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01-08-2019 | Cytokines | Original Paper

Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing

Authors: Marcio Guidoni, Mariana Moreira Figueira, Gabrielly Pereira Ribeiro, Dominik Lenz, Pamela Aparecida Grizotto, Thiago de Melo Costa Pereira, Rodrigo Scherer, Stanislau Bogusz Jr., Marcio Fronza

Published in: Archives of Dermatological Research | Issue 6/2019

Abstract

This work aimed to evaluate the in vivo capacity of a vegetable oil blend formulation (VOB) developed to accelerate cutaneous wound closure. Total thickness wounds were punctured on the skin on the back side of each animal and topically treated with the VOB formulation, Dersani^® ointment or the vehicle control. After 2, 7, 14, 21 days post-wounding, five animals from each group were euthanized, and the rates of wound closure and re-epithelialization were evaluated. The wounds were harvested for histological and biochemical analysis. VOB resulted in faster and greater re-epithelialization in the in vivo excisional wounds, exhibiting significant wound area reduction of 8.9, 8.0, 35.1, 45.2 and 47.0% after 2, 5, 10, 14 and 21 days post-wounding, respectively, when compared with the vehicle control. Histological and biochemical analyses showed that the VOB-treated wounds exhibited a significant increase of granular tissue and controlled inflammatory response by modulation of the release of pro-inflammatory cytokines TNF-α, IL-6 and IL-1. Moreover, VOB-treated wounds showed a significant and concrete increase in the deposition and organisation of collagen fibres in the wound site and improved the quality of the scar tissue. Altogether, these data revealed that VOB accelerates wound healing processes and might be beneficial for treating wound disorders.

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Title: Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing
Authors: Marcio Guidoni
Mariana Moreira Figueira
Gabrielly Pereira Ribeiro
Dominik Lenz
Pamela Aparecida Grizotto
Thiago de Melo Costa Pereira
Rodrigo Scherer
Stanislau Bogusz Jr.
Marcio Fronza
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keyword: Cytokines
Published in: Archives of Dermatological Research / Issue 6/2019
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-019-01919-8

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Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing

Abstract

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