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01-02-2009 | Letter to the Editor

Innate and acquired immunity in psoriasis

Authors: Larisa Prpić-Massari, Marija Kaštelan

Published in: Archives of Dermatological Research | Issue 2/2009

Excerpt

Recently, we read the manuscript by Langewouters et al. [3] on prevailing lymphocyte subsets in the peripheral blood of patients with moderate-to-severe (PASI-score ≥ 12) versus mild (PASI-score < 12) plaque psoriasis. The authors found a significant upregulation of CD4+, CD8+, CD45RO+ and CD45RA+ lymphocyte subsets as well as CD94+ and CD161+ NK-T cells. In the conclusion, the authors highlight the importance of further research in order to elucidate the dynamics of compartmentalization of T lymphocyte subsets belonging to either the acquired or the innate immunity system in psoriasis [3]. …

Clark R, Kupper T (2005) Old meets new: the interaction between innate and adaptive immunity. J Invest Dermatol 125:629–637. doi:10.1111/j.0022-202X.2005.23856.x PubMedCrossRef

Kaštelan M, Prpić Massari L, Gruber F et al (2004) Perforin expression is up-regulated in the epidermis of psoriatic lesions. Br J Dermatol 151:831–836. doi:10.1111/j.1365-2133.2004.06168.x PubMedCrossRef

Langewouters AMG, Van Erp PEJ, De Jong EMGJ, Van de Kerkhof PCM (2008) Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis. Arch Dermatol Res 300:107–113. doi:10.1007/s00403-007-0819-9 PubMedCrossRef

Prpić L, Strbo N, Sotosek V et al (2000) Assessment of perforin expression in peripheral blood lymphocytes in psoriatic patients during exacerbation of disease. Acta Derm Venereol Suppl (Stockh) 211:14–16

Prpić Massari L, Kaštelan M, Laškarin G et al (2007) Analysis of perforin expression in peripheral blood and lesions in severe and mild psoriasis. J Dermatol Sci 47:29–36. doi:10.1016/j.jdermsci.2007.02.007 PubMedCrossRef

Schlaak JF, Buslau M, Jochum W et al (1994) T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 102:145–149. doi:10.1111/1523-1747.ep12371752 PubMedCrossRef

Title: Innate and acquired immunity in psoriasis
Authors: Larisa Prpić-Massari
Marija Kaštelan
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 2/2009
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-008-0925-3

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