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Archives of Gynecology and Obstetrics

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01-01-2004 | Original Article

The effect of metformin treatment to ovarian response in cases with PCOS

Authors: Seval Tasdemir, Cem Ficicioglu, Serap Yalti, Birgül Gurbuz, Toygun Basaran, Gazi Yildirim

Published in: Archives of Gynecology and Obstetrics | Issue 2/2004

Abstract

Objective.

To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients.

Design.

Randomized prospective study.

Setting.

Zeynep Kamil Hospital IVF Center.

Patients.

Thirty-two female PCOS patients with clomiphene citrate resistance.

Interventions.

Test group A received 2×850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B.

Main outcome measures.

Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with ≥16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate.

Results.

The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group.

Conclusions.

Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.

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Title: The effect of metformin treatment to ovarian response in cases with PCOS
Authors: Seval Tasdemir
Cem Ficicioglu
Serap Yalti
Birgül Gurbuz
Toygun Basaran
Gazi Yildirim
Publication date: 01-01-2004
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2004
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-002-0447-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of metformin treatment to ovarian response in cases with PCOS

Abstract

Objective.

Design.

Setting.

Patients.

Interventions.

Main outcome measures.

Results.

Conclusions.

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective.

Design.

Setting.

Patients.

Interventions.

Main outcome measures.

Results.

Conclusions.

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