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Published in: Archives of Gynecology and Obstetrics 1/2003

01-11-2003 | Original Article

Interleukin-6 levels in hyperemesis gravidarum

Authors: Naci K. Kuscu, Yasemin Yildirim, Faik Koyuncu, Ahmet Var, Bekir S. Uyanik

Published in: Archives of Gynecology and Obstetrics | Issue 1/2003

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Abstract

Introduction.

Hyperemesis gravidarum (HG) is associated with higher levels of serum β-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of β-hCG from trophoblastic cell line.

Methods.

We measured serum levels of IL-6, thyroid hormones and β-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups.

Results.

There was a significant difference in β-hCG (p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with β-hCG (r=0.38 and p=0.13).
Literature
1.
go back to reference Agarwal R, Loganath A, Roy AC, Wong YC, Lindoff C, Ng SC (2000) Increased expression of interleukin 6 in term compared to the first trimester human placental villi. Horm Metab Res 332:164–168CrossRef Agarwal R, Loganath A, Roy AC, Wong YC, Lindoff C, Ng SC (2000) Increased expression of interleukin 6 in term compared to the first trimester human placental villi. Horm Metab Res 332:164–168CrossRef
2.
go back to reference Asakura H, Watanabe S, Sekiguchi A, Power GC, Araki T (2000) Severity of hyperemesis gravidarum correlates with serum levels of reverse T3. Arch Gynecol Obstet 264:57–62CrossRefPubMed Asakura H, Watanabe S, Sekiguchi A, Power GC, Araki T (2000) Severity of hyperemesis gravidarum correlates with serum levels of reverse T3. Arch Gynecol Obstet 264:57–62CrossRefPubMed
3.
go back to reference Fairweather DVI, Loraine JA (1968) Nausea and vomiting in pregnancy. Am J Obstet Gynecol 102:135–173CrossRefPubMed Fairweather DVI, Loraine JA (1968) Nausea and vomiting in pregnancy. Am J Obstet Gynecol 102:135–173CrossRefPubMed
4.
go back to reference Goodwin TM, Montero M, Mestman JH (1992) Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am J Obstet Gynecol 167:648–652CrossRefPubMed Goodwin TM, Montero M, Mestman JH (1992) Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am J Obstet Gynecol 167:648–652CrossRefPubMed
5.
go back to reference Hershman JM (1999) Human chorionic gonadotropin and the thyroid: hyperemesis gravidarum and trophoblastic tumors. Thyroid 9:653–657CrossRefPubMed Hershman JM (1999) Human chorionic gonadotropin and the thyroid: hyperemesis gravidarum and trophoblastic tumors. Thyroid 9:653–657CrossRefPubMed
6.
go back to reference Jauniaux E, Gulbis B, Schandene L, Collette J, Hustin J (1996) Distribution of interleukin-6 in maternal and embryonic tissues during the first trimester. Mol Hum Reprod 2:239–243CrossRefPubMed Jauniaux E, Gulbis B, Schandene L, Collette J, Hustin J (1996) Distribution of interleukin-6 in maternal and embryonic tissues during the first trimester. Mol Hum Reprod 2:239–243CrossRefPubMed
7.
go back to reference Kameda T, Matsuzaki N, Sawai K, Okada T, Saji F, Matsuda T, Hirano T, Kishimoto T, Tanizawa O (1990) Production of interleukin-6 by normal human trophoblast. Placenta 11:205–213CrossRefPubMed Kameda T, Matsuzaki N, Sawai K, Okada T, Saji F, Matsuda T, Hirano T, Kishimoto T, Tanizawa O (1990) Production of interleukin-6 by normal human trophoblast. Placenta 11:205–213CrossRefPubMed
8.
go back to reference Leylek OA, Tayaksi M, Ercelsan T, Dokmetas S (1999) Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. Gynecol Obstet Invest 47:229–234CrossRefPubMed Leylek OA, Tayaksi M, Ercelsan T, Dokmetas S (1999) Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. Gynecol Obstet Invest 47:229–234CrossRefPubMed
9.
go back to reference Masuhiro K, Matsuzaki N, Nishino E, Taniguchi T, Kameda T, Li Y, Saji F, Tanizawa O (1991) Trophoblast-derived interleukin-1 (IL-1) stimulates the release of human chorionic gonadotropin by activating IL-6 and IL-6-receptor system in the first trimester human trophoblasts. J Clin Endocrinol Metab 72:594–601CrossRefPubMed Masuhiro K, Matsuzaki N, Nishino E, Taniguchi T, Kameda T, Li Y, Saji F, Tanizawa O (1991) Trophoblast-derived interleukin-1 (IL-1) stimulates the release of human chorionic gonadotropin by activating IL-6 and IL-6-receptor system in the first trimester human trophoblasts. J Clin Endocrinol Metab 72:594–601CrossRefPubMed
10.
go back to reference Matsuzaki N, Neki R, Sawai K, Shimoya K, Okada T, Sakata M, Saji F, Koishihara Y, Ida N (1995) Soluble interleukin-6 (IL-6) receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer. J Clin Endocrinol Metab 80:2912–2917PubMed Matsuzaki N, Neki R, Sawai K, Shimoya K, Okada T, Sakata M, Saji F, Koishihara Y, Ida N (1995) Soluble interleukin-6 (IL-6) receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer. J Clin Endocrinol Metab 80:2912–2917PubMed
11.
go back to reference Meisser A, Cameo P, Islami D, Campana A, Bischof P (1999) Effects of interleukin-6 (IL-6) on cytotrophoblastic cells. Mol Hum Reprod 5:1055–1058CrossRefPubMed Meisser A, Cameo P, Islami D, Campana A, Bischof P (1999) Effects of interleukin-6 (IL-6) on cytotrophoblastic cells. Mol Hum Reprod 5:1055–1058CrossRefPubMed
12.
go back to reference Nishino E, Matsuzaki N, Masuhiro K, Kameda T, Taniguchi T, Takagi T, Saji F, Tanizawa O (1990) Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotropin release through IL-6 receptor on human trophoblasts. J Clin Endocrinol Metab 71:436–441CrossRefPubMed Nishino E, Matsuzaki N, Masuhiro K, Kameda T, Taniguchi T, Takagi T, Saji F, Tanizawa O (1990) Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotropin release through IL-6 receptor on human trophoblasts. J Clin Endocrinol Metab 71:436–441CrossRefPubMed
13.
go back to reference Rodien P, Bremont C, Sanson M-LR et al (1998) Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N Engl J Med 339:1823–1826CrossRefPubMed Rodien P, Bremont C, Sanson M-LR et al (1998) Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N Engl J Med 339:1823–1826CrossRefPubMed
14.
go back to reference Safari HR, Fassett MJ, Souter IC, Alsulyman OM, Goodwin TM (1998) The efficacy of methylprednisolone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study. Am J Obstet Gynecol 179:921–924CrossRefPubMed Safari HR, Fassett MJ, Souter IC, Alsulyman OM, Goodwin TM (1998) The efficacy of methylprednisolone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study. Am J Obstet Gynecol 179:921–924CrossRefPubMed
15.
go back to reference Taylor R (1996) Successful management of hyperemesis gravidarum using steroid therapy. QJM 89:103–107CrossRefPubMed Taylor R (1996) Successful management of hyperemesis gravidarum using steroid therapy. QJM 89:103–107CrossRefPubMed
16.
go back to reference Yanushpolsky EH, Ozturk M, Polgar K, Berkowitz RS, Hill JA (1993) The effects of cytokines on human chorionic gonadotropin (hCG) production by a trophoblast cell line. J Reprod Immunol 25:235–247CrossRefPubMed Yanushpolsky EH, Ozturk M, Polgar K, Berkowitz RS, Hill JA (1993) The effects of cytokines on human chorionic gonadotropin (hCG) production by a trophoblast cell line. J Reprod Immunol 25:235–247CrossRefPubMed
Metadata
Title
Interleukin-6 levels in hyperemesis gravidarum
Authors
Naci K. Kuscu
Yasemin Yildirim
Faik Koyuncu
Ahmet Var
Bekir S. Uyanik
Publication date
01-11-2003
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 1/2003
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-002-0412-6

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