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Archives of Gynecology and Obstetrics

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01-11-2004 | Review Article

Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish

Authors: Kaushik Deb, Madan Mohan Chaturvedi, Yogesh Kumar Jaiswal

Published in: Archives of Gynecology and Obstetrics | Issue 3/2004

Abstract

Introduction

Intrauterine infection is frequently associated with pregnancy loss in pregnant women.

Discussion

This article reviews the role of Gram-negative bacterial infection in various complications related to early pregnancy and subsequent pregnancy loss. Here we discus the pathways of ascending intrauterine infection, microbiology and the pathophysiology of such infections. The clinical impact, therapy, consequences, prevention and implications of Gram-negative bacterial infections in women during their reproductive life span is also discussed. This article also makes an attempt to discuss our studies and findings, related to the effect of the LPS component of the Gram-negative bacterial endotoxin on preimplantation stage embryonic development and implantation. This early phase of pregnancy remains mostly unnoticed by the mother as well as the health care provider, and therefore holds more threat to the life of the fetus and the mother. The molecular mechanisms of LPS-induced pregnancy losses through abnormal embryonic development, implantation failure, and preterm labor and birth with specific references to the role of proinflammatory cytokines like IL-1 and TNF are discussed.

Conclusion

Once these inflammatory mediators have increased in the feto-maternal tissues, it may be too late or harmful to try and prevent the adverse outcomes of pregnancy.

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Title: Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish
Authors: Kaushik Deb
Madan Mohan Chaturvedi
Yogesh Kumar Jaiswal
Publication date: 01-11-2004
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2004
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-004-0623-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish

Abstract

Introduction

Discussion

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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