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01-11-2010 | Materno-fetal Medicine

Role of oxidative stress in the pathogenesis of preeclampsia

Authors: Imran A. Siddiqui, Anila Jaleel, Waleed Tamimi, Hanan M. F. Al Kadri

Published in: Archives of Gynecology and Obstetrics | Issue 5/2010

Abstract

Hypertensive disorders of pregnancy are associated with an increased risk of maternal and fetal morbidity and mortality. The cause and the pathogenesis of the pregnancy-induced syndrome, preeclampsia, is still poorly understood. Published evidence of altered biomarkers for the endothelial dysfunction suggests that the initiating event in preeclampsia is the reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium. This review focuses on the role of free radicals in generating the oxidative stress taking antioxidants into consideration which tend to overcome it as well as the role of placenta in preeclamptic pregnancy.

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Title: Role of oxidative stress in the pathogenesis of preeclampsia
Authors: Imran A. Siddiqui
Anila Jaleel
Waleed Tamimi
Hanan M. F. Al Kadri
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1538-6

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Role of oxidative stress in the pathogenesis of preeclampsia

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