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Archives of Orthopaedic and Trauma Surgery

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01-11-2013 | Arthroscopy and Sports Medicine

Weak link of tendon–bone healing and a control experiment to promote healing

Authors: Wenliang Zhai, Chenwei Lv, Yanmei Zheng, Yuechuan Gao, Zhenqi Ding, Zhiwen Chen

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 11/2013

Abstract

Objective

This study aims to observe the mechanical weak point and histological features of tendon–bone interface after anterior cruciate ligament reconstructive surgery and to explore the tendon–bone healing effects of the platelet-rich gel (PRG) + deproteinized bone (DPB) compound.

Methods

A total of 48 New Zealand white rabbits were randomly divided into normal group, model (without embedding), experimental (embedded with the PRG + DPB compound), and control (embedded with DPB) groups. The rabbits were executed at 2, 4, 8, and 12 weeks after the operation. Then, micro-computed tomography scan and uniaxial tensile test were conducted. The fractured specimens were subjected to histological observation.

Results

At 4, 8, and 12 weeks after the operation, the bone density of the tendon–bone bound section of the experimental group was higher than that of the other groups (P < 0.05). At 4 and 8 weeks, the maximum tensile load of the experimental group was obviously higher than that of the control and model groups (P < 0.05). Histological observation indicated that the tendon–bone interface in the experimental group had more cartilage and bone tissue growing toward the internal tendon, but the fracture layer mainly occurred in the non-ankylosed part.

Conclusion

The mechanical weak point of the early tendon–bone interface was in the immature fibrous tissue. The PRG + DPB compound can effectively trigger tendon–bone healing by promoting the maturation and ossification of the tendon–bone tissue. This compound improved the tensile strength of the healing interface and reduced bone tunnel enlargement.

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Title: Weak link of tendon–bone healing and a control experiment to promote healing
Authors: Wenliang Zhai
Chenwei Lv
Yanmei Zheng
Yuechuan Gao
Zhenqi Ding
Zhiwen Chen
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 11/2013
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-013-1802-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Weak link of tendon–bone healing and a control experiment to promote healing

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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