Published in:
01-01-2009 | Original Article
Vaginal misoprostol for cervical priming prior to diagnostic hysteroscopy––efficacy, safety and patient satisfaction: a randomized controlled trial
Published in: Archives of Gynecology and Obstetrics | Issue 1/2009
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Objective
To evaluate the effectiveness and safety of vaginal misoprostol for cervical priming prior to diagnostic hysteroscopy and to assess impact on pain scores and patient satisfaction.
Methods
One hundred women undergoing hysteroscopy were randomly allocated into two groups. The study group (n = 50) received 400 µg of misoprostol vaginally (self administered) 4–6 h prior to hysteroscopy while the control group (n = 50) did not receive any cervical priming. Primary outcome measured was need for cervical dilatation, analgesia or sedation. Secondary outcomes were pain scores, patient satisfaction and side effects.
Results
There was no significant difference in the need for cervical dilatation, analgesia or sedation in the two groups (P = 0.25, 0.64 and 0.5, respectively). In addition, there was no difference in subjective patient satisfaction (P = 0.70). However, those in the control group recorded a higher pain score (median ± SD = 5 ± 1.8) when compared to those who received misoprostol (median ± SD = 4.5 ± 2, P = 0.03). Only two women (4%) had bleeding per vaginum and one (2%) had a slight fever attributable to misoprostol.
Conclusion
Vaginal misoprostol prior to diagnostic hysteroscopy did not facilitate cervical dilatation. It did effect a reduction in pain scores, but there was no difference in patient satisfaction, need for analgesia or sedation. No significant side effects were reported.