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Archives of Gynecology and Obstetrics

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01-12-2009 | Original Article

A randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor

Authors: Arvind Vaid, Vatsla Dadhwal, Suneeta Mittal, Deepika Deka, Renu Misra, Jai Bhagwan Sharma, N. Vimla

Published in: Archives of Gynecology and Obstetrics | Issue 6/2009

Abstract

Objective

To compare the efficacy and side effects of 0.2 mg methyl-ergometrine IM, 400 μg misoprostol sublingual and 125 μg 15 methyl PGF2α IM in active management of third stage of labor.

Method

Two hundred low risk pregnant women with induced or spontaneous labor were randomized to receive either 400 μg misoprostol sublingually or 0.2 mg methyl-ergometrine intramuscularly or 125 μg 15-methyl PGF2α intramuscularly, after the delivery of anterior shoulder of baby. The main outcome measures were: blood loss more than 500 ml, need for additional oxytoxic drug, change in hemoglobin level and side effects due to drugs.

Results

The median estimated blood loss, blood loss more than 500 ml, need for additional oxytocic drug and change in hemoglobin levels were similar in all three groups. The significant side effects in the misoprostol group were shivering, pyrexia (temperature > 38°C) and vomiting, which were self-limiting. Diarrhea was significantly more in the 15 methyl PGF2α group. Three women in methyl-ergometrine group underwent manual removal of placenta. One woman in misoprostol group received blood transfusion.

Conclusion

Sublingual misoprostol appears to be as effective as intramuscular methyl-ergometrine and intramuscular 15-methyl PGF2α in the prevention of postpartum hemorrhage. It can be a good alternative in resource poor setting.

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Title: A randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor
Authors: Arvind Vaid
Vatsla Dadhwal
Suneeta Mittal
Deepika Deka
Renu Misra
Jai Bhagwan Sharma
N. Vimla
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 6/2009
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1019-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor

Abstract

Objective

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

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