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Archives of Gynecology and Obstetrics

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01-11-2010 | General Gynecology

HTLV infection and its implication in gynaecology and obstetrics

Authors: Ioannis Mylonas, Ansgar Brüning, Franz Kainer, Klaus Friese

Published in: Archives of Gynecology and Obstetrics | Issue 5/2010

Abstract

Introduction

Worldwide, 20–30 million people are estimated to be infected with HTLV. HTLV-1 is endemic in Western Africa and Southern Japan, whereas HTLV-2 is considered to be spread among native American people.

Materials and methods

The impact of HTLV in gynaecology and obstetrics is being reviewed. Search strategy and selection criteria for identifying relevant data were peformed by searching Medline, Current Contents, Web of Science, Embase and references from relevant articles. English and German gynaecological and infectious diseases textbooks as well as national and international guidelines and recommendations were also reviewed.

Results

Transmission may occur by sexual intercourse or cellular blood products. Although materno-fetal transmission is debated, transmission through maternal breast milk has been confirmed. An HTLV-infection can lead to adult T-cell leukaemia (ATL) or cumulative opportunistic and neurological disorders that can occur with varying degrees of severity. Diagnosis can be done by antibody detection via the use of ELISA and western blot analysis as well as PCR diagnosis.

Conclusion

Due to inadequate treatment options and the lack of an effective vaccination, prevention is currently only possible by restricting transmission, including the usage of condoms during sexual intercourse or avoiding breastfeeding in HTLV-seropositive mothers. If, due to socio-economic reasons, breastfeeding cannot be avoided, short-term breastfeeding for a maximum of up to 6 months is suggested.

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Title: HTLV infection and its implication in gynaecology and obstetrics
Authors: Ioannis Mylonas
Ansgar Brüning
Franz Kainer
Klaus Friese
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1559-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

HTLV infection and its implication in gynaecology and obstetrics

Abstract

Introduction

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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