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Archives of Gynecology and Obstetrics

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01-02-2012 | Gynecologic Oncology

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Authors: A. Kondi-Pafiti, E. Papakonstantinou, C. Iavazzo, C. Grigoriadis, N. Salakos, O. Gregoriou

Published in: Archives of Gynecology and Obstetrics | Issue 2/2012

Abstract

Introduction

Substantial histopathology data provide evidence that endometriosis might be viewed as a precursor lesion of endometrioid and clear cell carcinoma of the ovary, via intermediary atypical borderline lesions. Also, genes involved in both endometriosis and epithelial ovarian cancer have been shown to play a role in the pathogenesis of endometriosis-associated ovarian carcinoma.

Material and methods

A retrospective study of 17 cases of ovarian carcinomas associated with endometriosis, diagnosed between 2000 and 2009, at Aretaieion Hospital of University of Athens, is presented. 10/17 cases in this study (58.8%) were clear cell carcinomas (CCC), 6/17 cases (35.3%) were endometrioid adenocarcinomas (EAC) and 1/17 cases (5.9%) was a serous carcinoma associated with ovarian endometriosis. Patients’s age was 27–76 years (mean age 58 years). Typical ovarian endometriosis was documented in 8/17 (47%) of the tumors. In 9/17 cases, areas of fibrosis or cystic lesions infiltrated by iron-laden macrophages and endometrial-like stroma, consistent with endometriosis, were observed.

Conclusion

In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management.

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Title: Clinicopathological characteristics of ovarian carcinomas associated with endometriosis
Authors: A. Kondi-Pafiti
E. Papakonstantinou
C. Iavazzo
C. Grigoriadis
N. Salakos
O. Gregoriou
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1957-z

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Springer Medicine

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Abstract

Introduction

Material and methods

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Material and methods

Conclusion

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