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Published in: Archives of Gynecology and Obstetrics 6/2008

01-06-2008 | Review Article

Aggressive angiomyxoma of the vulva: a case report and review of literature

Authors: Inge Dierickx, Karen Deraedt, Willy Poppe, Jasper Verguts

Published in: Archives of Gynecology and Obstetrics | Issue 6/2008

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Abstract

Background

Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasize.

Case report

We describe a case of AA in the left labium majus pudendi in a 47-year-old woman who underwent incomplete surgical excision. Follow-up 2 years later revealed no recurrence.

Conclusion

In the past, most authors advocated wide excision even if genitourinary and digestive tract resection were necessary. These days, a less radical surgery is recommended, but the significance of hormonal treatment and/or radiation therapy is not clear yet. Further investigation is necessary.
Literature
1.
go back to reference Steeper TA (1983) Aggressive angiomyxoma of the female pelvis and perineum: report of nine cases of an distinctive type of gynaecologic soft-tissue neoplasm. Am J Surg Pathol 7:463–475PubMedCrossRef Steeper TA (1983) Aggressive angiomyxoma of the female pelvis and perineum: report of nine cases of an distinctive type of gynaecologic soft-tissue neoplasm. Am J Surg Pathol 7:463–475PubMedCrossRef
2.
go back to reference Magtibay PM, Salmon Z, Keeney GL, Podratz KC (2006) Aggressive angiomyxoma of the female pelvis and perineum: a case series. Int J Gynecol Cancer 16:396–401PubMedCrossRef Magtibay PM, Salmon Z, Keeney GL, Podratz KC (2006) Aggressive angiomyxoma of the female pelvis and perineum: a case series. Int J Gynecol Cancer 16:396–401PubMedCrossRef
3.
go back to reference Chan YM, Hon E, Ngai SW, Ng TY, Wong LC, Chan IM (2000) Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand 79:216–220PubMedCrossRef Chan YM, Hon E, Ngai SW, Ng TY, Wong LC, Chan IM (2000) Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand 79:216–220PubMedCrossRef
4.
go back to reference Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM (1996) Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer 78:79–90PubMedCrossRef Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM (1996) Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer 78:79–90PubMedCrossRef
5.
go back to reference Behranwala KA, Thomas JM (2003) Aggressive angiomyxoma: a distinct clinical entity. Eur J Surg Oncol 29:559–563PubMedCrossRef Behranwala KA, Thomas JM (2003) Aggressive angiomyxoma: a distinct clinical entity. Eur J Surg Oncol 29:559–563PubMedCrossRef
6.
go back to reference Smith HO, Worrell RV, Smith AY, Dorin MH, Rosenberg RD, Bartow SA (1991) Aggressive angiomyxoma of the female pelvis and perineum: review of the literature. Gynecol Oncol 42:79–85PubMedCrossRef Smith HO, Worrell RV, Smith AY, Dorin MH, Rosenberg RD, Bartow SA (1991) Aggressive angiomyxoma of the female pelvis and perineum: review of the literature. Gynecol Oncol 42:79–85PubMedCrossRef
7.
go back to reference Han-Geurts IJM, van Geel AN, van Doorn L, den Bakker M, Eggermont AMM, Verhoef C (2006) Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery. J Cancer Surg 32:1217–1221 Han-Geurts IJM, van Geel AN, van Doorn L, den Bakker M, Eggermont AMM, Verhoef C (2006) Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery. J Cancer Surg 32:1217–1221
8.
9.
go back to reference Chen L, Schink JC, Panares BN, Barbuto D, Lagasse LD (1998) Resection of a giant aggressive angiomyxoma in the Philippines. Gynecol Oncol 70:435–439PubMedCrossRef Chen L, Schink JC, Panares BN, Barbuto D, Lagasse LD (1998) Resection of a giant aggressive angiomyxoma in the Philippines. Gynecol Oncol 70:435–439PubMedCrossRef
10.
go back to reference Rotmensch EJ, Kasznica J, Hamid MA (1983) Immunohistochemical analysis of hormone receptors and proliferating cell nuclear antigen in aggressive angiomyxoma of the vulva. Int J Gynecol Obstet 41:171–179CrossRef Rotmensch EJ, Kasznica J, Hamid MA (1983) Immunohistochemical analysis of hormone receptors and proliferating cell nuclear antigen in aggressive angiomyxoma of the vulva. Int J Gynecol Obstet 41:171–179CrossRef
11.
go back to reference Granter SR, Nucci MR, Fletcher CDM (1997) Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology 30:3–10PubMedCrossRef Granter SR, Nucci MR, Fletcher CDM (1997) Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology 30:3–10PubMedCrossRef
12.
go back to reference Nemoto T, Shinoda M, Komatsuzaki K, et al (1994) Myxoid leiomyomas of the vulva mimicking aggressive angiomyxoma. Pathol Int 44:454–459PubMed Nemoto T, Shinoda M, Komatsuzaki K, et al (1994) Myxoid leiomyomas of the vulva mimicking aggressive angiomyxoma. Pathol Int 44:454–459PubMed
13.
go back to reference Siassi RM (1992) Metastasizing aggressive angiomyxoma. N Engl J Med 2:1772 Siassi RM (1992) Metastasizing aggressive angiomyxoma. N Engl J Med 2:1772
14.
go back to reference Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V (2003) Aggressive angiomyxoma: a second case of metastasis with patient’s death. Hum Pathol 34:1072–1074PubMedCrossRef Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V (2003) Aggressive angiomyxoma: a second case of metastasis with patient’s death. Hum Pathol 34:1072–1074PubMedCrossRef
15.
go back to reference Begin LR, Clement PB, Kirk ME, Jotny S, McCaugney WTE, Ferenczy A (1985) Aggressive angiomyxoma of pelvic soft parts. Hum Pathol 16:621–628PubMedCrossRef Begin LR, Clement PB, Kirk ME, Jotny S, McCaugney WTE, Ferenczy A (1985) Aggressive angiomyxoma of pelvic soft parts. Hum Pathol 16:621–628PubMedCrossRef
16.
go back to reference Amezcua CA, Begley SJ, Mata N, Felix JC, Ballard CA (2005) Aggressive angiomyxoma of the female tract: a clinicopathologic and immunohistochemical study of 12 cases. Int J Gynecol Cancer 15:140–145PubMedCrossRef Amezcua CA, Begley SJ, Mata N, Felix JC, Ballard CA (2005) Aggressive angiomyxoma of the female tract: a clinicopathologic and immunohistochemical study of 12 cases. Int J Gynecol Cancer 15:140–145PubMedCrossRef
17.
go back to reference van Roggen JF, van Unnik JA, Briaire-de Bruijn IH, Hogendoorn PC (2005) Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up. Virchows Arch Pathol Anat Physiol Klin Med 446:157–163 van Roggen JF, van Unnik JA, Briaire-de Bruijn IH, Hogendoorn PC (2005) Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up. Virchows Arch Pathol Anat Physiol Klin Med 446:157–163
18.
go back to reference McCluggage WG, Patterson A, Maxwell P (2000) Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity. J Clin Pathol 53:603–605PubMedCrossRef McCluggage WG, Patterson A, Maxwell P (2000) Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity. J Clin Pathol 53:603–605PubMedCrossRef
19.
go back to reference Mascarenhas L, Knaggs J, Clark J, Eliot B (1993) Aggressive angiomyxoma of the female pelvis and perineum: case report and literature review. Am J Obstet Gynecol 169:555–556PubMed Mascarenhas L, Knaggs J, Clark J, Eliot B (1993) Aggressive angiomyxoma of the female pelvis and perineum: case report and literature review. Am J Obstet Gynecol 169:555–556PubMed
20.
go back to reference Han-Ching L, Chia-Chu L, Wan-Yi K, et al (2006) Huge aggressive angiomyxoma: a case report and literature review. Kaohsiung J Med Sci 22(6):301–303CrossRef Han-Ching L, Chia-Chu L, Wan-Yi K, et al (2006) Huge aggressive angiomyxoma: a case report and literature review. Kaohsiung J Med Sci 22(6):301–303CrossRef
21.
go back to reference Amr SS, el-Mallah KO (1995) Aggressive angiomyxoma of the vagina. Int J Gynaecol Obstet 48:207–210PubMedCrossRef Amr SS, el-Mallah KO (1995) Aggressive angiomyxoma of the vagina. Int J Gynaecol Obstet 48:207–210PubMedCrossRef
22.
go back to reference Yaghoobian J, Zinn D, Ramanathan K, Pinck RL, Hilfer J (1987) Ultrasound and computed tomographic findings in aggressive angiomyxoma of the uterine cervix. J Ultrasound Med 6:209–212PubMed Yaghoobian J, Zinn D, Ramanathan K, Pinck RL, Hilfer J (1987) Ultrasound and computed tomographic findings in aggressive angiomyxoma of the uterine cervix. J Ultrasound Med 6:209–212PubMed
23.
go back to reference Dragoumis K, Drevelengas A, et al (2005) Aggressive angiomyxoma of the vulva extending into the pelvis: report of two cases. J Obstet Gynaecol 31(4):310–313 Dragoumis K, Drevelengas A, et al (2005) Aggressive angiomyxoma of the vulva extending into the pelvis: report of two cases. J Obstet Gynaecol 31(4):310–313
24.
go back to reference Outwater EK, Marchetto BE, Wagner BJ, Siegelman ES (1999). Aggressive angiomyxoma: findings on CT and MR imaging. AJR Am J Roentgenol 172:435–438PubMed Outwater EK, Marchetto BE, Wagner BJ, Siegelman ES (1999). Aggressive angiomyxoma: findings on CT and MR imaging. AJR Am J Roentgenol 172:435–438PubMed
25.
26.
go back to reference Steiner E, Schadmand-Fischer S, Schunk K, Bezzi I, Weikel W, Pilch H, Knapstein PG (2001) Perineal excision of a large angiomyxoma in a young woman following magnetic resonance and angiographic imaging. Gynecol Oncol 82(3):568–570PubMedCrossRef Steiner E, Schadmand-Fischer S, Schunk K, Bezzi I, Weikel W, Pilch H, Knapstein PG (2001) Perineal excision of a large angiomyxoma in a young woman following magnetic resonance and angiographic imaging. Gynecol Oncol 82(3):568–570PubMedCrossRef
27.
go back to reference Fishman A, Otey LP, Poindexter AN 3rd, Shannon RL, Girtanner RE, Kaplan AL (1995) Aggressive angiomyxoma of the pelvis and perineum. A case report. J Reprod Med 40(9):665–669PubMed Fishman A, Otey LP, Poindexter AN 3rd, Shannon RL, Girtanner RE, Kaplan AL (1995) Aggressive angiomyxoma of the pelvis and perineum. A case report. J Reprod Med 40(9):665–669PubMed
28.
go back to reference Simo M, Zapata C, Esquius J, Domingo J (1992) Aggressive angiomyxoma of the female pelvis and perineum: report of two cases and review of the literature. Br J Obstet Gynaecol 99:925–927PubMed Simo M, Zapata C, Esquius J, Domingo J (1992) Aggressive angiomyxoma of the female pelvis and perineum: report of two cases and review of the literature. Br J Obstet Gynaecol 99:925–927PubMed
29.
go back to reference Poirier M, Fraser R, Meterissian S (2003) Unusual abdominal and pelvic tumors: case 1. aggressive angiomyxoma of the pelvis: response to luteinizing hormone-releasing hormone agonist. J Clin Oncol 18:3535–3536CrossRef Poirier M, Fraser R, Meterissian S (2003) Unusual abdominal and pelvic tumors: case 1. aggressive angiomyxoma of the pelvis: response to luteinizing hormone-releasing hormone agonist. J Clin Oncol 18:3535–3536CrossRef
30.
go back to reference McCluggage WG, Jamieson T, Dobbs SP, Grey A (2006) Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy. Gynecol Oncol 100:623–625PubMedCrossRef McCluggage WG, Jamieson T, Dobbs SP, Grey A (2006) Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy. Gynecol Oncol 100:623–625PubMedCrossRef
31.
go back to reference Brooks SE, Balidimos KL, Reuter KL, Khan A (1998) Virtual consult: aggressive angiomyxoma of the vulva: impact of GnRH agonists. Medscape Womens Health 3:1–5 Brooks SE, Balidimos KL, Reuter KL, Khan A (1998) Virtual consult: aggressive angiomyxoma of the vulva: impact of GnRH agonists. Medscape Womens Health 3:1–5
32.
go back to reference Fine BA, Munoz AK, Litz CE, Gershenson DM (2001) Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist. Gynecol Oncol 81:120–122PubMedCrossRef Fine BA, Munoz AK, Litz CE, Gershenson DM (2001) Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist. Gynecol Oncol 81:120–122PubMedCrossRef
33.
go back to reference Shinohara N, Nonomura K, Ishikawa S, Seki H, Koyanagi T (2004) Medical management of recurrent aggressive angiomyxoma with gonadotropin-relaesing hormone agonist. Int J Urol 11:432–435PubMedCrossRef Shinohara N, Nonomura K, Ishikawa S, Seki H, Koyanagi T (2004) Medical management of recurrent aggressive angiomyxoma with gonadotropin-relaesing hormone agonist. Int J Urol 11:432–435PubMedCrossRef
34.
go back to reference Fine BA, Munoz AK, Litz CE, Gershenson DM (2001) Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist. Gynecol Oncol 81:120–122PubMedCrossRef Fine BA, Munoz AK, Litz CE, Gershenson DM (2001) Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist. Gynecol Oncol 81:120–122PubMedCrossRef
35.
go back to reference Magtibay PM, Salmon Z, Keeney GL, Podratz KC (2006). Aggressive angiomyxoma of the female pelvis and perineum: a case series. Int J Gynecol Cancer 16:396–401PubMedCrossRef Magtibay PM, Salmon Z, Keeney GL, Podratz KC (2006). Aggressive angiomyxoma of the female pelvis and perineum: a case series. Int J Gynecol Cancer 16:396–401PubMedCrossRef
36.
go back to reference Dove S, et al Unusual female pelvic tumour: aggressive angiomyxoma. Eur J Obstet Gynecol (in press) Dove S, et al Unusual female pelvic tumour: aggressive angiomyxoma. Eur J Obstet Gynecol (in press)
37.
go back to reference Rhomberg W, Jasarevic Z, Alton R (2000) Aggressive angiomyxoma of the pelvis: irradiation for recurrent disease. Strahlenther Onkol 176:324–326PubMedCrossRef Rhomberg W, Jasarevic Z, Alton R (2000) Aggressive angiomyxoma of the pelvis: irradiation for recurrent disease. Strahlenther Onkol 176:324–326PubMedCrossRef
38.
go back to reference Nyam DCNK, Pemberton JH (1998) Large aggressive angiomyxoma of the perineum and pelvis: an alternative approach: report of a case. Dis Colon Rectum 41:514–6516PubMedCrossRef Nyam DCNK, Pemberton JH (1998) Large aggressive angiomyxoma of the perineum and pelvis: an alternative approach: report of a case. Dis Colon Rectum 41:514–6516PubMedCrossRef
39.
go back to reference Behranwala KA, Thomas JM (2003) “Aggressive” angiomyxoma: a distinct clinical entity. Eur J Surg Oncol 29(7):559–563PubMedCrossRef Behranwala KA, Thomas JM (2003) “Aggressive” angiomyxoma: a distinct clinical entity. Eur J Surg Oncol 29(7):559–563PubMedCrossRef
Metadata
Title
Aggressive angiomyxoma of the vulva: a case report and review of literature
Authors
Inge Dierickx
Karen Deraedt
Willy Poppe
Jasper Verguts
Publication date
01-06-2008
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 6/2008
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-008-0561-3

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