Published in:
01-09-2010 | Original Paper
GABA and GABAA receptor expression on immune cells in psoriasis: a pathophysiological role
Authors:
Rishi Nigam, Husameldin El-Nour, Beni Amatya, Klas Nordlind
Published in:
Archives of Dermatological Research
|
Issue 7/2010
Login to get access
Abstract
Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABAA receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy control skin, using an immunohistochemistry technique. Pruritus was determined using a visual analog scale. Inflammatory cells immunoreactive for the GABA ligand and the GABAA R were increased (P < 0.01, respectively) in the involved skin. Cells stained for GABA ligand were mostly macrophages with some lymphocytes, while cells stained for GABAA R were macrophages, neutrophils or lymphocytes. There was a positive correlation when comparing GABA ligand (P = 0.05) and GABAA R (P < 0.05) expressing inflammatory cells, with pruritus. The GABA ligand and its GABAA R may play a role for the pathogenesis of psoriasis as well as for pruritus in this disease.