Published in:
01-11-2003 | Original Article
Interleukin-6 levels in hyperemesis gravidarum
Authors:
Naci K. Kuscu, Yasemin Yildirim, Faik Koyuncu, Ahmet Var, Bekir S. Uyanik
Published in:
Archives of Gynecology and Obstetrics
|
Issue 1/2003
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Abstract
Introduction.
Hyperemesis gravidarum (HG) is associated with higher levels of serum β-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of β-hCG from trophoblastic cell line.
Methods.
We measured serum levels of IL-6, thyroid hormones and β-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups.
Results.
There was a significant difference in β-hCG (p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with β-hCG (r=0.38 and p=0.13).