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Archives of Orthopaedic and Trauma Surgery

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01-01-2011 | Orthopaedic Surgery

A new preclinical femoral head osteonecrosis model in sheep

Authors: Roberto Vélez, Francisco Soldado, Alberto Hernández, Ignasi Barber, Marius Aguirre

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 1/2011

Abstract

Introduction

Animal models have been used as insight into the pathogenesis of osteonecrosis, even though most have failed to reproduce all stages of human disease, limiting progression in experimental treatment modalities. A new surgically induced animal model of femoral head osteonecrosis in sheep is presented.

Method

Osteonecrosis was achieved using an improved method of intracephalic cryogenic lesion by means of a cryoprobe and vascular ligation.

Results

Histologic findings at 6 and 12 weeks showed progression to advanced stage osteonecrosis. MRI, the gold standard in diagnosis and follow-up in human osteonecrosis showed concordant results with histology.

Conclusion

Our model can therefore be used as a preclinical femoral head osteonecrosis model in an easily accessible animal to assess biological treatments with MRI.

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Title: A new preclinical femoral head osteonecrosis model in sheep
Authors: Roberto Vélez
Francisco Soldado
Alberto Hernández
Ignasi Barber
Marius Aguirre
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 1/2011
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-010-1084-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A new preclinical femoral head osteonecrosis model in sheep

Abstract

Introduction

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Method

Results

Conclusion

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