo Júnior, Maurício Mendes Barbosa, Ana Carolina Rabachini Caetano, Desireé Ji Re Lee, Antonio Fernandes Moron

Published in: Archives of Gynecology and Obstetrics | Issue 1/2012

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Abstract

Background

Fetal growth restriction (FGR) is a condition that affects 5–10 % of gestations, and it is the second primary cause of perinatal mortality. In this review the most recent knowledge about FGR is presented focusing on its concept, etiology, classification, diagnosis, management, and prognosis.

Methods

Searches were conducted in Pubmed, Embase and Lilacs database using the term fetal growth restriction.

Results

FGR is classified as type I (symmetric), manifested early, in which there is a proportional reduction of all fetal parts, generally associated with chromosome abnormalities; type II (asymmetric), with late onset, in which there is a more accentuated reduction of the abdomen, generally related to placental insufficiency; and type III (mixed), with early manifestation, resulting from infections or exposure to toxic agents. Diagnosis may be clinical, although ultrasound associated with arterial and venous Doppler is essential for diagnosis and follow-up. Currently there is no treatment capable of controlling FGR, and the moment of interruption of pregnancy is of vital importance in order to protect maternal and fetal interests.

Conclusion

Early diagnosis of FGR is very important, because it permits the etiological identification and adequate monitoring of fetal vitality, minimizing the risks related to prematurity and intrauterine hypoxia.
Literature
1.
go back to reference Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B (2004) Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand 83:801–807PubMed Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B (2004) Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand 83:801–807PubMed
2.
go back to reference Barker DJ, Gluckman PD, Godfrey KM (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938–941PubMedCrossRef Barker DJ, Gluckman PD, Godfrey KM (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938–941PubMedCrossRef
3.
go back to reference Hepburn M, Rosenberg K (1986) An audit of the detection and management of small-for-gestational age babies. Br J Obstet Gynaecol 93:212–216PubMedCrossRef Hepburn M, Rosenberg K (1986) An audit of the detection and management of small-for-gestational age babies. Br J Obstet Gynaecol 93:212–216PubMedCrossRef
4.
go back to reference Manning FA (1995) Intrauterine growth retardation. In: Fetal medicine. Principal and practice. Appleton & Lange, Norwalk Manning FA (1995) Intrauterine growth retardation. In: Fetal medicine. Principal and practice. Appleton & Lange, Norwalk
5.
6.
go back to reference Lin CC, Santolaya-Forgas J (1998) Current concepts of fetal growth restriction: part I. Causes, classification, and pathophysiology. Obstet Gynecol 92:1044–1055PubMedCrossRef Lin CC, Santolaya-Forgas J (1998) Current concepts of fetal growth restriction: part I. Causes, classification, and pathophysiology. Obstet Gynecol 92:1044–1055PubMedCrossRef
7.
go back to reference Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E et al (2003) IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 349:2211–2222PubMedCrossRef Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E et al (2003) IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 349:2211–2222PubMedCrossRef
8.
go back to reference Neerhof MG (1995) Causes of intrauterine growth restriction. Clin Perinatol 22:375–385PubMed Neerhof MG (1995) Causes of intrauterine growth restriction. Clin Perinatol 22:375–385PubMed
9.
go back to reference Blickstein I (2004) Is it normal for multiples to be smaller than singletons? Best Pract Res Clin Obstet Gynaecol 18:613–623PubMedCrossRef Blickstein I (2004) Is it normal for multiples to be smaller than singletons? Best Pract Res Clin Obstet Gynaecol 18:613–623PubMedCrossRef
10.
go back to reference Galan HL, Rigano S, Radaelli T, Cetin I, Bozzo M, Chyu J et al (2001) Reduction subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado. Am J Obstet Gynecol 185:839–844PubMedCrossRef Galan HL, Rigano S, Radaelli T, Cetin I, Bozzo M, Chyu J et al (2001) Reduction subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado. Am J Obstet Gynecol 185:839–844PubMedCrossRef
11.
go back to reference Infant-Rivard C, Rivard GE, Yotov WV, Génin E, Guiguet M, Weinberg C et al (2002) Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 347:19–25CrossRef Infant-Rivard C, Rivard GE, Yotov WV, Génin E, Guiguet M, Weinberg C et al (2002) Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 347:19–25CrossRef
12.
go back to reference McCowan LM, Craige S, Taylor RS, Ward C, McLintock C, North RA (2003) Inherited thrombophilias are not increased in “idiopathic” small-for-gestational-age pregnancies. Am J Obstet Gynecol 188:981–985PubMedCrossRef McCowan LM, Craige S, Taylor RS, Ward C, McLintock C, North RA (2003) Inherited thrombophilias are not increased in “idiopathic” small-for-gestational-age pregnancies. Am J Obstet Gynecol 188:981–985PubMedCrossRef
13.
go back to reference Nathanielsz PW (1999) The Ducth hunger winter. In: Life in the womb: the origin of health and disease. Promethean press, Ithaca Nathanielsz PW (1999) The Ducth hunger winter. In: Life in the womb: the origin of health and disease. Promethean press, Ithaca
14.
go back to reference Lieberman E, Gremy I, Lang JM, Cohen AP (1994) Low birthweight at term and timing of fetal exposure to maternal smoking. Am J Public Health 84:1127–1131PubMedCrossRef Lieberman E, Gremy I, Lang JM, Cohen AP (1994) Low birthweight at term and timing of fetal exposure to maternal smoking. Am J Public Health 84:1127–1131PubMedCrossRef
15.
go back to reference Khong TY, Pearce JM (1987) The placenta in perinatal pathology. In: Clinical perspectives. Aspen, Rockville, pp 25–45 Khong TY, Pearce JM (1987) The placenta in perinatal pathology. In: Clinical perspectives. Aspen, Rockville, pp 25–45
16.
go back to reference Regnault TL, Galan HL, Parker TA, Anthony RV (2002) Placental development in normal and compromised pregnancies—a review. Placenta 23(Suppl A):S119–S129PubMedCrossRef Regnault TL, Galan HL, Parker TA, Anthony RV (2002) Placental development in normal and compromised pregnancies—a review. Placenta 23(Suppl A):S119–S129PubMedCrossRef
17.
go back to reference Fleisher A, Schulman H, Farmakides G, Bracero L, Grunfeld L, Rochelson B et al (1986) Uterine artery Doppler velocimetry in pregnant women with hypertension. Am J Obstet Gynecol 154:806–813 Fleisher A, Schulman H, Farmakides G, Bracero L, Grunfeld L, Rochelson B et al (1986) Uterine artery Doppler velocimetry in pregnant women with hypertension. Am J Obstet Gynecol 154:806–813
18.
go back to reference Carrera JM, Malafré J, Otero F, Rubio R, Carrera M (1992) Síndrome de mal adaptación circulatória materna: bases etipopatogénicas y terapéuticas. In: Carrera JM (ed) Doppler en obstetricia. Masson-Salvat, Barcelona, pp 335–360 Carrera JM, Malafré J, Otero F, Rubio R, Carrera M (1992) Síndrome de mal adaptación circulatória materna: bases etipopatogénicas y terapéuticas. In: Carrera JM (ed) Doppler en obstetricia. Masson-Salvat, Barcelona, pp 335–360
19.
go back to reference Robertson WB, Brosens I, Pijnenborg R, De Wolf F (1984) The making of placental bed. Eur J Obstet Gynecol Reprod Biol 18:255–266PubMedCrossRef Robertson WB, Brosens I, Pijnenborg R, De Wolf F (1984) The making of placental bed. Eur J Obstet Gynecol Reprod Biol 18:255–266PubMedCrossRef
20.
go back to reference Dashe JS, McIntire DD, Lucas MJ, Leveno KJ (2000) Effects of symmetric and asymmetric fetal growth on pregnancy outcomes. Obstet Gynecol 96:321–327PubMedCrossRef Dashe JS, McIntire DD, Lucas MJ, Leveno KJ (2000) Effects of symmetric and asymmetric fetal growth on pregnancy outcomes. Obstet Gynecol 96:321–327PubMedCrossRef
21.
go back to reference Albaiges G, Missfelder-Lobos H, Parra M, Lees C, Cooper D, Nicolaides KH (2003) Comparison of color Doppler uterine artery indices in a population at high risk for adverse outcome at 24 weeks’ gestation. Ultrasound Obstet Gynecol 21:170–173PubMedCrossRef Albaiges G, Missfelder-Lobos H, Parra M, Lees C, Cooper D, Nicolaides KH (2003) Comparison of color Doppler uterine artery indices in a population at high risk for adverse outcome at 24 weeks’ gestation. Ultrasound Obstet Gynecol 21:170–173PubMedCrossRef
22.
go back to reference North RA, Ferrier C, Long D, Townsend K, Kincaid-Smith P (1994) Uterine artery Doppler flow velocity waveforms in the second trimester for the prediction of pre-eclampsia and fetal growth retardation. Obstet Gynecol 83:378–386PubMed North RA, Ferrier C, Long D, Townsend K, Kincaid-Smith P (1994) Uterine artery Doppler flow velocity waveforms in the second trimester for the prediction of pre-eclampsia and fetal growth retardation. Obstet Gynecol 83:378–386PubMed
23.
go back to reference Papagerghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH (2001) Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18:441–449CrossRef Papagerghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH (2001) Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18:441–449CrossRef
24.
go back to reference Caniggia I, Winter J, Lye SJ, Post M (2000) Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta 21:S25–S30PubMedCrossRef Caniggia I, Winter J, Lye SJ, Post M (2000) Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta 21:S25–S30PubMedCrossRef
25.
go back to reference Melchiorre K, Leslie K, Prefumo F, Bhide A, Thilaganathan B (2009) First-trimester uterine artery Doppler indices in the prediction of small-for-gestational age pregnancy and intrauterine growth restriction. Ultrasound Obstet Gynecol 33:524–529PubMedCrossRef Melchiorre K, Leslie K, Prefumo F, Bhide A, Thilaganathan B (2009) First-trimester uterine artery Doppler indices in the prediction of small-for-gestational age pregnancy and intrauterine growth restriction. Ultrasound Obstet Gynecol 33:524–529PubMedCrossRef
26.
go back to reference Martin AM, Bindra R, Curcio P, Cicero S, Nicolaides KH (2001) Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation. Ultrasound Obstet Gynecol 18:583–586PubMedCrossRef Martin AM, Bindra R, Curcio P, Cicero S, Nicolaides KH (2001) Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation. Ultrasound Obstet Gynecol 18:583–586PubMedCrossRef
27.
go back to reference Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC et al (2009) Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 34:274–282PubMedCrossRef Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC et al (2009) Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 34:274–282PubMedCrossRef
28.
go back to reference Pilalis A, Souka AP, Antsaklis P, Daskalakis G, Papantoniou N, Mesogitis S et al (2007) Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11–14 weeks’ gestation. Ultrasound Obstet Gynecol 29:135–140PubMedCrossRef Pilalis A, Souka AP, Antsaklis P, Daskalakis G, Papantoniou N, Mesogitis S et al (2007) Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11–14 weeks’ gestation. Ultrasound Obstet Gynecol 29:135–140PubMedCrossRef
29.
go back to reference Zhong Y, Tuuli M, Odibo AO (2009) First-trimester assessment of placenta function and the prediction of preeclampsia and intrauterine growth restriction. Prenat Diagn 30:293–308 Zhong Y, Tuuli M, Odibo AO (2009) First-trimester assessment of placenta function and the prediction of preeclampsia and intrauterine growth restriction. Prenat Diagn 30:293–308
30.
go back to reference Merce LT, Barco MJ, Bau S, Kupesic S, Kurjak A (2005) Assessment of placental vascularization by three-dimensional power Doppler “vascular biopsy” in normal pregnancies. Croat Med J 46:765–771PubMed Merce LT, Barco MJ, Bau S, Kupesic S, Kurjak A (2005) Assessment of placental vascularization by three-dimensional power Doppler “vascular biopsy” in normal pregnancies. Croat Med J 46:765–771PubMed
31.
go back to reference Hafner E, Metzenbauer M, Hofinger D, Stonek F, Schuchter K, Waldhör T et al (2006) Comparison between three-dimensional placental volume at 12 weeks and uterine artery impedance/notching at 22 weeks in screening for pregnancy-induced hypertension, pre-eclampsia and fetal growth restriction in a low-risk population. Ultrasound Obstet Gynecol 27:652–657PubMedCrossRef Hafner E, Metzenbauer M, Hofinger D, Stonek F, Schuchter K, Waldhör T et al (2006) Comparison between three-dimensional placental volume at 12 weeks and uterine artery impedance/notching at 22 weeks in screening for pregnancy-induced hypertension, pre-eclampsia and fetal growth restriction in a low-risk population. Ultrasound Obstet Gynecol 27:652–657PubMedCrossRef
32.
go back to reference Odibo AO, Goetzinger KR, Huster KM, Christiansen JK, Odibo L, Tuuli MG (2011) Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes. Placenta 32:230–234PubMedCrossRef Odibo AO, Goetzinger KR, Huster KM, Christiansen JK, Odibo L, Tuuli MG (2011) Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes. Placenta 32:230–234PubMedCrossRef
33.
go back to reference Kennelly MM, Farah N, Turner MJ, Stuart B (2010) Aortic isthmus Doppler velocimetry: role in assessment of preterm fetal growth restriction. Prenat Diagn 30:395–401PubMed Kennelly MM, Farah N, Turner MJ, Stuart B (2010) Aortic isthmus Doppler velocimetry: role in assessment of preterm fetal growth restriction. Prenat Diagn 30:395–401PubMed
34.
go back to reference Figueras F, Benavides A, Del Rio M, Crispi F, Eixarch E, Martinez JM et al (2009) Monitoring of fetuses with intrauterine growth restriction: longitudinal changes in ductus venosus and aortic isthmus flow. Ultrasound Obstet Gynecol 33:39–43PubMedCrossRef Figueras F, Benavides A, Del Rio M, Crispi F, Eixarch E, Martinez JM et al (2009) Monitoring of fetuses with intrauterine growth restriction: longitudinal changes in ductus venosus and aortic isthmus flow. Ultrasound Obstet Gynecol 33:39–43PubMedCrossRef
35.
go back to reference Del Río M, Martínez JM, Figueras F, Bennasar M, Olivella A, Palacio M et al (2008) Doppler assessment of the aortic isthmus and perinatal outcome in preterm fetuses with severe intrauterine growth restriction. Ultrasound Obstet Gynecol 31:41–47PubMedCrossRef Del Río M, Martínez JM, Figueras F, Bennasar M, Olivella A, Palacio M et al (2008) Doppler assessment of the aortic isthmus and perinatal outcome in preterm fetuses with severe intrauterine growth restriction. Ultrasound Obstet Gynecol 31:41–47PubMedCrossRef
36.
go back to reference Hernandez-Andrade E, Crispi F, Benavides-Serralde JA, Plasencia W, Diesel HF, Eixarch E et al (2009) Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses. Ultrasound Obstet Gynecol 34:430–436PubMedCrossRef Hernandez-Andrade E, Crispi F, Benavides-Serralde JA, Plasencia W, Diesel HF, Eixarch E et al (2009) Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses. Ultrasound Obstet Gynecol 34:430–436PubMedCrossRef
37.
go back to reference Arduini D, Rizzo G, Soliani A, Romanini C (1991) Doppler velocimetry versus nonstress test in the antepartum monitoring of low-risk pregnancies. J Ultrasound Med 10:331–335PubMed Arduini D, Rizzo G, Soliani A, Romanini C (1991) Doppler velocimetry versus nonstress test in the antepartum monitoring of low-risk pregnancies. J Ultrasound Med 10:331–335PubMed
38.
go back to reference Almström H, Axelsson O, Cnattingius S, Ekman G, Maesel A, Ulmsten U (1992) Comparison of umbilical-artery velocimetry and cardiotocography for surveillance of small-for-gestational-age fetuses. Lancet 340:936–940PubMedCrossRef Almström H, Axelsson O, Cnattingius S, Ekman G, Maesel A, Ulmsten U (1992) Comparison of umbilical-artery velocimetry and cardiotocography for surveillance of small-for-gestational-age fetuses. Lancet 340:936–940PubMedCrossRef
39.
40.
go back to reference Belizan JM, Villar J, Nardin JC, Malamud J, De Vicurna LS (1978) Diagnosis of intrauterine growth retardation by a simple clinical method: measurement of uterine height. Am J Obstet Gynecol 131:643–646PubMed Belizan JM, Villar J, Nardin JC, Malamud J, De Vicurna LS (1978) Diagnosis of intrauterine growth retardation by a simple clinical method: measurement of uterine height. Am J Obstet Gynecol 131:643–646PubMed
41.
go back to reference Harding K, Evans S, Newnham J (1995) Screening for the small fetus: a study of the relative efficacies of ultrasound biometry and symphysiofundal height. Aust N Z J Obstet Gynaecol 35:160–164PubMedCrossRef Harding K, Evans S, Newnham J (1995) Screening for the small fetus: a study of the relative efficacies of ultrasound biometry and symphysiofundal height. Aust N Z J Obstet Gynaecol 35:160–164PubMedCrossRef
42.
go back to reference Snijders RJ, Nicolaides KH (1994) Fetal biometry at 14–40 weeks’ gestation. Ultrasound Obstet Gynecol 4:34–48PubMedCrossRef Snijders RJ, Nicolaides KH (1994) Fetal biometry at 14–40 weeks’ gestation. Ultrasound Obstet Gynecol 4:34–48PubMedCrossRef
43.
go back to reference Chang TC, Robson SC, Boys RJ, Spencer JA (1992) Prediction of the small for gestational age infant: which ultrasonic measurement is best? Obstet Gynecol 80:1030–1038PubMed Chang TC, Robson SC, Boys RJ, Spencer JA (1992) Prediction of the small for gestational age infant: which ultrasonic measurement is best? Obstet Gynecol 80:1030–1038PubMed
44.
go back to reference Shepard MJ, Richards VA, Berkowitz RL, Warsof SL, Hobbins JC (1982) An evolution of two equations for predicting fetal weight by ultrasound. Am J Obstet Gynecol 142:47–54PubMed Shepard MJ, Richards VA, Berkowitz RL, Warsof SL, Hobbins JC (1982) An evolution of two equations for predicting fetal weight by ultrasound. Am J Obstet Gynecol 142:47–54PubMed
45.
go back to reference Ott WJ, Doyle S, Flamm S, Wittman J (1986) Accurate ultrasonic estimation of fetal weight: prospective analysis of new ultrasonic formulas. Am J Perinatol 3:307–310PubMedCrossRef Ott WJ, Doyle S, Flamm S, Wittman J (1986) Accurate ultrasonic estimation of fetal weight: prospective analysis of new ultrasonic formulas. Am J Perinatol 3:307–310PubMedCrossRef
46.
go back to reference Vintzileos AM, Campbell WA, Rodis JF, Bors-Koefoed R, Nochimson DJ (1987) Fetal weight estimation formulas with head, abdominal, femur, and thigh circumference measurements. Am J Obstet Gynecol 157:410–414PubMed Vintzileos AM, Campbell WA, Rodis JF, Bors-Koefoed R, Nochimson DJ (1987) Fetal weight estimation formulas with head, abdominal, femur, and thigh circumference measurements. Am J Obstet Gynecol 157:410–414PubMed
47.
go back to reference Hadlock FP (1986) Evolution of fetal weight estimation procedures. In: Deter RL (ed) Quantitative obstetrical ultrasonography. Wiley Medical, New York Hadlock FP (1986) Evolution of fetal weight estimation procedures. In: Deter RL (ed) Quantitative obstetrical ultrasonography. Wiley Medical, New York
48.
go back to reference Divon MY, Guidetti DA, Braverman JJ, Oberlander E, Lanfer O, Merkatz IR (1988) Intrauterine growth retardation: a prospective study of the diagnostic value of real-time sonography combined with umbilical artery flow velocimetry. Obstet Gynecol 72:611–614PubMed Divon MY, Guidetti DA, Braverman JJ, Oberlander E, Lanfer O, Merkatz IR (1988) Intrauterine growth retardation: a prospective study of the diagnostic value of real-time sonography combined with umbilical artery flow velocimetry. Obstet Gynecol 72:611–614PubMed
49.
go back to reference Shalev E, Romano S, Weiner E, Ben-Ami M (1991) Predictive value of the femur length to abdominal circumference ratio in diagnosis of intrauterine growth retardation. Isr J Med Sci 27:131–133PubMed Shalev E, Romano S, Weiner E, Ben-Ami M (1991) Predictive value of the femur length to abdominal circumference ratio in diagnosis of intrauterine growth retardation. Isr J Med Sci 27:131–133PubMed
50.
go back to reference Botosis D, Vrachnis N, Christodoulakos G (2006) Doppler assessment of the intrauterine growth-restricted fetus. Ann N Y Acad Sci 1092:297–303CrossRef Botosis D, Vrachnis N, Christodoulakos G (2006) Doppler assessment of the intrauterine growth-restricted fetus. Ann N Y Acad Sci 1092:297–303CrossRef
51.
go back to reference Carrera JM (1997) Estudio hemodinâmico del deterioro fetal en el crecimiento intrauterino retardado. In: Carrera JM (ed) Crecimiento fetal normal y patológico. Masson, Barcelona, pp 389–399 Carrera JM (1997) Estudio hemodinâmico del deterioro fetal en el crecimiento intrauterino retardado. In: Carrera JM (ed) Crecimiento fetal normal y patológico. Masson, Barcelona, pp 389–399
52.
go back to reference Trudinger BJ, Cook CM, Giles WB (1991) Fetal umbilical artery velocity waveforms and subsequent neonatal outcome. Br J Obstet Gynaecol 98:378–384PubMedCrossRef Trudinger BJ, Cook CM, Giles WB (1991) Fetal umbilical artery velocity waveforms and subsequent neonatal outcome. Br J Obstet Gynaecol 98:378–384PubMedCrossRef
53.
go back to reference Montenegro CA (1992) Perfil hemodinâmico fetal—Diástole zero “revisitada”. J Bras Ginecol 102:375–380 Montenegro CA (1992) Perfil hemodinâmico fetal—Diástole zero “revisitada”. J Bras Ginecol 102:375–380
54.
go back to reference Itskowitz J, LaGamma EF, Rudolph AM (1987) Effect of cord compression on fetal blood flow distribution and O2 delivery. Am J Physiol 252:H100–H109 Itskowitz J, LaGamma EF, Rudolph AM (1987) Effect of cord compression on fetal blood flow distribution and O2 delivery. Am J Physiol 252:H100–H109
55.
go back to reference Kjellmer I, Karlsson K, Olsson T, Rosen KG (1974) Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 8:50–57PubMedCrossRef Kjellmer I, Karlsson K, Olsson T, Rosen KG (1974) Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 8:50–57PubMedCrossRef
56.
go back to reference Peeters LL, Sheldon RE, Jones MD Jr, Mahowski EL, Meschia G (1979) Blood flow to fetal organs as a function of arterial oxygen content. Am J Obstet Gynecol 135:637–646PubMed Peeters LL, Sheldon RE, Jones MD Jr, Mahowski EL, Meschia G (1979) Blood flow to fetal organs as a function of arterial oxygen content. Am J Obstet Gynecol 135:637–646PubMed
57.
go back to reference Arduini D, Rizzo G, Romanini C (1992) Changes of pulsatility index from fetal vessels preceding the onset of late decelerations in growth-retarded fetuses. Obstet Gynecol 79:605–610PubMed Arduini D, Rizzo G, Romanini C (1992) Changes of pulsatility index from fetal vessels preceding the onset of late decelerations in growth-retarded fetuses. Obstet Gynecol 79:605–610PubMed
58.
go back to reference Ferrazzi E, Pardi G, Bauscaglia M, Marconi AM, Gementi B, Bellotti M et al (1988) The correlation of biochemical monitoring versus umbilical blood flow velocity measurements of the human fetuses. Am J Obstet Gynecol 159:1081–1084PubMed Ferrazzi E, Pardi G, Bauscaglia M, Marconi AM, Gementi B, Bellotti M et al (1988) The correlation of biochemical monitoring versus umbilical blood flow velocity measurements of the human fetuses. Am J Obstet Gynecol 159:1081–1084PubMed
59.
go back to reference Bahtiyar MO, Copel JA (2008) Cardiac changes in the intrauterine growth-restricted fetus. Semin Perinatol 32:190–193PubMedCrossRef Bahtiyar MO, Copel JA (2008) Cardiac changes in the intrauterine growth-restricted fetus. Semin Perinatol 32:190–193PubMedCrossRef
60.
go back to reference Cruz Martinez R, Figueiras F, Jaramillo JJ, Meler E, Mendez A, Hernandez-Andrade E et al (2011) Learning curve for Doppler measurement of fetal modified myocardial performance index. Ultrasound Obstet Gynecol 37:158–162PubMedCrossRef Cruz Martinez R, Figueiras F, Jaramillo JJ, Meler E, Mendez A, Hernandez-Andrade E et al (2011) Learning curve for Doppler measurement of fetal modified myocardial performance index. Ultrasound Obstet Gynecol 37:158–162PubMedCrossRef
61.
go back to reference Alexandre SM, D’Almeida V, Guinsburg R, Nakamura MU, Tufik S, Moron A (2008) Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth. Int J Obstet Gynecol 100:136–140CrossRef Alexandre SM, D’Almeida V, Guinsburg R, Nakamura MU, Tufik S, Moron A (2008) Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth. Int J Obstet Gynecol 100:136–140CrossRef
62.
go back to reference Ley D, Laurin J, Bjerre I, Marsal K (1996) Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age. Ultrsound Obstet Gynecol 8:152–159CrossRef Ley D, Laurin J, Bjerre I, Marsal K (1996) Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age. Ultrsound Obstet Gynecol 8:152–159CrossRef
63.
go back to reference Wilson DC, Harper A, McClure G, Halliday HL, Reid M (1992) Long term predictive value of Doppler studies in high risk fetuses. Br J Obstet Gynaecol 99:575–578PubMedCrossRef Wilson DC, Harper A, McClure G, Halliday HL, Reid M (1992) Long term predictive value of Doppler studies in high risk fetuses. Br J Obstet Gynaecol 99:575–578PubMedCrossRef
64.
go back to reference Schreuder AM, McDonnell M, Gaffney G, Johnson A, Hope PL (2002) Outcome at school age following antenatal detection of absent or reversed end diastolic flow velocity in the umbilical artery. Arch Dis Child Fetal Neonatal Ed 82:F108–F114CrossRef Schreuder AM, McDonnell M, Gaffney G, Johnson A, Hope PL (2002) Outcome at school age following antenatal detection of absent or reversed end diastolic flow velocity in the umbilical artery. Arch Dis Child Fetal Neonatal Ed 82:F108–F114CrossRef
65.
go back to reference Skrablin S, Kalafatić D, Banović I, Kuvacić I, Juretić E, Goluza T (2000) Antenatal predictors of the neurologic sequelae at 3 years of age: a multivariate analysis. Eur J Obstet Gynecol Reprod Biol 93:173–180PubMedCrossRef Skrablin S, Kalafatić D, Banović I, Kuvacić I, Juretić E, Goluza T (2000) Antenatal predictors of the neurologic sequelae at 3 years of age: a multivariate analysis. Eur J Obstet Gynecol Reprod Biol 93:173–180PubMedCrossRef
66.
go back to reference Bilardo CM, Nicolaides KH, Campbell S (1990) Doppler measurements of fetal and uteroplacental circulations: relationship with umbilical venous blood gases measured at cordocentesis. Am J Obstet Gynecol 162:155–158 Bilardo CM, Nicolaides KH, Campbell S (1990) Doppler measurements of fetal and uteroplacental circulations: relationship with umbilical venous blood gases measured at cordocentesis. Am J Obstet Gynecol 162:155–158
67.
go back to reference Indick JH, Chen V, Reed KL (1991) Association of umbilical venous with inferior vena cava blood flow velocities. Obstet Gynecol 77:551–557 Indick JH, Chen V, Reed KL (1991) Association of umbilical venous with inferior vena cava blood flow velocities. Obstet Gynecol 77:551–557
68.
go back to reference Baschat AA (2004) Doppler application in the delivery timing of the preterm growth-restricted fetus: another step in the right direction. Ultrasound Obstet Gynecol 23:111–118PubMedCrossRef Baschat AA (2004) Doppler application in the delivery timing of the preterm growth-restricted fetus: another step in the right direction. Ultrasound Obstet Gynecol 23:111–118PubMedCrossRef
69.
go back to reference Sá RA, Chaves Netto H, Lopes LM, Barreto M, Cabral AC (2003) Dopplerfluxometria do ducto venoso—Relação com a gasometria em fetos prematuros com centralização do fluxo sanguíneo. Rev Bras Ginecol Obstet 25:261–265CrossRef Sá RA, Chaves Netto H, Lopes LM, Barreto M, Cabral AC (2003) Dopplerfluxometria do ducto venoso—Relação com a gasometria em fetos prematuros com centralização do fluxo sanguíneo. Rev Bras Ginecol Obstet 25:261–265CrossRef
70.
go back to reference Carvalho FH, Moron AF, Mattar R, Santana RM, Murta CG, Barbosa MM et al (2005) Ductus venosus Doppler velocimetry in the prediction of acidemia at birth; which is the best parameter? Prenat Diagn 25:1212–1216PubMedCrossRef Carvalho FH, Moron AF, Mattar R, Santana RM, Murta CG, Barbosa MM et al (2005) Ductus venosus Doppler velocimetry in the prediction of acidemia at birth; which is the best parameter? Prenat Diagn 25:1212–1216PubMedCrossRef
71.
go back to reference Barbosa MM, Carvalho FH, Araujo Júnior E, Nardozza LM, Santana RM, Torloni MR et al (2009) Prediction of acidemia at birth by Doppler assessment of fetal cerebral transverse sinus in pregnancies with placental insufficiency. Ultrasound Obstet Gynecol 33:188–192PubMedCrossRef Barbosa MM, Carvalho FH, Araujo Júnior E, Nardozza LM, Santana RM, Torloni MR et al (2009) Prediction of acidemia at birth by Doppler assessment of fetal cerebral transverse sinus in pregnancies with placental insufficiency. Ultrasound Obstet Gynecol 33:188–192PubMedCrossRef
72.
go back to reference Montenegro CA, Meirelles J, Fonseca AL (1992) Codocentèse et evaluation du bien-être foetal dans une population à très haute risqué. Rev Franç Gynecol Obstet 87:467–477 Montenegro CA, Meirelles J, Fonseca AL (1992) Codocentèse et evaluation du bien-être foetal dans une population à très haute risqué. Rev Franç Gynecol Obstet 87:467–477
73.
go back to reference Gembruch U (1996) Assessment of the fetal circulatory state in uteroplacental insufficiency by Doppler ultrasound: which vessels are the most practicable? Ultrasound Obstet Gynecol 8:77–81PubMedCrossRef Gembruch U (1996) Assessment of the fetal circulatory state in uteroplacental insufficiency by Doppler ultrasound: which vessels are the most practicable? Ultrasound Obstet Gynecol 8:77–81PubMedCrossRef
74.
go back to reference Ferrazzi E, Bozzo M, Rigano S, Bellotti M, Morabito A, Pardi G et al (2002) Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth restricted fetus. Ultrasound Obstet Gynecol 19:140–146PubMedCrossRef Ferrazzi E, Bozzo M, Rigano S, Bellotti M, Morabito A, Pardi G et al (2002) Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth restricted fetus. Ultrasound Obstet Gynecol 19:140–146PubMedCrossRef
75.
go back to reference Butt FT, Ahmed B (2011) The role of antepartum transabdominal amnioinfusion in the management of oligohydramnios in pregnancy. J Matern Fetal Neonatal Med 24:453–457PubMedCrossRef Butt FT, Ahmed B (2011) The role of antepartum transabdominal amnioinfusion in the management of oligohydramnios in pregnancy. J Matern Fetal Neonatal Med 24:453–457PubMedCrossRef
Metadata
Title
Fetal growth restriction: current knowledge to the general Obs/Gyn
Authors
Luciano Marcondes Machado Nardozza
Edward Araujo Júnior
Maurício Mendes Barbosa
Ana Carolina Rabachini Caetano
Desireé Ji Re Lee
Antonio Fernandes Moron
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 1/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-012-2330-6

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