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01-09-2012 | Gynecologic Oncology

Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women

Authors: Rui-Juan Cong, Zhong-Ying Huang, Ling Cong, Yi Ye, Zheng Wang, Lagabaiyila Zha, Li-Ping Cao, Xiao-Wei Su, Jing Yan, Ying-Bi Li

Published in: Archives of Gynecology and Obstetrics | Issue 3/2012

Abstract

Purpose

To evaluate the association of HSD17B1 and HSD17B2 gene polymorphisms with uterine leiomyoma in Chinese women.

Methods

121 Chinese women with clinically diagnosed uterine leiomyoma and 217 healthy normal Chinese women were investigated to compare three single nucleotide polymorphisms (SNPs) (rs605059 and rs676387 of HSD17B1 gene and rs8191246 of HSD17B2 gene) by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs were polymorphisms in Chinese women. Frequencies of rs605059 AA genotype and A allele were significantly increased in patients with uterine leiomyoma compared to healthy controls (GG vs. AA, OR 0.40, 95 % CI 0.20–0.82; G vs. A, OR 0.68, 95 % CI 0.50–0.94).

Conclusion

The results suggest that the genotype of HSD17B1 rs605059 may play a role in the tumourgenesis of uterine leiomyoma.

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Title: Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women
Authors: Rui-Juan Cong
Zhong-Ying Huang
Ling Cong
Yi Ye
Zheng Wang
Lagabaiyila Zha
Li-Ping Cao
Xiao-Wei Su
Jing Yan
Ying-Bi Li
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2328-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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