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Archives of Orthopaedic and Trauma Surgery

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01-02-2005 | Original Article

Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee

Authors: Anders Björkman, Isabella M. Burtscher, Peter J. Svensson, Andreas Hillarp, Jack Besjakov, Göran Benoni

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 1/2005

Abstract

Introduction

The pathogenesis behind osteonecrosis of the knee is still unknown. Circulatory impairment of the bone secondary to thrombosis in the microcirculation has been suggested as a mechanism. The purpose of this study was to examine the association between osteonecrosis of the knee and abnormalities in the thrombotic pathway in the form of factor V Leiden and the prothrombin 20210A gene mutation.

Materials and methods

Thirty-eight consecutive patients (13 men and 25 women) with osteonecrosis of the knee without a history of knee trauma or surgery to the knee were enrolled in this study. Assays for the detection of factor V Leiden and the prothrombin 20210A gene mutation were performed, and the results were compared with those from 282 healthy volunteers.

Results

Six patients were diagnosed with secondary osteonecrosis, four corticosteroid-induced and two alcohol-induced. In 32 patients, no aetiological factor was found, and these patients were diagnosed with primary osteonecrosis of the knee. Twelve patients had 14 gene mutations, 11 factor V Leiden and 3 prothrombin 20210A gene mutations. Factor V Leiden and the prothrombin 20210A gene mutation occurred significantly (p=0.006) more frequently in patients with osteonecrosis than in a population of 282 healthy volunteers (odds ratio 3.1, 95%CI 1.4–6.6).

Conclusion

The results of this study suggest that coagulation abnormalities in the form of factor V Leiden and the prothrombin 20210A gene mutation might play a role in osteonecrosis of the knee.

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Title: Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee
Authors: Anders Björkman
Isabella M. Burtscher
Peter J. Svensson
Andreas Hillarp
Jack Besjakov
Göran Benoni
Publication date: 01-02-2005
Publisher: Springer-Verlag
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 1/2005
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-004-0760-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee

Abstract

Introduction

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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