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01-03-2012 | Maternal-Fetal Medicine

Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1

Authors: Christoph Scholz, Christine Hermann, Andrea Kachler, Franz Kainer, Klaus Friese, Antonios Makrigiannakis, Udo Jeschke

Published in: Archives of Gynecology and Obstetrics | Issue 3/2012

Abstract:

Background

Fetomaternal hemorrhage (FMH) poses an immediate risk to the fetus and, in case of Rhesus-immunization, to future pregnancies. Given that altered endothelial permeability is part of the pathophysiology of inflammation, in this study we investigated whether placental inflammatory processes like chorioamnionitis (ChoA) or preeclampsia (PE) lead to increased rates of FMH compared to the established risk factor of placenta previa (PP). Putative accompanying markers of trophoblastic damage were also explored.

Methods

40 patients (14 PE; 6 ChoA; 9 PP; 11 normal controls) were evaluated for FMH using a flowcytometric test kit, which is able to quantify FMH of 0.06% fetal cells. Placental tissue samples were immunostained for human placental lactogen (hPL), human chorionic gonadotropin (hCG), and mucin-1 (MUC1). MUC1 was evaluated as a potential serum marker of FMH.

Results

Patients with ChoA had a mean calculated FMH volume of 29 ml, compared to 4 ml in PE and 1 ml in PP and controls. MUC1 staining was reduced in PE and ChoA placenta samples, while elevated MUC1 serum concentration correlated positively with FMH.

Conclusion

Diseases of placental inflammation are associated with FMH. Placental MUC1 staining is reduced and serum concentrations are increased in cases of FMH.

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Title: Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1
Authors: Christoph Scholz
Christine Hermann
Andrea Kachler
Franz Kainer
Klaus Friese
Antonios Makrigiannakis
Udo Jeschke
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2028-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1

Abstract:

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract:

Background

Methods

Results

Conclusion

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