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Archives of Gynecology and Obstetrics

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01-06-2012 | Gynecologic Oncology

Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

Authors: Samer El-Safadi, Anna Sauerbier, Andreas Hackethal, Karsten Münstedt

Published in: Archives of Gynecology and Obstetrics | Issue 6/2012

Abstract

Objectives

Obesity is associated with the incidence of endometrial cancer. At present it is unclear whether it is also associated with cancer recurrence. This analysis evaluated the consequences of weight changes after diagnosis of endometrial cancer during the follow-up.

Methods

Records of patients with endometrial cancer (n = 705) were reviewed for body weight after the diagnosis of cancer during the follow-up and related to recurrence-free survival.

Results

About two-thirds of all endometrial patients gained more or less weight after the diagnosis of endometrial cancer. Patients with moderate weight gain (≤1 kg/m²) 6 months after the diagnosis had the best prognosis, followed by patients with greater weight gain (>1 kg/m²) and those with moderate weight loss (≤1 kg/m²). The fact that weight loss was associated with poor prognosis also persisted when the analysis was restricted to recurrences which occurred more than 18 months later.

Conclusions

Weight loss after the diagnosis and treatment of cancer may be an adverse prognostic factor. Although it was impossible to distinguish between intentional and non-intentional weight loss, these results argue against weight loss for risk reduction in patients with confirmed endometrial cancer. However, it may be reasonable regarding the risk reduction of non-cancer related morbidity and mortality. Detailed, prospective randomised trials are warranted.

Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–1555PubMedCrossRef

Haenle MM, Brockmann SO, Kron M et al (2006) Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults. BMC Public Health 6:233PubMedCrossRef

Calle EE, Thun MJ (2004) Obesity and cancer. Oncogene 23:6365–6378PubMedCrossRef

Bray F, Dos Santos Silva I, Moller H, Weiderpass E (2005) Endometrial cancer incidence trends in Europe: underlying determinants and prospects for prevention. Cancer Epidemiol Biomarkers Prev 14:1132–1142PubMedCrossRef

Erkanli S, Kayaselcuk F, Bagis T, Kuscu E (2006) Impact of morbid obesity in surgical management of endometrial cancer: surgical morbidity, clinical and pathological aspects. Eur J Gynaecol Oncol 27:401–404PubMed

Everett E, Tamimi H, Greer B et al (2003) The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol 90:150–157PubMedCrossRef

McCourt CK, Mutch DG, Gibb RK et al (2007) Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer. Gynecol Oncol 104:535–539PubMedCrossRef

Temkin SM, Pezzullo JC, Hellmann M, Lee YC, Abulafia O (2007) Is body mass index an independent risk factor of survival among patients with endometrial cancer? Am J Clin Oncol 30:8–14PubMedCrossRef

Münstedt K, Wagner M, Kullmer U, Hackethal A, Franke FE (2008) Influence of body mass index on prognosis in gynecological malignancies. Cancer Causes Control 19:909–916PubMedCrossRef

10.

McTiernan A, Irwin M, Vongruenigen V (2010) Weight, physical activity, diet, and prognosis in breast and gynecologic cancers. J Clin Oncol 28:4074–4080PubMedCrossRef

11.

Vahrson H (1991) Die Strahlentherapie des Korpuskarzinoms. In: Künzel W, Kirschbaum M (eds) Giessener Gynäkologische Fortbildung 1991. Springer, Berlin, pp 163–179

12.

Van Cutsem E, Arends J (2005) The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 9(Suppl 2):S51–S63PubMedCrossRef

13.

von Gruenigen VE, Gibbons HE, Kavanagh MB, Janata JW, Lerner E, Courneya KS (2009) A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change. Health Qual Life Outcomes 7:17CrossRef

14.

Chen X, Lu W, Zheng W et al (2010) Obesity and weight change in relation to breast cancer survival. Breast Cancer Res Treat 122:823–833PubMedCrossRef

15.

Caan BJ, Kwan ML, Hartzell G et al (2008) Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control 19:1319–1328PubMedCrossRef

16.

Thivat E, Thérondel S, Lapirot O et al (2010) Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer 10:648PubMedCrossRef

17.

Münstedt K, von Georgi R, Franke FE (2010) Effect of obesity on survival in epithelial ovarian cancer. Cancer 109:811–812CrossRef

18.

Alici S, Kaya S, Izmirli M (2006) Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma. Med Sci Monit 12: CR221–CR229

19.

Lecleire S, Di Fiore F, Antonietti M et al (2006) Undernutrition is predictive of early mortality after palliative self-expanding metal stent insertion in patients with inoperable or recurrent esophageal cancer. Gastrointest Endosc 64:479–484PubMedCrossRef

20.

Parker AS, Lohse CM, Cheville JC, Thiel DD, Leibovich BC, Blute ML (2006) Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology 68:741–746PubMedCrossRef

21.

von Gruenigen VE, Tian C, Frasure H, Waggoner S, Keys H, Barakat RR (2006) Treatment effects, disease recurrence, and survival in obese women with early endometrial carcinoma: a Gynecologic Oncology Group study. Cancer 107:2786–2791CrossRef

Title: Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis
Authors: Samer El-Safadi
Anna Sauerbier
Andreas Hackethal
Karsten Münstedt
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 6/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2224-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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