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Archives of Gynecology and Obstetrics

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01-09-2004 | Original Article

Adhesion molecules, activin and inhibin—candidates for the biochemical prediction of hypertensive diseases in pregnancy?

Authors: Claudia G. Hanisch, Kerstin A. Pfeiffer, Harald Schlebusch, Jan Schmolling

Published in: Archives of Gynecology and Obstetrics | Issue 2/2004

Abstract

Background

The aim of the prospective study was to compare standard parameters as Doppler ultrasound and 24-h blood pressure measurement with possible maternal serological markers regarding their prognostic value in predicting hypertensive diseases in pregnancy.

Materials

Twenty-four-hour blood pressure measurement was performed before and after 32+0 gestational week in 57 pregnant women with either chronic hypertension (n=13), preeclampsia (n=21), pregnancy-induced hypertension (PIH; n=12) or normotension (n=11). Blood samples were taken and the concentrations of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), activin A and inhibin A were determined as well as serum uric acid, creatinine, total serum protein and serum albumin. Doppler ultrasound of the uterine arteries was examined before 32+0 gestational week in the same patients. For the statistical evaluation Kruskal-Wallis-Test and Mann-Whitney-U-Test were performed. Differences in the predictive value were evaluated by receiver-operating characteristics.

Results

VCAM-1 was significantly elevated in women developing hypertensive diseases as compared to normotensive women (preeclampsia: p<0.001; PIH: p<0.05; chronic hypertension: p<0.001). In early pregnancy activin A and inhibin A were significantly higher in preeclamptic patients than in the other groups (activin A: normotension: p<0.005; PIH: p<0.001; chronic hypertension: p<0.005) (inhibin A: normotension: p<0.005; PIH: p<0.001; chronic hypertension: p<0.01), thus suggesting them to be specific markers for the development of preeclampsia. Mean arterial pressure was significantly elevated in preeclampsia (p<0.001) and chronic hypertension (p<0.005) as compared to normotensives.

Conclusion

Twenty-four-hour blood pressure monitoring with determination of mean arterial pressure and measurement of VCAM-1, activin A and inhibin A as serum parameters can be suggested as useful tests in the specific prediction of different types of hypertensive diseases in pregnancy.

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Title: Adhesion molecules, activin and inhibin—candidates for the biochemical prediction of hypertensive diseases in pregnancy?
Authors: Claudia G. Hanisch
Kerstin A. Pfeiffer
Harald Schlebusch
Jan Schmolling
Publication date: 01-09-2004
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2004
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-003-0514-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Adhesion molecules, activin and inhibin—candidates for the biochemical prediction of hypertensive diseases in pregnancy?

Abstract

Background

Materials

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Materials

Results

Conclusion

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