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Archives of Gynecology and Obstetrics

Published in:

01-08-2006 | Original Article

Tamoxifen citrate for women with unexplained infertility

Author: Tarek A. Shokeir

Published in: Archives of Gynecology and Obstetrics | Issue 5/2006

Abstract

Objective

To assess whether administration of tamoxifen citrate (TMX) to women with unexplained infertility is beneficial. The primary outcome was the clinical pregnancy rate.

Study design

In a prospective randomized trial, 66 consecutive women with unexplained infertility were recruited for the study. Thirty-six women received TMX at a 20-mg dosage and 30 women received no ovulation-induction drugs.

Results

Fourteen patients in the TMX group stopped taking TMX, and observations were terminated because of antiestrogenic effects. The pregnancy rate (PR) per patient and the PR per cycle were significantly decreased (P < 0.005) in the TMX group than in the spontaneous group. Kaplan–Meier tests showed that the cumulative PR in the TMX group was significantly lower than in the spontaneous group (P < 0.05). Ten of 14 patients who had stopped taking TMX became pregnant in spontaneous cycles.

Conclusions

Administration of tamoxifen to women with unexplained infertility is not efficacious in terms of increasing the clinical PR.

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Title: Tamoxifen citrate for women with unexplained infertility
Author: Tarek A. Shokeir
Publication date: 01-08-2006
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2006
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-006-0181-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tamoxifen citrate for women with unexplained infertility

Abstract

Objective

Study design

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Study design

Results

Conclusions

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