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Open Access 01-10-2008 | Review

Is there a role for mast cells in psoriasis?

Authors: Ilkka T. Harvima, Gunnar Nilsson, Mireille-Maria Suttle, Anita Naukkarinen

Published in: Archives of Dermatological Research | Issue 9/2008

Abstract

Mast cells have traditionally been considered as effector cells in allergy but during the last decade it has been realized that mast cells are essentially involved in the mechanisms of innate and acquired immunity. Upon activation by anaphylactic, piecemeal degranulation or degranulation-independent mechanisms mast cells can secrete rapidly or slowly a number of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express cell surface co-stimulatory receptors and ligands, and they can express MHC class II molecules and thereby present antigens. These soluble factors and cell surface molecules can interact with other cells, such as endothelial cells, keratinocytes, sensory nerves, neutrophils, T cell subsets and antigen presenting cells which are essential effectors in the development of skin inflammation. Besides promoting inflammation, mast cells may attempt in some circumstances to suppress the inflammation and epidermal growth but the regulation between suppressive and proinflammatory mechanisms is unclear. Psoriasis is characterized by epidermal hyperplasia and chronic inflammation where tryptase- and chymase-positive MC_TC mast cells are activated early in the developing lesion and later the cells increase in number in the upper dermis with concomitant expression of cytokines and TNF superfamily ligands as well as increased contacts with neuropeptide-containing sensory nerves. Due to the intimate involvement of mast cells in immunity and chronic inflammation the role of mast cells in psoriasis is discussed in this review.

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Title: Is there a role for mast cells in psoriasis?
Authors: Ilkka T. Harvima
Gunnar Nilsson
Mireille-Maria Suttle
Anita Naukkarinen
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 9/2008
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-008-0874-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is there a role for mast cells in psoriasis?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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